akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2020.176akusherstvo-873Research ArticleORIGINAL ARTICLEОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕQuality of life assessment in perimenopausal women with abnormal uterine bleeding and endometrial hyperplasiaОценка качества жизни женщин с гиперплазией эндометрия и аномальными маточными кровотечениями в перименопаузеhttps://orcid.org/0000-0003-0145-1420АбдыеваФ. В.AbdiyevaF. V.

Абдыева Фарида Вилаяткызы – докторант кафедры акушерства и гинекологии II

АZ 1078 Баку, ул. Братьев Мардановых, 100

Farida V. Abdiyeva – Doctoral Candidate, Department of Obstetrics and Gynecology II

100 Bratyev Mardanovykh Str., Baku AZ 1078

mic_amu@mail.ruАзербайджанский медицинский университетАзербайджанAzerbaijan Medical UniversityAzerbaijan202009012021146630636Copyright © Abdiyeva F.V., 20212021Абдыева Ф.В.Abdiyeva F.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/873

Aim: to assess the effects of several symptoms on the quality of life (QoL) in perimenopausal women with endometrial hyperplasia and abnormal uterine bleeding (АUB). Materials and Methods. This study was conducted from September, 2019 to June, 2020. In total, 50 women aged 45–55 years who visited gynecological department with complaints of AUB were randomly interviewed by using relevant questionnaire. MENQOL (Menopause-Specific Quality of Life Questionnaire) was used to assess and evaluate perimenopause related symptoms. Menopausal status was classified according to the definition of menopause proposed by the World Health Organization. Results. The majority (the total of 97.14 %) of women experienced at least five or more menopausal symptoms. Vasomotor symptoms were recorded as hot flushes (80 %), sweating (70 %), and night sweating (62 %). The most common physical symptoms were frequent back pain in the lumbar region (96 %), decreased physical strength (92 %), generalized weakness, tiredness (90 %), weight gain (80 %), and pain in the neck (90 %). Among participants, there were reported various problems such as depressive feeling of unknown reasons (20 %), anxiety and nervousness (20 %), dissatisfaction with personal life (44 %), poor memory (14 %), low mood (14 %), as well as impatience and irritability (12 %). Sexual problems were reported as changed sexual drive (20 %), vaginal dryness (10 %), and few avoided intimate contacts with the partners (10 %). Menopausal status, educational level and body mass indexes as well as marital status were also studied as those among the multi-factors significantly associated with the frequency and severity of menopause related symptoms. Conclusion. The severity of perimenopausal symptoms decreases the QoL in everyday life of women aged 45–55 years with endometrial hyperplasia and АUB.

Цель исследования: оценить влияние на качество жизни ряда симптомов у женщин в перименопаузе с гиперплазией эндометрия и аномальными маточными кровотечениями (АМК). Материал и методы. Исследование проводилось с сентября 2019 г. по июнь 2020 г. Всего опрошено 50 женщин в возрасте 45–55 лет, обратившихся в гинекологическое отделение с жалобами на АМК. Для оценки симптомов, связанных с перимено-паузой, использовали опросник качества жизни в менопаузе (англ. Menopause-Specific Quality of Life Questionnaire, MENQOL). Статус менопаузы классифицировался в соответствии с определением менопаузы ВОЗ. Результаты. Большинство (97,14 %) женщин испытывали 5 или более симптомов, характерных для менопаузы. Вазомоторные симптомы проявлялись в виде приливов (80 %), потливости (70 %) и ночного потоотделения (62 %). Наиболее частыми соматическими симптомами были частые боли в пояснице (96 %), снижение физической выносливости (92 %), общая слабость, усталость (90 %), увеличение массы тела (80 %), боль в шее (90 %). Обследованные указывали на беспричинное чувство депрессии (20 %), беспокойство и нервозность (20 %), неудовлетворенность личной жизнью (44 %), плохую память (14 %), плохое самочувствие (14 %), нетерпеливость и раздражительность (12 %). Сообщалось о сексуальных проблемах в виде изменения полового влечения (20 %), сухости влагалища (10 %) и некоторых случаев (10 %) нежелания интимного контакта с партнерами. Установлено, что особенности менопаузы, уровень образования и индекс массы тела, семейное положение, которые также изучались, в значительной степени связаны с частотой и выраженностью менопаузальных симптомов. Заключение. Тяжесть перименопаузальных симптомов снижает качество повседневной жизни женщин 45–55 лет с гиперплазией эндометрия и АМК

