Беременность в пожилом возрасте матерей и отцов
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.231
Аннотация
Среди женщин, отложивших беременность до более старшего возраста, наблюдается более высокая частота бесплодия, хромосомных аберраций, неудач экстракорпорального оплодотворения, внематочной беременности, самопроизвольных абортов, преэклампсии, предлежания плаценты, гестационного сахарного диабета, операций кесарева сечения, хронических заболеваний с более высокой частотой госпитализации в отделения интенсивной терапии и более высокой частотой материнской смертности. В основном это связано с социально-экономическими причинами, а также с ростом использования противозачаточных средств. Проблемы из-за преклонного возраста матери возникают и с донорством яйцеклеток: с возрастом донора связаны хромосомные аберрации. Возраст отца также играет важную роль в исходе беременности. Впрочем, имеющиеся в доступной литературе мнения различаются. Следует рекомендовать консультирование семейных пар.
Об авторе
К. ДадакАвстрия
Дадак Кристиан – доктор медицинских наук, профессор кафедры акушерства и гинекологии, отделение общей гинекологии и гинекологической онкологии.
Вена.
Scopus Author ID: 7003466206.
Список литературы
1. Statistik Austria, 2015. Available at: http://statistik.at/web_de/statistiken/index.html.
2. Fretts R.C. Management of pregnancy in women of advanced age. UpToDate, 2017. Available at: https://www.uptodate.com/contents/management-of-pregnancy-in-women-of-advanced-age.
3. Rille-Pfeiffer Ch. Osterreichisches Institut fur Familienforschung. Univ Wien: pers Mitteilung, 2017.
4. Assisted Reproductive Technology. National Summary Report. Centers for Disease Control and Prevention, 2014. 78 p. Available at: https://www.cdc.gov/art/pdf/2014-report/art-2014-national-summary-report.pdf.
5. Yeh J.S., Steward R.G., Dude A.M. et al. Pregnancy rates in donor oocytes cycles compared to similar autologous in vitro fertilization cycles: an analyses of 26,457 fresh cycles from the Society for Assisted Reproductive Technology. Fertil Steril. 2014;102(2):399-404. https://doi.org/10.1016/j.fertnstert.2014.04.027.
6. Balasch J., Gratacos E. Delayed childbearing: effects on fertility and the outcome of pregnancy. Curr Opin Obstet Gyn. 2012;24(3):187-93. https://doi.org/10.1097/GCO.0b013e3283517908.
7. Schreinemachers D.M., Cross P.K., Hook E.B. Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births. Hum Genet. 1982;61(4):318-24. https://doi.org/10.1007/BF00276595.
8. NIPT/Cell Free DNA Screening. Available at: http://perinatalquality.org/2016.
9. Yogev Y., Melamed N., Bardin R. et al. Pregnancy outcome at extremely advanced maternal age. Am J Obstet Gynecol. 2010;203(6):558e.1-7. https://doi.org/10.1016/j.ajog.2010.07.039.
10. Paulson R.J., Boostanfar R., Saadat P. et al. Pregnancy in the sixth decade of life: obstetric outcomes in women of advanced reproductive age. JAMA. 2002;288(18):2320-3. https://doi.org/10.1001/jama.288.18.2320.
11. Gilbert W.M., Nesbitt T.S., Danielsen B. Childbearing beyond age 40: pregnancy outcome in 24,032 cases. Obstet Gynecol. 1999;93(1):9-14. https://doi.org/10.1016/s0029-7844(98)00382-2.
12. Jacobsson B., Ladfors L., Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol. 2004;104(4):727-33. https://doi.org/10.1097/01.AOG.0000140682.63746.be.
13. Haslinger C., Stoiber B., Capanna F. et al. Postponed pregnancies and risks of very advanced maternal age. Swiss Med Wkly. 2016;146:w14330. https://doi.org/10.4414/smw.2016.14330.
14. Fitzpatrick K.E., Tuffnell D., Kurinczuk J.J., Knight M. Pregnancy at very advanced maternal age: a UK population-based cohort study. BJOG. 2017;124(7):1097-106. https://doi.org/10.1111/1471-0528.14269.
