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Photodynamic therapy and cervical intraepithelial neoplasia: current achievements and development prospects


Nowadays, photodynamic therapy (PDT) is a high-technology actively developing treatment method used in clinical medicine. An interest in this method is primarily due to the fact that its destructive action is based on the mechanisms of free radical oxidation, altered tumor vascular stroma and immune cell-mediated elimination. Owing to current research, improving the quality of photosensitizers and light sources, it becomes possible to expand indications for using this method beyond oncological practice. Generalized data on PDT effectiveness and safety for the treatment of cervical lesions, as well as the ease to use, allow us to attribute this technique to some promising approaches.

About the Authors

A. I. Ishchenko
Sechenov University
Russian Federation

Anatoly I. Ishchenko – MD, Dr Sci Med, Professor, Head of the Department of Obstetrics and Gynecology № 1, Sklifosovsky Institute of Clinical Medicine

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

I. V. Reshetov
Sechenov University
Russian Federation

Igor V. Reshetov – MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Oncology and Reconstructive Surgery, Sklifosovsky Institute of Clinical Medicine

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

E. A. Sosnova
Sechenov University
Russian Federation

Elena A. Sosnova – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology № 1, Sklifosovsky Institute of Clinical Medicine

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

A. L. Unanyan
Sechenov University
Russian Federation

Ara L. Unanyan – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology № 1, Sklifosovsky Institute of Clinical Medicine

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4

A. A. Ishchenko
National Medical Research Center "Treatment and Rehabilitation Center", Health Ministry of Russian Federation
Russian Federation

Anton A. Ishchenko – MD, PhD, Head of the Center for Gynecology and New Reproductive Technologies

125367, Moscow, Ivankovskoe Нighway, 3

L. A. Klyukina
Sechenov University
Russian Federation

Lidiya A. Klyukina – MD, Postgraduate Student, Department of Obstetrics and Gynecology № 1, Sklifosovsky Institute of Clinical Medicine

119991, Moscow, Bolshaya Pirogovskaya Str., 2 bldg. 4


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For citations:

Ishchenko A.I., Reshetov I.V., Sosnova E.A., Unanyan A.L., Ishchenko A.A., Klyukina L.A. Photodynamic therapy and cervical intraepithelial neoplasia: current achievements and development prospects. Obstetrics, Gynecology and Reproduction. 2022;16(5):600-610. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)