ROLE OF POLYMORPHISM OF GENES OF THE ANTIOXIDANT SYSTEM ENZYMES IN THE HABITUAL MISCARRIAGE GENESIS
Abstract
The article is dedicated to the habitual miscarriage as to one of most actual problems of modern obstetrics and gynecology. In spite of multiple, formerly known reasons of such pathology, a lot of factors, predisposing to reproductive losses, still have not been studied. In last decades scientists have been focused on the studies of the role of genetic factors in the habitual miscarriage genesis. The genetically determined insufficiency of the antioxidant system can seriously undermine the organism homeostasis. It is interesting to study the influence of carriage of polymorphic variants of genes of the antioxidant system enzymes, as of a factor, negatively impacting the course of pregnancy
About the Authors
K. V. Morozova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
post-graduate student of the department of obstetrics and gynecology
Russian Federation
post-graduate student of the department of obstetrics and gynecology
N. N. Lutsenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Ph.D., assistant professor of obstetrics and gynecology
Russian Federation
Ph.D., assistant professor of obstetrics and gynecology
References
1. Aul'chenko Yu.S., Aksenovich T.P. Vestnik VOGiS. 2006; 10 (1): 189-202.
2. Baranov B.C., Ailamazyan E.K. Zhurnal akusherstva i zhenskikh boleznei. 2007. LVI (1): 3-10.
3. Baranov B.C., Baranova E.V., Ivashchenko T.E. The human genome as a scientific basis for predictive medicine. In .: Genomics medicine. Ed. VI Ivanov and LL Kiselyov [Genom cheloveka kak nauchnaya osnova prediktivnoi meditsiny. V kn.: Genomika meditsine. Red. V.I. Ivanova i L.L. Kiseleva]. Moscow . 2005; 392 s.
4. Baranov V.S., Baranova E.V., Ivashchenko T.E., Aseev M.V. Human Genome and «susceptibility genes». Introduction to predictive medicine [Genom cheloveka i «geny predraspolozhennosti». Vvedenie v prediktivnuyu meditsinu]. St. Petersburg. 2000; 272 s.
5. Bespalova O.N. Zhurnal akusherstva i zhenskikh boleznei. 2007; LVI (1): 81-95.
6. Sterile marriage. Current approaches to diagnosis and treatment. Ed. IV Kulakov [Besplodnyi brak. Sovremennye podkhody k diagnostike i lecheniyu. Pod red. I.V. Kul akova]. Moscow. 2005; 616 s.
7. Bochkov N.P. Clinical genetics. Textbook. 3rd ed., Rev. and ext. [Klinicheskaya genetika. Uchebnik. 3-e izd., ispr. i dop.] Moscow. 2004; 480 s.
8. Bochkov N.P. Klinicheskaya genetika. Uchebnik. 3-e izd. M. 2004. 480 s.
9. Del’vig A.A., Robinson D.S., Semenov B.F. The cellular and molecular b asis of antigen presentation [Kletochnye i molekulyarnye osnovy prezentatsii antigenov]. Moscow. 2004;184 s.
10. Dobrokhotova Yu.E., Ozerova R.I., Mandrykina Zh.A., Rora L.S. The role of chromosomal aberrations in the development of complications I trimester of gestation. Proceedings of the 9th All-Russia Scientific Forum «Mother and Child» [Rol’ khromosomnykh aberratsii v razvitii oslozhnenii I trimestra gestatsii. Materialy 9-go vserossiiskogo nauchnogo foruma «Mat’ i Ditya»]. Moscow. 2007; 67-68.
11. Zolotukhin P.V. Valeologiya. 2010; 2: 2218- 2268.
12. Kravchenko L.V. Toksikologicheskii vestnik. 2005; 1: 14-20.
13. Kulakov V.I., Serov V.N., Sharapova O.V., Kira E.F. Akusherstvo i ginekologiya. 2005.
14. 1 4. Mel’nikov S.V., Evstaf’eva A.G., Vartapetyan A.G. Molekulyarnaya biologiya. 2007; 41 (5):868-875.
15. Nazarenko S.A., Yakovleva Yu.S. Human cytogenetics and chromosomal diseases. [Tsitogenetika cheloveka i khromosomnye bolezni]. Tomsk. 2001; 83 s.
16. Nesyaeva E.V. Akusherstvo i ginekologiya. 2005; 2: 3-7.
17. Senchuk A.Ya., Ventskovskii B.M., Mel’nichuk V.D. i soavt. Praktikuyushchii vrach. 2004; 3: 35.
18. Serov V.N., Tikhomirov A.L., Lubnin D.M. Modern principles of treatment of inflammatory diseases of the female genital organs. Metodicheskoe guide for obstetriciangynecologists [Sovremennye printsipy terapii vospalitel’nykh zabolevanii zhenskikh polovykh organov. Metodicheskoe posobie dlya vrachei akusherov-ginekologov]. Moscow. 2003; 19 s.
19. Sibiryak C.B., Chereshnev V.A., Simbirtsev A.C., Sibiryak D.S., Gavrilova T.V. Cytokine regulation of biotransformation of xenobiotics and endogenous compounds [Tsitokinovaya regulyatsiya biotransformatsii ksenobiotikov i endogennykh soedinenii]. Ekaterinburg. 2006; 160 s.
