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Metalloproteinases as biochemical markers of pregnancy pathology


The success in modern biology has significantly enriched scientific understanding of the pathogenetic basis underlying some diseases, including obstetric and gynecological practice. Despite this, the etiology and pathogenesis of some conditions are not yet fully elucidated. One of the approaches is to study metalloproteinases during pregnancy, particularly concerning occurrence of formidable complication such as preeclampsia, which diagnostics and significance have been continuously revised. Preeclampsia is a disease that leads altered course of pregnancy, and sometimes even to maternal and/or fetal death. Currently, no specific treatment for preeclampsia has been proposed, but early prognosis is crucial for a more favorable maternal and fetal outcome. Given that metalloproteinase activity is able to influence trophoblast invasion and remodeling of spiral arteries, insights into such processes are of high importance. 

About the Authors

K. N. Grigorieva
Sechenov University
Russian Federation

MD, Medical Resident, Department of Obstetrics and Gynecology, 

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

V. O. Bitsadze
Sechenov University
Russian Federation

MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

J. Kh. Khizroeva
Sechenov University
Russian Federation

MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

M. V. Tretyakova
Sechenov University
Russian Federation

MD, PhD, Obstetrician-Gynecologist, Assistant, Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinical Hospital, GC «Mother and Child»
Russian Federation

MD, PhD, MBA, Head of Medical and Scientific Affairs, 4–10 Sadovaya-Triumfalnaya Str., Moscow 127006;

Neurologist, 111, 1st Uspenskoe Highway, Lapino, Odintsovo District, Moscow region 143081

N. A. Makatsariya
Sechenov University
Russian Federation

MD, PhD, Associate Professor, Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

V. I. Tsibizova
Institute of Perinatology and Pediatrics; Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology;

Physician, Department of Functional and Ultrasound Diagnostics, 2 Akkuratova Str., Saint Petersburg 197341

I. A. Nakaidze
Sechenov University
Russian Federation

MD, Postgraduate Student, Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

N. R. Gashimova
Sechenov University
Russian Federation

MD, Postgraduate Student, Department of Obstetrics and Gynecology, 

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

E. Grandone
Sechenov University; Research Center «Casa Sollievo della Sofferenza»

MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991;

Head of the Department of Thrombosis and Hemostasis, 1 Viale Cappuccini, San Giovanni Rotondo 71013

A. D. Makatsariya
Sechenov University
Russian Federation

MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology,

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991


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For citations:

Grigorieva K.N., Bitsadze V.O., Khizroeva J.K., Tretyakova M.V., Blinov D.V., Makatsariya N.A., Tsibizova V.I., Nakaidze I.A., Gashimova N.R., Grandone E., Makatsariya A.D. Metalloproteinases as biochemical markers of pregnancy pathology. Obstetrics, Gynecology and Reproduction. 2022;16(1):38-47. (In Russ.)

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