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Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins

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Our knowledge regarding chemical structure and properties of heparin and its derivatives, including biological properties in blood plasma, on the cell surface and while interacting with receptors, has been progressively growing. New insights are followed by the expansion of therapeutic opportunities and indications for the use of heparins. There are prerequisites for the creation of new generation drugs with modified properties that reduce a bleeding risk while applied for a non-anticoagulant goal. The non-anticoagulant heparin properties allow to consider it as a candidate for pathogenetic treatment of patients with COVID-19. This review focuses on the anticoagulant and non-anticoagulant heparin properties as well as the underlying molecular mechanisms.

About the Authors

V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, Filatov Institute of Children’s Health

Scopus Author ID: 6506003478; Researcher ID: F-8409-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

E. V. Slukhanchuk
Petrovsky National Research Centre of Surgery
Russian Federation

Ekaterina V. Slukhanchuk – MD, PhD, Head of the Department of Gynecology

2 Abrikosovskiy Lane, Moscow 119991

J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

Scopus Author ID: 57194547147; Researcher ID: F-8384-2017

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

M. V. Tretyakova
«Medical Center» LLC
Russian Federation

Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Department of Gynecology

15/1 Timura Frunze Str., Moscow 119021

N. V. Pyatigorskaya
Sechenov University
Russian Federation

Natalia V. Pyatigorskaya – MD, Dr Sci Pharm, Professor, Head of the Department of Industrial Pharmacy

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

S. V. Akinshina
Sechenov University
Russian Federation

Svetlana V. Akinshina – MD, PhD, Researcher, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

N. A. Makatsariya
Sechenov University
Russian Federation

Nataliya A. Makatsariya – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

K. E. Gotsiridze
Chachava Clinic

Ketevan E. Gotsiridze – MD, Obstetrician-Gynecologist, Head of the Center for Reproductive Health

38 Merab Kostava Str., Tbilisi 0179

N. N. Babaeva
«Altamed+» LLC
Russian Federation

Nigar N. Babaeva – MD, Obstetrician Obstetrician-Gynecologist

32B Soyuznaya Str., Odintsovo, Moscow Region 143006

K. N. Grigoreva
Sechenov University
Russian Federation

Kristina N. Grigoreva – MD, Medical Resident, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

A. S. Shkoda
Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department
Russian Federation

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya Str., Moscow 123423

I. Elalamy
Sechenov University; Medicine Sorbonne University; Hospital Tenon

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital Tenon

Scopus Author ID: 7003652413; Researcher ID: AAC-9695-2019

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

12 Rue de l’École de Médecine, 75006 Paris

4 Rue de la Chine, 75020 Paris

J.-C. Gris
Sechenov University; University of Montpellier

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health, Sechenov University; University of Montpellier

Researcher ID: AAA-2923-2019

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

163 Rue Auguste Broussonnet, Montpellier, Paris 34090

S. Shulman
McMaster University; Hamilton General Hospital; Karolinska Institute

Sam Shulman – MD, Dr Sci Med, Professor, Department of Hematology and Thromboembolism, Faculty of Medicine, McMaster University; Director, Clinical Thromboembolism Program, Hamilton General Hospital; Professor, Karolinska Institutet

1280 Main Street West, Hamilton, Ontario L8S 4K1

40 Wellington Street North, Hamilton, Ontario L8R 1M8

1 Solnavägen, Stockholm, 17177, Sweden


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For citation:

Bitsadze V.O., Slukhanchuk E.V., Khizroeva J.K., Tretyakova M.V., Pyatigorskaya N.V., Akinshina S.V., Makatsariya N.A., Gotsiridze K.E., Babaeva N.N., Grigoreva K.N., Shkoda A.S., Elalamy I., Gris J., Shulman S. Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins. Obstetrics, Gynecology and Reproduction. 2021;15(3):295-312. (In Russ.)

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