Catastrophic antiphospholipid syndrome. Pathogenesis issues
Abstract
Сatastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, variant of the antiphospholipid syndrome that results in a widespread coagulopathy and high titres os antiphospholipid antibodies and affects predominantly small vessels supplying organs with the development of multiorgan failure. International approaches on terminology, risk factors, pathogenesis, criteria of diagnostics, clinical symptoms and management of patients with CAPS are reviewed. Own clinical experience of management 17 patients with CAPS development also presented. CAPS is life-threatening condition but optimal treatment for CAPS is not developed yet. CAPS presents a multidisciplinary problem.
About the Authors
V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
MD., Professor, Department of Obstetrics and Gynecology
Russian Federation
MD., Professor, Department of Obstetrics and Gynecology
D. K. Khizroeva
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
PhD, Department of Obstetrics and Gynecology
Russian Federation
PhD, Department of Obstetrics and Gynecology
L. E. Idrisova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
PhD, researcher at the Department of of Obstetrics and Gynecology Department
Russian Federation
PhD, researcher at the Department of of Obstetrics and Gynecology Department
R. R. Abramyan
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
PhD, Department of Obstetrics and Gynecology
Russian Federation
PhD, Department of Obstetrics and Gynecology
M. D. Andreeva
Kuban State Medical University of the Russian Health Ministry, Krasnodar
Russian Federation
the Chair of Obstetrics, Gynecology and Perinatolology
Russian Federation
the Chair of Obstetrics, Gynecology and Perinatolology
A. D. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
MD, corresponding member of the Russian Academy of Sciences, Professor,
Russian Federation
MD, corresponding member of the Russian Academy of Sciences, Professor,
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For citation:
Bitsadze V.O., Khizroeva D.Kh., Idrisova L.E., Abramyan R.R., Andreeva M.D., Makatsariya A.D. Catastrophic antiphospholipid syndrome. Pathogenesis issues. Obstetrics, Gynecology and Reproduction. 2015;9(2):32-53. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.2.032-053
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