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The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.240

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Abstract

Aim: to find out the predictive value of blood serum biochemical parameters PAPP-A (pregnancy-associated plasma protein A) and β-hCG (beta subunit of human chorionic gonadotropin) in the assessment of unfavorable pregnancy outcomes in women infected by human immunodeficiency virus (HIV) as well as viral hepatitis B (HBV) and C (HCV).

Materials and Methods. A retrospective study of the medical records from 52 women was carried out, including 19 HIV-infected women, 9 women with monoinfection HBV or HCV, 11 pregnant women who were co-infected (HIV/HBV or HIV/HCV) and 13 uninfected women. PAPP-A and β-hCG levels, expressed as MoM (multiple of median), were evaluated in all women.

Results. Our study revealed that only PAPP-A was prognostically significant for developing chronic placental insufficiency in women with HIV infection and co-infection of HIV together hepatitis B and C. None of the parameters examined were significant in women with HBV or HCV monoinfection. PAPP-A and β-hCG in pregnant women without infections were effective in predicting development of chronic placental insufficiency.

Conclusion. PAPP-A can be used as a diagnostic parameter of developing chronic placental insufficiency in pregnant women with monoinfection HIV and co-infection with HIV/HBV or HIV/HCV.

About the Authors

S. Yu. Pseush
Kuban State University
Russian Federation

Saida Yu. Pseush – Bachelor, Faculty of Biology, Department of Genetics, Microbiology and Biochemistry

149 Stavropolskaya Str., Krasnodar 350040



L. V. Zozulya
Kuban State University
Russian Federation

Lada V. Zozulya – MD, PhD (Biology), Associate Professor, Department of Genetics, Microbiology and Biochemistry

149 Stavropolskaya Str., Krasnodar 350040



L. L. Mikhaleva
Perinatal Center «Children's Regional Clinical Hospital», Ministry of Health of Krasnodar Region
Russian Federation

Lada L. Mikhaleva – MD, Biologist, Clinical Diagnostic Laboratory

1 Pobedy Square, Krasnodar 350007



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For citation:


Pseush S.Yu., Zozulya L.V., Mikhaleva L.L. The predictive value indicators of first trimester biochemical screening in assessing unfavorable factors of pregnancy course in women with HIV as well as hepatitis B and C. Obstetrics, Gynecology and Reproduction. 2021;15(6):686-694. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.240

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)