Insufficiency of luteal phase defect an assessment of criteria in patients with endocrine forms of infertility

Full Text:


An Insufficiency of the corpus luteum (LPI) is one of the main causes of endocrine forms of infertility and spontaneous loss of the fetus in early pregnancy. Insufficiency of the corpus luteum, and consequently, defective secretory transformation of the endometrium during the second phase of the menstrual cycle, is a direct consequence of violations of folliculogenesis. A comprehensive assessment of the reproductive system prior to initiating therapy allows to develop algorithm of examination of patients, to choose an individual, pathogenetically substantiated treatment strategy, to select the doses and to avoid the possibility of complications. The object of the study is a comprehensive comparative assessment of the reproductive system of patients with impaired function of the corpus luteum suffering from endocrine forms of infertility and optimization criteria for determining the NLF. Materials and Methods: the study involved 170 women, including the control group. During the study was assessed the state of physical, hormonal profile, as well as ultrasound picture of the state of the reproductive system. Results and Conclusion: LPI is a multifactorial condition. Considering the performance levels of progesterone and estradiol, three forms of insufficient of luteal phase were determined and depending on it, the patients received pathogenetically grounded therapy.

About the Author

A. G. Davudova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
PhD student Department of Obstetrics and Gynecology


1. Actual problems of miscarriage. Cycle clinical lectures. Ed. VM Sidelnikova [Aktual’nye problemy nevynashivaniya beremennosti. Tsikl klinicheskikh lektsii. Pod red. V.M. Sidel’nikovoi. Moscow. 2001; 170. (In Russian)].

2. Bitsadze V.O., Akin’shina S.V., Khizroeva D.Kh., Makatsariya N.A., Stuleva N.S., Mashkova T.M. Akusherstvo, ginekologiya i reproduktsiya/ Obstetrics, gynecology and reproduction. 2014; 2: 79-88.

3. Vorob'eva E.V. Evaluation of the reproductive system to optimize the treatment principles of endocrine forms of infertility in women of late reproductive age. PhD. Dis. [Otsenka sostoyaniya reproduktivnoi sistemy v optimizatsii printsipov lecheniya endokrinnykh form besplodiya u zhenshchin pozdnego reproduktivnogo vozrasta. Dis. …kand. med. nauk. (In Russian)] Moscow. 2012; 187.

4. Gynecology – national leadership. ed. V.I. Kulakov, G.M. Savelyev, I.B. Manukhina [Ginekologiya – natsional’noe rukovodstvo pod red. V.I. Kulakova, G.M. Savel’evoi, I.B. Manukhina. (In Russian)]. Moscow. 2009.

5. Kulakov V.I., Margiani F.A., Nazarenko T.A., Dubnitskaya L.V. Akusherstvo i ginekologiya. 2001; 3: 33-36.

6. Saidova R.A., Vorob’eva E.V., Monastyrnaya O.A. Ginekologiya. 2012; 14 (2): 69-74.

7. Saidova R.A., Makatsariya A.D. Selected lectures on gynecology [Izbrannye lektsii po ginekologii. (In Russian)]. Moscow. 2005; 117-118.

8. Saidova R.A., Fedina E.V., Makatsariya A.D., Bykovskaya O.S. The basic principles of hormonal correction of menstrual dysfunction in patients of reproductive age with recurrent MQM [Osnovnye printsipy gormonal’noi korrektsii narushenii menstrual’noi funktsii u bol’nykh reproduktivnogo perioda s retsidiviruyushchimi DMK. (In Russian)]. Moscow. 2008; 14-22.

9. Smetnik V.P., Tumilovich L.G. Non-immediate gynecology [Neoperativnaya ginekologiya. (In Russian)]. Moscow. 1997; 436-441.

10. Tatarchuk T.F., Bulavenko O.V., Tutchenko T.M. Zdorov’ya lanki. 2008; 2: 90-96.

11. Balasch J., Vanrell J.A. Luteal phase deficiency: An inadequate endometrial response to normal hormone stimulation. Int J Fertil. 1986; 31: 368.

12. Beer A.E., Kwak J. Reproductive medicine program Finch University of Health Science: Chicago Medical Scool. 1999; 132.

13. Bonney R.C., Franks S. Baillier Clin Endocrinol Med. 1990; 4 (2): 207-231.

14. G. E. Seegar Jones. Some newer aspects of the management of infertility. JAMA. 1949;141(16):1123-1129.

15. Fluker M., Fisher S. Anovulation and ovulatory dysfunction. In: Falcone T, Hurd WW. Clinical reproductive medicine and surgery. New York. 2007; 277-86.

16. Lessey B.A., Castelbaum A.J. Integrins and implantation in the human. Rev Endocr Metab Disord. May 2002; 3 (2): 107-17.

17. Miller P., Soules M. Luteal Phase Deficiency: pathophysiology, diagnosis, and treatment. Glob. libr. women’s med. 2009; 1756-2228.

18. Siklósi G.S., Bánhidy F.G., Ács N. Fundamental role of folliculo-luteal function in recurrent miscarriage. Arch Gynecol Obstet. Nov 2012; 286 (5): 1299-305.

19. Sonntag B., Ludwig M. An integrated view on the luteal phase: diagnosis and treatment in subfertility. Clin Endocrinol (Oxf). Oct 2012; 77 (4): 500-7.

20. Soules M.R. Luteal phase deficiency. In Pitkin RM (eds): Clinical Obstetrics and Gynecology. Philadelphia. 1991; 34-123.

21. Yen S.C., Jaffe R.B., Barbieri R.L. Luteal phase defects. In: Reproductive Endocrinology. 4th ed. 1999: 244-5.




For citations:

Davudova A.G. Insufficiency of luteal phase defect an assessment of criteria in patients with endocrine forms of infertility. Obstetrics, Gynecology and Reproduction. 2015;9(2):24-30. (In Russ.)

Views: 657

ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)