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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-87</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL LECTURES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ЛЕКЦИИ</subject></subj-group></article-categories><title-group><article-title>BASIC PRINCIPLES OF TREATMENT OF ANEMIA AND THROMBOPHILIC STATUS VIN PREGNANT AND POSTPARTUM WOMEN</article-title><trans-title-group xml:lang="ru"><trans-title>ОСНОВНЫЕ ПРИНЦИПЫ ЛЕЧЕНИЯ АНЕМИИ И ТРОМБОФИЛИЧЕСКОГО СОСТОЯНИЯ У БЕРЕМЕННЫХ И РОДИЛЬНИЦ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>E. S.</given-names></name></name-alternatives><email xlink:type="simple">eesdoctor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>06</month><year>2016</year></pub-date><volume>8</volume><issue>3</issue><fpage>65</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Egorova E.S., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Егорова Е.С.</copyright-holder><copyright-holder xml:lang="en">Egorova E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/87">https://www.gynecology.su/jour/article/view/87</self-uri><abstract><p>The article gives an overview of the forms of anemia, the impact of anemia in pregnancy and obstetric complications. Overwieved the main approaches to the treatment of anemia during pregnancy. A comparative analysis of the use of drugs of ferrous and ferric iron. Discussion of the possibilities given relief thrombophilic conditions in combination with anemia. Formulated the main principles of survey of pregnant women with anemia, as well as the treatment of anemia in pregnant and postpartum women.</p></abstract><trans-abstract xml:lang="ru"><p>В статье дан обзор форм анемии, ее влияние на течение беременности и акушерские осложнения. Рассмотрены основные подходы к лечению анемии во время беременности. Проведен сравнительный анализ эффективности применения препаратов двухвалентного и трехвалентного железа. Дается обсуждение возможностей купирования тромбофилических состояний в сочетании с анемией. Сформулированы основные принципы обследования беременных с анемией, а также лечения анемии у беременных и родильниц.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>АНЕМИЯ БЕРЕМЕННЫХ</kwd><kwd>ЖЕЛЕЗОДЕФИЦИТНАЯ АНЕМИЯ</kwd><kwd>ФОЛИЕВОДЕФИЦИТНАЯ АНЕМИЯ</kwd><kwd>ТРОМБОФИЛИЧЕСКИЕ СОСТОЯНИЯ</kwd><kwd>ПРЕПАРАТЫ ЖЕЛЕЗА</kwd><kwd>ЖЕЛЕЗОСОДЕРЖАЩИЕ КОМПЛЕКСЫ</kwd><kwd>ПРОФИЛАКТИКА ТРОМБОТИЧЕСКИХ ОСЛОЖНЕНИЙ</kwd><kwd>НИЗКОМОЛЕКУЛЯРНЫЙ ГЕПАРИН</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnant anemia</kwd><kwd>iron deficiency anemia</kwd><kwd>folic acid deficiency anemia</kwd><kwd>thrombophilic state</kwd><kwd>iron supplements</kwd><kwd>iron complexes</kwd><kwd>prevention of thrombotic complications</kwd><kwd>low molecular weight heparin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Акиньшина С.В., Макацария А.Д., Бицадзе В.О. Значение оценки системы гемостаза для определения тактики ведения беременности у пациенток с ишемическим инсультом в анамнезе. Акушерство, гинекология и репродукция. 2014; 1: 15-25.</mixed-citation><mixed-citation xml:lang="en">Akin'shina S.V., Makatsariya A.D., Bitsadze V.O. Akusherstvo, ginekologiya i reproduktsiya. 2014; 1: 15-25.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гороховская Г.Н., Зимаева Ю.О., Южанинова О.В. и др. Железодефицитная анемия у беременных. Трудный пациент. 2007; 9: 35-41.</mixed-citation><mixed-citation xml:lang="en">Gorokhovskaya G.N., Zimaeva Yu.O., Yuzhaninova O.V. i dr. Trudnyi patsient. 2007; 9: 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Демихов В.Г. Анемия беременных: дифференциальная диагностика и патогенетическое обоснование терапии. Автореф. дис. ... докт. мед. наук. Рязань. 2003.</mixed-citation><mixed-citation xml:lang="en">Demikhov V.G. Anemiya beremennykh: differentsial’naya diagnostika i patogeneticheskoe obosnovanie terapii. Doct, Diss. (Anemia in pregnancy: differential diagnosis and therapy pathogenetic substantiation). Dr. diss. Ryazan’. 2003.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кашежева А.З., В.С. Ефимов. Лекарственное происхождение гипергомоцистеинемии. Тромбоз, гемостаз, реология. 2001; 3: 14-18.</mixed-citation><mixed-citation xml:lang="en">Kashezheva A.Z., V.S. Efimov. Tromboz, gemostaz, reologiya. 2001; 3: 14-18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Коноводова Е.Н., Бурлев В.А. Железодефицитные состояния у беременных и родильниц. Акушерство и гинекология. 2012; 1: 137-142.