20. Sidel’nikova V.M, Sukhikh G.T. Miscarriage [Nevynashivanie beremennosti]. Moscow. 2010; 536 s.
21. Sidel’nikova V.M. Podgotovka i vedenie beremennosti u zhenshchin s privychnym nevynashivaniem. Metodicheskie posobiya i klinicheskie protokoly [Preparation and maintenance of pregnancy in women with recurrent pregnancy loss. Methodological tools and clinical protocols]. Moscow. 2010; 219 s.
22. Skvortsova M.Yu., Podzolkova N.M. Ginekologiya. 2010; 12 (1): 12.
23. Sukhikh G.T., Safronova V.G., Van’ko L.V. Byul. eksper. biol. med. 2002; 134 (8): 124-135.
24. Khandogina E.K., Rozhkova Z.N., Khandogina A.V. Fundamentals of Medical Genetics. Textbook [Osnovy meditsinskoi genetiki. Uchebnoe posobie]. Moscow. 2004; 176 s.
25. Khodzhaeva D.A., Lunina S.N., Lutsenko H.H. Vestnik RGMU. 2011; 2: 134-136.
26. Chesnokova N.P., Ponukalina E.V., Bizenkova M.N. Sovremennye naukoemkie tekhnologii. 2006; 6: 28-34.
27. Association between single nucleotide polymorphisms of 5’-untranslated region of GPx4 gene and male infertility. Liu S.Y., Zhang C.J., Si X.M., Yao Y.F., Shi L., Ke J.K., Yu L., Shi L., Yang Z.Q., Huang X.Q., Su n H., Chu J.Y. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Jun; 28 (3): 270-4. Chinese.
28. Bermano G., Pagmantidis V., Holloway N., Kadri S., Mowat N.A., Shiel R.S., Arthur J.R., Mathers J.C., Daly A.K., Broom J., Hesketh J.E. Evidence that a polymorphism within the 3’UTR of glutathione peroxidase 4 is functional and is a ssociated with susceptibility to colorectal cancer. School of Life Sciences, The Robert Gordon University, Aberdeen, AB25 1HG, UK . Genes Nutr. 2007 Nov; 2 (2): 225-32.
29. Cindrova-Davies T., Hong-Wa Y. et al Oxidative stress, gene expression and protein changes induced in the human placenta during labor. Am. J. Pathol. 2007; 171 (4): 1117-1168.
30. J Matern Fetal Neonatal Med. 2012 Mar 21. Rosta K., Molvarec A., Enzsöly A., Nagy B., Rónai Z., Fekete A., Sasvári-Székely M., Rigó J. Jr., Vér A. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. Eur J Obstet Gynecol Reprod Biol. 2009 Feb; 142 (2): 134-8. Epub 20 08. Dec 23.
31. Lin J.C., Kuo W.R., Chiang F.Y., Hsiao P.J., Lee K.W., Wu C.W., Juo S.H. Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer. Surgery. 2009 May; 145 (5): 508-13. Epub 2009 Feb 23.
32. Luigetti M., Lattante S., Zollino M., Conte A., Marangi G., Del G rande A., Sabatelli M. SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variant. Neurobiol Aging. 2011 Oct; 32 (10): 1924.e15 -8. Epub 2011 May 28.
33. Mlakar S.J., Osredkar J., Prezelj J., Marc J. Antioxidant enzymes GSR, SOD1, SOD2, and CAT gene variants and bone mineral density values in postmenopausal women: a genetic association analysis. Menopause. 2012 Mar; 19 (3): 368-76.
34. M ohammedi K., Maimaitiming S., Emery N., Bellili-Muñoz N., Roussel R., Fumeron F., Hadjadj S., Marre M., Velho G. Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects. Mol Genet Metab. 2011 Dec; 104 (4): 654-60. Epub 2011 Sep 8.
35. Quick S.K., Shields P.G., Nie J., Platek M.E. , McCann S.E., Hutson A.D., Trevisan M., Vito D., Modali R., Lehman T.A., Seddon M., Edge S.B., Marian C., Muti P., Freudenheim J.L.Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk.Ca ncer Epidemiol Biomarkers Prev. 2008 May; 17 (5): 1082-7.
36. Ramprasath T., Murugan P.S., Kalaiarasan E., Gomathi P., Rathinavel A., Selvam G.S., Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H: Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes. Mol Cell Biochem. 2012 Feb; 361 (1-2): 143.
37. Seamus J. Murphy, Anne E. Hughes, Chr is C. Patterson, Lesley A. Anderson, R.G. Peter Watson, Brian T. Johnston, Harry Comber, Jim McGuigan John, V. Reynoldsand, Liam J. Murray. A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett’s esophagus and esophageal adenocarcinoma. Carcinogenesis. 2007; 28 (6): 1323-1328.
38.
39.
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For citations:
Morozova K.V., Lutsenko N.N. ROLE OF POLYMORPHISM OF GENES OF THE ANTIOXIDANT SYSTEM ENZYMES IN THE HABITUAL MISCARRIAGE GENESIS. Obstetrics, Gynecology and Reproduction. 2015;9(2):54-61. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.2.054-061
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