перименопаузакачество жизнисвязанные с перименопаузой симптомыгиперплазия эндометрияperimenopausequality of lifeperimenopausal related symptomsendometrial hyperplasiaReferencesNisar N., Sohoo N.A. Severity of menopausal symptoms and the quality of life at different status of menopause: a community based survey from rural Sindh, Pakistan. Int J Collaborative Res Intern Med Public Health. 2010;2(5):118–30.Nisar N., Sohoo N.A. Severity of menopausal symptoms and the quality of life at different status of menopause: a community based survey from rural Sindh, Pakistan. Int J Collaborative Res Intern Med Public Health. 2010;2(5):118–30.Avis N.E., Ory M., Matthews K.A. et al. Health-related quality of life in a multiethnic sample of middle-aged women: Study of Women's Health Across the Nation (SWAN). Med Care. 2003;41(11):1262–76. https://doi.org/10.1097/01.MLR.0000093479.39115.AF.Avis N.E., Ory M., Matthews K.A. et al. Health-related quality of life in a multiethnic sample of middle-aged women: Study of Women's Health Across the Nation (SWAN). Med Care. 2003;41(11):1262–76. https://doi.org/10.1097/01.MLR.0000093479.39115.AF.Berecki-Gisolf J., Begum N., Dobson A.J. Symptoms reported by women in midlife: Menopausal transition or aging? Menopause. 2009;16(5):1021–9. https://doi.org/10.1097/gme.0b013e3181a8c49f.Berecki-Gisolf J., Begum N., Dobson A.J. Symptoms reported by women in midlife: Menopausal transition or aging? Menopause. 2009;16(5):1021–9. https://doi.org/10.1097/gme.0b013e3181a8c49f.Chedraui P., San Miguel G., Avila C. Quality of life impairment during female menopausal transition is related to personal and partner factors. Gynecol Endocrinol. 2009;25(2):130–5. https://doi.org/10.1080/09513590802617770.Chedraui P., San Miguel G., Avila C. Quality of life impairment during female menopausal transition is related to personal and partner factors. Gynecol Endocrinol. 2009;25(2):130–5. https://doi.org/10.1080/09513590802617770.Funmilola M.O., Taiwo O. Experience of menopausal symptoms by women in an urban community in Ibadan, Nigeria. Menopause. 2009;16(4):822–30. https://doi.org/10.1097/gme.0b013e318198d6e7.Funmilola M.O., Taiwo O. Experience of menopausal symptoms by women in an urban community in Ibadan, Nigeria. Menopause. 2009;16(4):822–30. https://doi.org/10.1097/gme.0b013e318198d6e7.Loutfy I., Abdel Aziz F., Dabbous N. Women’s perception and experience of menopause: a community-based study in Alexandria, Egypt. East Mediterr Health J. 2006;12(2):93–106. https://apps.who.int/iris/handle/10665/117198.Loutfy I., Abdel Aziz F., Dabbous N. Women’s perception and experience of menopause: a community-based study in Alexandria, Egypt. East Mediterr Health J. 2006;12(2):93–106. https://apps.who.int/iris/handle/10665/117198.Peeyananjarassri K., Cheewadhanaraks S., Hubbard M. et al. Menopausal symptoms in a hospital-based sample of women in southern Thailand. Climacteric. 2006;9(1):23–9. https://doi.org/10.1080/13697130500487422.Peeyananjarassri K., Cheewadhanaraks S., Hubbard M. et al. Menopausal symptoms in a hospital-based sample of women in southern Thailand. Climacteric. 2006;9(1):23–9. https://doi.org/10.1080/13697130500487422.Robin G., Baffet H., Catteau-Jonard S. et al. Perimenopause or menopausal transition. Endocrinol Gynecol Obstet. 2012;21:243–56.Robin G., Baffet H., Catteau-Jonard S. et al. Perimenopause or menopausal transition. Endocrinol Gynecol Obstet. 