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Preterm labour (PL) is one of the most important worldwide medical and social problems. PL is the main reason of perinatal mortality and morbidity. More than 50% of all PL are late PL (labour at 34(0) - 36(6) weeks). Perinatal mortality during late PL is minimal, but more than 25% of these children still are admitted to the intensive care unit. Modern view on the late PL problem and perinatal morbidity prophylaxis are provided in the review article.

About the Authors

P. V. Kozlov
The Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, Moscow
Russian Federation
MD, professor of obstetrics and gynecology

N. J. Ivannikov
Maternity hospital №1, Moscow
Russian Federation
Chief Physician branch №1

P. A. Kuznecov
The Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, Moscow
Russian Federation
MD, assistant professor of obstetrics and gynecology

I. I. Bogaeva
The Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, Moscow
Russian Federation
senior laboratory assistant


1. Antonov A.G., Arestova N.N., Baibarina E.N. i dr. Pod red. N.N. Volodina Neonatology. National leadership [Neonatologiya. Natsional’noe rukovodstvo]. Moscow. 2009.

2. Kozlov P.V. Premature rupture of membranes at preterm pregnancy. (Prediction. Clinical management. Perinatal outcomes). Dr. diss. [Prezhdevremennyi razryv okoloplodnykh obolochek pri nedonoshennoi beremennosti. (Prognozirovanie. Taktika vedeniya. Perinatal’nye iskhody). Avtoref. diss. …dokt. med. nauk]. Moscow. 2010.

3. Makarov O.V., Gankovskaya L.V., Kozlov P.V., Bakhareva I.V., Romanovskaya V.V., Kuznetsov P.A. Akusherstvo i ginekologiya. 2008; 5: 19-24.

4. Methodological letter from the Ministry of Health and Social Development, «Premature birth» [Metodicheskoe pis’mo ministerstva zdravookhraneniya i sotsial’nogo razvitiya «Prezhdevremennye rody»]. 2011.

5. ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists. Obstet. Gynecol. 2002; 99 (273): 871-873.

6. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol. 2007; 109 (4): 1007-1019.

7. Baron I.S., Erickson K., Ahronovich M.D., Baker R., Litman F.R. Cognitive deficit in preschoolers born late-preterm. Early Hum Dev. 2011 Feb; 87 (2): 115-9.

8. Baumert M., Agnieszka L., Krzych L.J., Jacek M., Małgorzata P. Late preterm infantscomplications during the early period of adaptation. Ginekol Pol. 2011 Feb; 82 (2): 119-25.

9. Carreno C.A., Costantine M.M., Holland M.G., Ramin S.M., Saade G.R., Blackwell S.C. Medically indicated late preterm births. Am J Obstet Gynecol. 2011 Mar; 204 (3): 263.

10. Carreno C.A., Refuerzo J.S., Holland M.G., Ramin S.M., Saade G.R., Blackwell S.C. The Frequency of Prior Antenatal Corticosteroid Therapy in Late Preterm Birth Pregnancies. Am J Perinatol. 2011 Jun 30.

11. Crump C., Winkleby M.A., Sundquist K., Sundquist J. Risk of diabetes among young adults born preterm in Sweden. Diabetes Care. 2011 May; 34 (5): 1109-13.

12. Cock M.L., Albuquerque C.A., Joyce B.J., Hooper S.B., Harding R. Effects of intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep. Am J Obstet Gynecol. 2001 Jan; 184 (2): 209-16.

13. Davidoff M.J., Dias T., Damus K. et al. Changes in the gestational age distribution among U.S. singleton births: impact on rates of late preterm birth, 1992-2002. Semin Perinatol. 2006; 30: 8-15.

14. Denney J.M., Culhane J.F., Goldenberg R.L. Prevention of preterm birth. Womens Health (Lond Engl). 2008 Nov; 4 (6): 625-38.

15. Engle W.A., Tomashek K.M., Wallman C. Committee on Fetus and Newborn, American Academy of Pediatrics. «Late-preterm» infants: a population at risk. Pediatrics. 2007 Dec; 120 (6):1390-1401.

16. Elimian A., Verma U., Beneck D., Cipriano R., Visintainer P., Tejani N. Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. Obstet. Gynecol. Sep. 2000; 96 (3): 333-336.

17. Executive summary for Born too Soon:The Global action report on preterm birth. WHO, PMNCH, March of Dimes, Save the Children, 2012.

18. Gázquez Serrano I.M., Arroyos Plana A., Díaz Morales O., Herráiz Perea C., Holgueras Bragado A. Antenatal corticosteroid therapy and late preterm infant morbidity and mortality. An Pediatr (Barc). 2014 Mar 1. pii: S1695-4033(14)00070-8.

