Obstetrics, Gynecology and Reproduction

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In the world literature many works which main object of studying are women with repeated miscarriage and infertile women after IVF are published. Majority of these researches demonstrated significant association between the circulation of thyroid autoantibodies, infertility and high risk of fetal loss. Adequate level of thyroid hormones is necessity for normal functioning of reproductive system. In this article the association of miscarriage and autoimmune diseases of thyroid gland is considered. This association arose not incidentally perhaps the mechanism of such interrelation is that fact that existence of antibodies reflects the general activation of immune system and increases autoimmune process against feto-placental system. Objective: to investigate spectrum of antiphospholipid antibodies in patients with various forms of autoimmune thyroid disease and a history of recurrent pregnancy loss. Materials and Methods: 154 women were involved including 112 women with autoimmune thyroid disease (Graves' disease, autoimmune thyroiditis, postpartum thyroiditis) and 42 with miscarriage history, but without thyroid disease. Results: there is no significant difference between the frequency of detection of antiphospholipid syndrome (APS) among women with ATD and without ATD and with anamnesis of miscarriage. However, APS most often detected in patients with thyrotoxicosis (45%; p <0.005). High incidence of APS among women with autoimmune thyroiditis (33.33%) also identified. Conclusion: check up of thyroid status for all pregnant women with increased thyroid function could be recommended. Early detection and correction of the hemostatic system and thyroid dysfunction during pregnancy will help to prevent complications.

About the Authors

S. A. Alieva
Dagestan State Medical Academy
Russian Federation
Assistant of the Department of Obstetrics and Gynecology

M. A. Odamanova
Dagestan State Medical Academy
Russian Federation
MD, PhD, Department of Obstetrics and Gynecology

S. Z. Allakhkulieva
Dagestan State Medical Academy
Russian Federation
MD, assistant professor of obstetrics and gynecology

T. Kh. Khashaeva
Dagestan State Medical Academy
Russian Federation
Professor, Head of the Department of Obstetrics and Gynecology


1. Aleks F. Muler i Ari Bergkhaut. Autoimmune thyroiditis and pregnancy [Autoimmunnyi tireoidit i beremennost']. Thyroid International. 2004; 3.

2. Bitsadze V.O., Khizroeva D.Kh., Makatsariya N.A., Egorova E.S., Baimuradova S.M., Mashkova T.Ya. Akusherstvo, ginekologiya i reproduktsiya. 2014; 8 (2): 39-60.

3. Gusova Z.R., Sizyakina L.P. Allergologiya i immunologiya. 2002; 3 (2): 305-308.

4. Mel'nichenko G.A. Thyroid disease and pregnancy. Proc.: Diseases of the endocrine system (management of internal medicine). Ed. II Dedov [Bolezni shchitovidnoi zhelezy i beremennost'. V kn.: Bolezni organov endokrinnoi sistemy (rukovodstvo po vnutrennim boleznyam). Pod red. I.I. Dedova]. Moscow. 2002.

5. Selkhadzhieva M.S. Akusherstvo, ginekologiya i reproduktsiya. 2014; 8 (1): 31-33.

6. Fadeev V.V., Mel'nichenko G.A. Problemy endokrinologii. 2001; 47 (4): 7-13.

7. Fadeev V.V. Thyroid disease in the lung region of iodine deficiency [Zabolevaniya shchitovidnoi zhelezy v regione legkogo iodnogo defitsita]. Moscow. 2005.

8. Davis L.E., Lucas M.J., Hankins G.D., Roark M.L., Cunningham F.G. Thyrotoxicosis complicating pregnancy. Am J Obstet Gynecol. 1989; 160 (1): 63-70.

9. Hamza N., Khochtali I., Gassab E., Baba A. Graves' disease associated with cerebrovascular disease and antiphospholipid antibody syndrome. Int J Endocrinol. 2010; Sep 2.

10. Jain A. Antiphospholipid antibody syndrome associated with Graves' disease presenting as inferior vena cava thrombosis with bilateral lower limb DVT. Clin. Med. Insights Case Reports. 2014 April 16; 7: 37-9.

11. Jones W.R. Autoimmune disease and pregnancy. Aust N Z J Obstet Gynaecol. 1994 Jun; 34 (3): 251-8.

12. Kutteh W.H., Yetman D.L., Carr A.C., Beck L.A., Scott R.T., Jr. Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction. Fertil Steril. 1999; 71 (5): 843-848.

13. Morita H., Arima T., Matsuda M. Prevalence of nonthyroid specific autoantibodies in autoimmune thyroid diseases. J Clin Endocrinol Metab. 1995; 80: 1203-1206.

14. Paggi A., Caccavo D., Ferri G.M. et al. Anti-cardiolipin antibodies in autoimmune thyroid diseases. Clin Endocrinol. 1994; 40: 329-333.




For citations:

Alieva S.A., Odamanova M.A., Allakhkulieva S.Z., Khashaeva T.K. THE VALUE OF ANTIPHOSPHOLIPID ANTIBODIES CIRCULATION IN WOMEN WITH AUTOIMMUNE DISEASES OF THYROID GLAND AND MISCARRIAGE IN HISTORY. Obstetrics, Gynecology and Reproduction. 2015;9(1):13-18. (In Russ.)

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