15. Richards M.K., Flanagan M.R., Littman A.J. et al. Primary cesarean section and adverse delivery outcomes among women of very advanced maternal age. J Perinatol. 2016;36(4):272-7. https://doi.org/10.1038/jp.2015.204.
16. Reddy U.M., Ko C.W., Willinger M. Maternal age and the risk of stillbirth throughout pregnancy in the United States. Am J Obstet Gynecol. 2006;195:764-70. https://doi.org/10.1016/j.ajog.2006.06.019.
17. Berg C.J., Callaghan W.M., Syverson C., Henderson Z. Pregnancy-related mortality in the United States, 1998 to 2005. Obstet Gynecol. 2010;116(6):1302-9. https://doi.org/10.1097/AOG.0b013e3181fdfb11.
18. Crosnoe L.E., Kim E.D. Impact of age on male fertility. Curr Opin Obstet Gynecol. 2013;25(3):181-5. https://doi.org/10.1097/GCO.0b013e32836024cb.
19. Ford W.C., North K., Taylor H. et al. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod. 2000;15(8):1703-8. https://doi.org/10.1093/humrep/15.8.1703.
20. Ramasamy R., Chiba K., Butler P., Lamb D.J. Male biological clock: a critical analysis of advanced paternal age. Fertil Steril. 2015;103(6):1402-6. https://doi.org/10.1016/j.fertnstert.2015.03.011.
21. Hatch M., Kline J., Levin B. et al. Paternal age and trisomy among spontaneous abortions. Hum Genet. 1990;85(3):355-61. https://doi.org/10.1007/BF00206761.
22. Mathieu C., Ecochard R., Bied V. et al. Cumulative conception rate following intrauterine artificial insemination with husband's spermatozoa: influence of husband's age. Hum Reprod. 1995;10(5):1090-7. https://doi.org/10.1093/oxfordjournals.humrep.a136100.
23. Slama R., Werwatz A., Boutou O. et al. Does male age affect the risk pf spontaneous abortion? An approach using semiparametric regression. Am J Epidemiol. 2003;157(9):815-24. https://doi.org/10.1093/aje/kwg056.
24. Olshan A.F., Ananth C.V., Savitz D.A. Intrauterine growth retardation as an endpoint in mutation epidemiology: an evaluation based on paternal age. Mutat Res. 1995; 344(1-2):89-94. https://doi.org/10.1016/0165-1218(95)90043-8.
25. Shah P.S. Knowledge Synthesis Group on determinants of preterm/low birthweight births. Paternal factors and low birth weight, preterm, and small for gestational age births: a systematic review. Am J Obstet Gynecol. 2010; 202(2):103-23. https://doi.org/10.1016/j.ajog.2009.08.026.
26. Chen X.K., Wen S.W., Krewski D. et al. Paternal age and adverse birth outcomes: teenager or 40+, who is at risk? Hum Reprod. 2008; 23(6):1290-6. https://doi.org/10.1093/humrep/dem403.
27. Saha S., Barnett A.G., Foldi C. et al. Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood. PLoS Med. 2009;6(3):e40. https://doi.org/10.1371/journal.pmed.1000040.
28. Myrskyla M., Silventoinen K., Tynelius P., Rasmussen F. Is later better or worse? Association of advanced parental age with offspring cognitive ability among half a million young Swedish men. Am J Epidemiol. 2013;177(7):649-55. https://doi.org/10.1093/aje/kws237.
29. Reichenberg A., Gross R., Weiser M. et al. Advancing paternal age and autism. Arch Gen Psychiatry. 2006;63(9):1026-32. https://doi.org/10.1001/archpsyc.63.9.1026.
Рецензия
Для цитирования:
Дадак К. Беременность в пожилом возрасте матерей и отцов. Акушерство, Гинекология и Репродукция. 2021;15(4):415-418. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.231
For citation:
Dadak C. Pregnancy in advanced age of mothers and fathers. Obstetrics, Gynecology and Reproduction. 2021;15(4):415-418. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.231

Контент доступен под лицензией Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.