19. Goldenberg R.L., Gravett M.G., Iams J., Papageorghiou A.T., Waller S.A., Kramer M., Culhane J., Barros F., Conde-Agudelo A., Bhutta Z.A., Knight H.E., Villar J. The preterm birth syndrome: issues to consider in creating a classification system. Am J Obstet ynecol. 2012 Feb; 206 (2): 113-8.

20. Gouyon J.B., Vintejoux A., Sagot P., Burguet A., Quantin C., Ferdynus C.; Burgundy Perinatal Network. Neonatal outcome associated with singleton birth at 34-41 weeks of gestation. Int J Epidemiol. 2010 Jun; 39 (3): 769-76.

21. Guideline on the use of Antenatal Corticosteroids to Prevent Respiratory Distress Syndrome.

22. Gyamfi-Bannerman C., Gilbert S., Landon M.B., Spong C.Y., Rouse D.J., Varner M.W., Meis P.J., Wapner R.J., Sorokin Y., Carpenter M., Peaceman A.M., O'Sullivan M.J., Sibai B.M., Thorp J.M., Ramin S.M., Mercer B.M. Eunice Kennedy Shriver National Institute of Child Health; Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Effect of antenatal corticosteroids on respiratory morbidity in singletons after latepreterm birth. Obstet Gynecol. 2012 Mar; 119 (3): 555-9.

23. Hansen A.K., Wisborg K., Uldbjerg N., Henriksen T.B. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ. 2008; 336: 85-7.

24. Hogue C.J., Parker C.B., Willinger M., Temple J.R., Bann C.M., Silver R.M., Dudley D.J., Koch M.A., Coustan D.R., Stoll B.J., Reddy U.M., Varner M.W., Saade G.R., Conway D., Goldenberg R.L. A population-based casecontrol study of stillbirth: the relationship of significant life events to the racial disparity for African Americans. Am J Epidemiol. 2013 Apr 15; 177 (8): 755-67.

25. Jaiswal A., Murki S., Gaddam P., Reddy A. Early Neonatal Morbidities in Late Preterm Infants. Indian Pediatr. 2010 Nov 30.

26. Kerem E., Dollberg S., Paz I. Prenatal ritodrine administration and the incidence of respiratory distress syndrome in premature infants. J. Perinatol. 1997; 17 (2): 101-106.

27. Khashu M., Narayanan M., Bhargava S., Osiovich H. Perinatal outcomes associated with preterm birth at 33 to 36 weeks' gestation: a population-based cohort study. Pediatrics. 2009 Jan; 123 (1): 109-13.

28. Liggins G.C. The prevention of RDS by Maternal Betamethazone Administration. In: Lung maturation and the prevention of hyaline membrane disease. Report of the 70th Ross Conference on Pediatric Research. Columbus, OH: Ross Laboratories. 1976; 97.

29. Liggins G.C., Howie R.N. A controlled trial of antepartum glucocorticoid treatment for prevention of RDS in premature infants. Pediatr. 1972; 50: 515-525.

30. Lubow J.M., How H.Y., Habli M., Maxwell R., Sibai B.M. Indications for delivery and shortterm neonatal outcomes in late preterm as compared with term births. Am J Obstet Gynecol. 2009 May; 200 (5): 30-33.

31. Ma X.L., Xu X.F., Chen C., Yan C.Y., Liu Y.M., Liu L., Xiong H., Sun H.Q., Lai J.P., Yi B., Shi J.Y., Du L.Z. National Collaborative Study Group for Neonatal Respiratory Distress in Late Preterm or Term Infants Epidemiology of respiratory distress and the illness severity in late preterm or term infants: a prospective multi-center study. Chin Med J (Engl). 2010 Oct; 123 (20): 2776-80.

32. Machado L.C. Júnior, Passini Júnior R., Rodrigues Machado Rosa I. Late prematurity: a systematic review. J Pediatr (Rio J). 2014 May-June; 90 (3): 221-231.

33. Mally P.V., Bailey S., Hendricks-Muñoz K.D. Clinical issues in the management of late preterm infants. Curr Probl Pediatr Adolesc Health Care. 2010 Oct; 40 (9): 218-33.

34. McDonald S.D., Han Z., Mulla S., Beyene J. Knowledge Synthesis Group. Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ. 2010 Jul 20; 341: 3428.

35. McDonald S.D., Han Z., Mulla S., Lutsiv O., Lee T., Beyene J. Knowledge Synthesis Group. High gestational weight gain and the risk of preterm birth and low birth weight: a systematic review and meta-analysis. J Obstet Gynaecol Can. 2011 Dec; 33 (12): 1223-33.

36. McGowan J.E., Alderdice F.A., Holmes V.A., Johnston L. Early childhood development of late-preterm infants: a systematic review. Pediatrics. 2011 Jun; 127 (6): 1111-24.

37. Meloni A., Antonelli A., Deiana S., Rocca A., Atzei A., Paoletti A.M., Melis G.B. Late preterm: obstetric management. J Matern Fetal Neonatal Med. 2010 Oct; 23 Suppl 3: 113-5.

