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Neonatal thrombosis: risk factors and principles of prophylaxis

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.233

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Abstract

Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration. We discuss the epidemiology of neonatal thrombosis and the main features of the hemostasis system in newborns, the most significant risk factors, including genetic and acquired thrombophilia. We consider the von Willebrand factor activity and ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) level in the development of neonatal thrombotic microangiopathy. Finally, we discuss the basic principles of prevented neonatal thrombosis by using low molecular weight heparins.

About the Authors

A. V. Vorobev
Sechenov University
Russian Federation

Alexander V. Vorobev - MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Researcher ID: F-8804-2017.

Scopus Author ID: 57191966265.



V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze - MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Scopus Author ID: 6506003478.

Researcher ID: F-8409-2017.



J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Scopus Author ID: 57194547147.

Researcher ID: F-8384-2017.



S. A. Potapkina
Sechenov University
Russian Federation

Sophia A. Potapkina - Student, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.



N. A. Makatsariya
Sechenov University
Russian Federation

Nataliya A. Makatsariya - MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991.

Researcher ID: F-8406-2017.



G. Rizzo
Sechenov University; University of Rome Tor Vergata
Russian Federation

Giuseppe Rizzo - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University; Professor, Director, Division of Maternal and Fetal Medicine, Ospedale Cristo Re, University of Rome Tor Vergata.

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; Rome.

Scopus Author ID: 7102724281.

Researcher ID: G-8234-2018.



G. C. Di Renzo
Sechenov University; Center for Prenatal and Reproductive Medicine, University of Perugia
Russian Federation

Gian C. Di Renzo - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health, Sechenov University; Director of the Center for Prenatal and Reproductive Medicine, University of Perugia; Honorary Secretary General of the International Federation of Gynecology and Obstetrics (FIGO).

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991; Umbria, Perugia, Piazza Italia.

Scopus Author ID: 7103191096.

Researcher ID: P-3819-2017.



D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical Group
Russian Federation

Dmitry V. Blinov - MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute for Preventive and Social Medicine; Neurologist, Lapino Clinical Hospital, MD Medical Group.

4—10 Sadovaya-Triumfalnaya Str., Moscow 127006; 1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081.

Scopus Author ID: 6701744871.

Researcher ID: E-8906-2017. RSCI: 9779-8290.



L. L. Pankratyeva
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian Federation
Russian Federation

Liudmila L. Pankratyeva - MD, Dr Sci Med, Head of the Clinical Research Center, Vorokhobov City Clinical Hospital № 67; Neonatologist, Hematologist, Associate Professor, Professor of the Department of Pediatrics and Health Organization, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.

2/44 Salyama Adilya Str., Moscow 123423; 1 Samora Machel Str., Moscow 117997.

Scopus Author ID: 7006391091.

Author ID: 697284.



V. I. Tsibizova
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Valentina I. Tsibizova - MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics; Physician, Department of Functional and Ultrasound Diagnostics, Almazov National Medical Research Centre.

2 Akkuratova Str., Saint Petersburg 197341.



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For citation:


Vorobev A.V., Bitsadze V.O., Khizroeva J.K., Potapkina S.A., Makatsariya N.A., Rizzo G., Di Renzo G.C., Blinov D.V., Pankratyeva L.L., Tsibizova V.I. Neonatal thrombosis: risk factors and principles of prophylaxis. Obstetrics, Gynecology and Reproduction. 2021;15(4):390-403. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.233

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