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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2021.183</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-966</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Opportunities for early diagnostics of contemporary obstetric sepsis</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности ранней диагностики современного акушерского сепсиса</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7807-4929</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беженарь</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Bezhenar</surname><given-names>V. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Беженарь Виталий Федорович – доктор медицинских наук, профессор, зав. кафедрой акушерства, гинекологии и репродуктологии </p><p>Researcher ID: R-7055-2017.</p><p>197022 Санкт-Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Vitaly F. Bezhenar – MD, Dr Sci Med, Professor, Head of the Department of Obstetrics, Gynecology and Reproductology</p><p>6–8 Lev Tolstoy Str., Saint Petersburg 197022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8516-3527</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапкайц</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapkaitz</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шапкайц Владимир Александрович – доктор медицинских наук, профессор кафедры акушерства, гинекологии и репродуктологии ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской Федерации, Санкт-Петербург, Россия; главный врач СПб ГБУЗ «Родильный дом № 16»</p><p>197022 Санкт-Петербург, ул. Льва Толстого, д. 6–8; 192283 Санкт-Петербург, ул. Малая Балканская, д. 54</p></bio><bio xml:lang="en"><p>Vladimir A. Shapkaitz – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Reproductology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia; Chief Physician, Saint Petersburg Maternity Hospital № 16</p><p>6–8 Lev Tolstoy Str., Saint Petersburg 197022; 54 Malaya Balkanskaya Str., Saint Petersburg 192283</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9819-213X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добровольская</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrovolskaya</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Добровольская Ирина Алексеевна – кандидат медицинских наук, доцент кафедры акушерства, гинекологии и репродуктологии </p><p>197022 Санкт-Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Irina A. Dobrovolskaya – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Reproductology</p><p>6–8 Lev Tolstoy Str., Saint Petersburg 197022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5634-8303</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рукояткина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rukoyatkina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рукояткина Елена Алексеевна – кандидат медицинских наук, зам. главного врача по медицинской части </p><p>192283 Санкт-Петербург, ул. Малая Балканская, д. 54</p></bio><bio xml:lang="en"><p>Elena A. Rukoyatkina – MD, PhD, Deputy Chief Physician</p><p>54 Malaya Balkanskaya Str., Saint Petersburg 192283</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7558-7657</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нестеров</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesterov</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нестеров Игорь Михайлович – кандидат медицинских наук, доцент кафедры акушерства, гинекологии и репродуктологии </p><p>197022 Санкт-Петербург, ул. Льва Толстого, д. 6–8;</p></bio><bio xml:lang="en"><p>Igor M. Nesterov – MD, PhD, Associate Professor, Department of Obstetrics, Gynecology and Reproductology</p><p>6–8 Lev Tolstoy Str., Saint Petersburg 197022</p></bio><email xlink:type="simple">ignester@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской Федерации; &#13;
СПб ГБУЗ «Родильный дом № 16»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University, Health Ministry of Russian Federation; &#13;
Saint Petersburg Maternity Hospital № 16</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>СПб ГБУЗ «Родильный дом № 16»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Maternity Hospital № 16</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>05</month><year>2021</year></pub-date><volume>15</volume><issue>2</issue><fpage>121</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bezhenar V.F., Shapkaitz V.A., Dobrovolskaya I.A., Rukoyatkina E.A., Nesterov I.M., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Беженарь В.Ф., Шапкайц В.А., Добровольская И.А., Рукояткина Е.А., Нестеров И.М.</copyright-holder><copyright-holder xml:lang="en">Bezhenar V.F., Shapkaitz V.A., Dobrovolskaya I.A., Rukoyatkina E.A., Nesterov I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/966">https://www.gynecology.su/jour/article/view/966</self-uri><abstract><sec><title>Aim</title><p>Aim: to objectively assess potential for early generalized postpartum infection diagnostics prior to the onset of irreversible organ changes based on a retrospective analysis.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. Сlinical and laboratory forensic medical data were examined by analysing 29 cases of severe maternal outcomes coupled to sepsis: including 17 «near miss» and 12 deceased patients (maternal mortality). The control group consisted of 30 patients who had chorioamnionitis in labor and successfully completed pregnancy. Statistical data analysis was carried out by using nonparametric statistics by creating conjugacy tables and assessing a relationship between parameters with Pearson χ2 distribution.</p></sec><sec><title>Results</title><p>Results. There were found significant differences in rate of some symptoms in both groups. Patients with severe maternal outcomes vs. control group were significantly more likely to develop hyperthermia ≥ 38.0 °C or hypothermia ≤ 36.0 °C, hectic fever, leukocytosis ≥ 12×109/L or leukopenia ≤ 4×109/L before the end of pregnancy; after pregnancy, persistent subfebrility, febrility or hypothermia, hectic fever, multiple-organ failure syndrome (PON), as well as uterine subinvolution and abnormal discharge from the genital tract were observed.</p></sec><sec><title>Conclusion</title><p>Conclusion. Early identification of recognized symptoms of systemic inflammatory response syndrome and PON allows to properly assess severity of patient condition, taking into account the risk of generalized infection, contributes to making correct diagnosis and timely implementation of adequate organizational and therapeutic measures.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель исследования</title><p>Цель исследования: объективная оценка возможностей ранней диагностики генерализованной послеродовой инфекции до наступления необратимых органных изменений.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Произведен ретроспективный анализ клинико-лабораторных данных по материалам судебно-медицинских экспертиз 29 случаев тяжелых материнских исходов, наступивших в результате сепсиса, в том числе у 17 «едва не умерших» («near miss») и у 12 умерших пациенток (maternal mortality). Контрольную группу составили 30 пациенток, перенесших хориоамнионит в родах и благополучно завершивших беременность. Статистический анализ результатов проведен методами непараметрической статистики с построением таблиц сопряженности с оценкой связи между признаками посредством распределения χ2 Пирсона. </p></sec><sec><title>Результаты</title><p>Результаты. Получены достоверные различия частоты выявления некоторых симптомов в обеих группах. У пациенток с тяжелыми материнскими исходами значимо чаще, чем в контрольной группе еще до окончания беременности развивались гипертермия ≥38,0 °С или гипотермия ≤36,0 °С, гектическая лихорадка, лейкоцитоз ≥12×109/л или лейкопения ≤4×109/л; после окончания беременности наблюдались стойкий субфебрилитет, фебрилитет или гипотермия, гектическая лихорадка, синдром полиорганной недостаточности (ПОН), а также субинволюция матки и патологические выделения из половых путей.</p></sec><sec><title>Заключение</title><p>Заключение. Раннее выявление известных симптомов синдрома системного воспалительного ответа и синдрома ПОН позволяет адекватно оценить степень тяжести состояния пациентки с учетом риска генерализации инфекции, способствует правильной постановке диагноза и своевременному проведению адекватных организационно-лечебных мероприятий.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>предикторы сепсиса</kwd><kwd>near miss</kwd><kwd>материнская смертность</kwd><kwd>хориоамнионит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>predictors of sepsis</kwd><kwd>near miss</kwd><kwd>maternal mortality</kwd><kwd>chorioamnionitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Акушерство: национальное руководство. Под ред. Г.М. Савельевой, Г.Т. Сухих, В.Н. Серова, В.Е. Радзинского. 2-е изд., перераб. и доп. 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