38. Miller S.L., Chai M., Loose J., Castillo Melendez M., Walker D.W., Jenkin G., Wallace E.M. The effects of maternal betamethasone administration on the intrauterine growthrestricted fetus. Endocrinology 2007; 148: 1288-95.

39. Morken N.H., Källen K., Jacobsson B. Outcomes of preterm children according to type of delivery onset: a nationwide populationbased study. Paediatr Perinat Epidemiol. 2007; 21 (5): 458-464.

40. Moutquin J.M. Classification and heterogeneity of preterm birth. BJOG. 2003; 110: 30- 33.

41. Pattinson R.C., Makin J.D., Funk M. The use of dexamethasone in women with preterm premature rupture of membranes—a multicentre, double-blind, placebo-controlled, randomised trial. S. Afr. Med. J. Aug. 1999; 89 (8): 865-870.

42. Picone S., Aufieri R., Paolillo P. Infection in late preterm infants. Early Hum Dev. 2014 Mar; 90 (1): 71-4.

43. Picone S., Paolillo P. Neonatal outcomes in a population of late-preterm infants. J Matern Fetal Neonatal Med. 2010 Oct; 23.

44. Roberts D., Dalziel S.R. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews. 2006; Issue 3.

45. Royal College of Obstetricians and Gynaecologists (RCOG). Antenatal corticosteroids to reduce neonatal morbidity and mortality. London (UK): Royal College of Obstetricians and Gynaecologists (RCOG). 2010 Oct.; 13 p.

46. Sauerwald A., Rath W. Lung maturation therapy with glucocorticoids in threatened premature labor. Considerations of risk-benefit in evidence-based medicine. Z. Geburtsh. Neonatol. Nov.-Dec. 2000; 204 (6): 203-209.

47. Schaap A.H., Wolf H., Bruinse H.W. Smolders-De Haas H., Van Ertbruggen I., Treffers P.E. Effects of antenatal corticosteroid administration on mortality and long-term morbidity in early preterm, growth-restricted infants. Obstet Gynecol. 2001; 97: 954-60.

48. Sibai B.M. Preeclampsia as a cause of preterm and late preterm (near-term) births. Semin Perinatol. 2006; 30: 16-19.

49. Simchen M.J., Alkazaleh F. Adamson S.L., Windrim R., Telford J., Beyene J., Kingdom J. The fetal cardiovascular response to antenatal steroids in severe early-onset intrauterine growth restriction. Am J Obstet Gynecol 2004; 190: 296-304.

50. Stone P., Grant S., Sadler L. The use of ultrasound measurement of fetal lung length to predict neonatal respiratory outcome after prolonged premature rupture of the membranes. Fetal. Diagn. Ther. Mar.-Apr. 2005; 20 (2): 152-157.

51. Stutchfield P., Whitaker R., Russell I. Antenatal Steroids for Term Elective Caesarean Section (ASTECS) Research Team. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. BMJ. 2005; 331: 662.

52. Talge N.M., Holzman C., Wang J., Lucia V., Gardiner J., Breslau N. Late-preterm birth and its association with cognitive and socioemotional outcomes at 6 years of age. Pediatrics. 2010 Dec; 126 (6): 1124-31.

53. Tita A.T., Landon M.B., Spong C.Y., Lai Y., Leveno K.J., Varner M.W., Moawad A.H., Caritis S.N., Meis P.J., Wapner R.J., Sorokin Y., Miodovnik M., Carpenter M., Peaceman A.M., O’Sullivan M.J., Sibai B.M., Langer O., Thorp J.M., Ramin S.M., Mercer B.M. Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009 Jan 8; 360 (2): 111-20.

54. Varner M.W., Silver R.M., Rowland Hogue C.J., Willinger M., Parker C.B., Thorsten V.R., Goldenberg R.L. Association between stillbirth and illicit drug use and smoking during pregnancy. Obstet Gynecol. 2014 Jan; 123 (1): 113-25.

55. Villar J., Abalos E., Carroli G., Giordano D. Heterogeneity of perinatal outcomes in the preterm delivery syndrome. Obstet. Gynecol. Jul. 2004; 104 (1): 78-87.

56. Woythaler M.A., McCormick M.C., Smith V.C. Late preterm infants have worse 24-month neurodevelopmental outcomes than term infants. Pediatrics. 2011 Mar; 127 (3).

57. Zhang X.R., Zeng C.M., Liu J. Risk factors for preterm birth and complications in 287 late preterm infants. Zhongguo Dang Dai Er Ke Za Zhi. 2011 Mar; 13 (3): 177-80.



For citations:

Kozlov P.V., Ivannikov N.J., Kuznecov P.A., Bogaeva I.I. EPIDEMIOLOGY, ETIOLOGY AND PATHOGENESIS OF LATE PRETERM LABOUR. Obstetrics, Gynecology and Reproduction. 2015;9(1):68-76. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)