2012;21:243–56.Avis N.E., Colvin A., Bromberger J.T. et al. Change in health-related quality of life over the menopausal transition in a multiethnic cohort of middle-aged women: Study of Women's Health Across the Nation. Menopause. 2009;16(5):860–9. https://doi.org/10.1097/gme.0b013e3181a3cdaf.Avis N.E., Colvin A., Bromberger J.T. et al. Change in health-related quality of life over the menopausal transition in a multiethnic cohort of middle-aged women: Study of Women's Health Across the Nation. Menopause. 2009;16(5):860–9. https://doi.org/10.1097/gme.0b013e3181a3cdaf.Munro M.G., Critchley H.O., Broder M.S., Fraser I.S., FIGO Working Group on Menstrual Disorders. FIGO classification system (PALMCOEIN) for causes of abnormal uterine bleeding in non gravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3–13. https://doi.org/10.1016/j.ijgo.2010.11.011.Munro M.G., Critchley H.O., Broder M.S., Fraser I.S., FIGO Working Group on Menstrual Disorders. FIGO classification system (PALMCOEIN) for causes of abnormal uterine bleeding in non gravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3–13. https://doi.org/10.1016/j.ijgo.2010.11.011.Saraswathi D., Thanka J., Shalinee R. et al. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynecol India. 2011;61(4):426–30. https://doi.org/10.1007/s13224-011-0047-2.Saraswathi D., Thanka J., Shalinee R. et al. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynecol India. 2011;61(4):426–30. https://doi.org/10.1007/s13224-011-0047-2.Dravta J., Real F., Schindler C. et al. Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 2009;16(2):385–94. https://doi.org/10.1097/gme.0b013e31818aefef.Dravta J., Real F., Schindler C. et al. Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 2009;16(2):385–94. https://doi.org/10.1097/gme.0b013e31818aefef.Vehid S., Aran S., Koksal S. et al. The prevalence and the age at the onset of menopause in Turkish women in rural area. Saudi Med J. 2006;27(9):1381–6.Vehid S., Aran S., Koksal S. et al. The prevalence and the age at the onset of menopause in Turkish women in rural area. Saudi Med J. 2006;27(9):1381–6.Norozi E., Mostafavi F., Hasanzadeh A. et al. Factors affecting quality of life in postmenopausal women, Isfahan, 2011. J Educ Health Promot. 2013;2:58. https://doi.org/10.4103/2277-9531.120857.Norozi E., Mostafavi F., Hasanzadeh A. et al. Factors affecting quality of life in postmenopausal women, Isfahan, 2011. J Educ Health Promot. 2013;2:58. https://doi.org/10.4103/2277-9531.120857.Poomalar G.K., Arounassalame B. The quality of life during and after menopause among rural women. J Clin Diagn Res. 2013;7(1):135–9. https://doi.org/10.7860/JCDR/2012/4910.2688.Poomalar G.K., Arounassalame B. The quality of life during and after menopause among rural women. J Clin Diagn Res. 2013;7(1):135–9. https://doi.org/10.7860/JCDR/2012/4910.2688.Lewis J.E., Hilditch J.R., Wong C.J. Further psychometric property development of the menopause-specific quality of life questionnaire and development of a modified version, MENQOL-Intervention questionnaire. Maturitas. 2005;50(3):209–21. https://doi.org/10.1016/j.maturitas.2004.06.015.Lewis J.E., Hilditch J.R., Wong C.J. Further psychometric property development of the menopause-specific quality of life questionnaire and development of a modified version, MENQOL-Intervention questionnaire. Maturitas. 2005;50(3):209–21. https://doi.org/10.1016/j.maturitas.2004.06.015.

The authors declare that there are no conflicts of interest present.