</mixed-citation><mixed-citation xml:lang="en">Konovodova E.N., Burlev V.A. Akusherstvo I ginekologiya. 2012; 1: 137-142.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Коноводова Е.Н., Бурлев В.А., Тютюнник В.Л. и др. Эффективность терапии латентного дефицита железа у беременных. Вопросы гинекологии, акушерства и перинатологии. 2011; 10 (5): 26-30.</mixed-citation><mixed-citation xml:lang="en">Konovodova E.N., Burlev V.A., Tyutyunnik V.L. i dr. Voprosy ginekologii, akusherstva i perinatologii. 2011; 10 (5): 26-30.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Лакотко Н.Н. Клинические проявления дефицита железа у женщин в период беременности. Медицинская панорама. 2007; 5 (73): 20-22.</mixed-citation><mixed-citation xml:lang="en">Lakotko N.N. Meditsinskaya panorama. 2007; 5 (73): 20-22.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О. Тромбофилии и противотромботическая терапия в акушерской практике. М. 2003; 185-188, 798-812.</mixed-citation><mixed-citation xml:lang="en">Makatsariya A.D., Bitsadze V.O. Thrombophilia and antithrombotic therapy in obstetric practice [Trombofilii i protivotromboticheskaya terapiya v akusherskoi praktike]. Moscow. 2003; 185-188, 798-812.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О., Баймурадова С.М.,Передеряева Е.Б., Пшеничникова Т.Б., Хизроева Д.Х., Донина Е.В., Акиньшина С.В. Профилактика повторных осложнений беременности в условиях тромбофилии (синдром потери плода, гестозы, преждевременная отслойка нормально расположенной плаценты, тромбозы и тромбоэмболии). Руководство для врачей. М. 2008; 152 с.</mixed-citation><mixed-citation xml:lang="en">Makatsariya A.D., Bitsadze V.O., Baimuradova S.M.,Perederyaeva E.B., Pshenichnikova T.B., Khizroeva D.Kh., Donina E.V., Akin’shina S.V. Prevention of recurrent complications of pregnancy in terms of thrombophilia (fetal loss syndrome, gestational toxicosis, premature detachment of the placenta, thrombosis and thromboembolism). Guidance for doctors [Profilaktika povtornykh oslozhnenii beremennosti v usloviyakh trombofilii (sindrom poteri ploda, gestozy, prezhdevremennaya otsloika normal’no raspolozhennoi platsenty, trombozy I tromboembolii). Rukovodstvo dlya vrachei]. Moscow. 2008; 152 s.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Никитин Е.Н., Долгова О.Н., Шишкина А.А., Юшкова М.В., Манаков В.А. Железодефицитные анемии в разные периоды беременности. Практическая медицина. 2011; 50: 93.</mixed-citation><mixed-citation xml:lang="en">Nikitin E.N., Dolgova O.N., Shishkina A.A., Yushkova M.V., Manakov V.A. Prakticheskaya meditsina. 2011; 50: 93.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Орджоникидзе Н.В., Соколова М.Ю., Сулейманова И.Г. Современные аспекты железодефицитной анемии у беременных (обзор литературы). Проблемы репродукции. 2005; 6.</mixed-citation><mixed-citation xml:lang="en">Ordzhonikidze N.V., Sokolova M.Yu., Suleimanova I.G. Problemy reproduktsii. 2005; 6.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Петухов В.С. Анемия при беременности: современные аспекты проблемы. Охрана материнства и детства. 2009; 1-13: 68-77.</mixed-citation><mixed-citation xml:lang="en">Petukhov V.S. Okhrana materinstva i detstva. 2009; 1-13: 68-77.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Протопопова Т.А. Железодефицитная анемия и беременность. РМЖ. 2012; 17: 862-867.</mixed-citation><mixed-citation xml:lang="en">Protopopova T.A. RMZh. 2012; 17: 862-867.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Савельева Г.М., В.С. Ефимов, А.З. Кашежева. Осложненное течение беременности и гипергомоцистеинемия. Акушерство и гинекология. 2000; 3: 3-5.</mixed-citation><mixed-citation xml:lang="en">Savel’eva G.M., V.S. Efimov, A.Z. Kashezheva. Akusherstvo i ginekologiya. 2000; 3: 3-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Серов В.Н. Анемия при беременности. Клиническая фармакология и терапия. 2005; 14 (2): 78-83.</mixed-citation><mixed-citation xml:lang="en">Serov V.N. Klinicheskaya farmakologiya I terapiya. 2005; 14 (2): 78-83.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Хух Р,. Брейман К. Анемия во время беременности и в послеродовом периоде. М. 2007; 73 с.</mixed-citation><mixed-citation xml:lang="en">Хух Р,. Брейман К. Анемия во время беременности и в послеродовом периоде. М. 2007; 73 с.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barroso F., Allard S., Kahan B.C. et al. Prevalence of maternal anaemia and its predictors: a multi-centre study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011; 2: 179-186.</mixed-citation><mixed-citation xml:lang="en">Barroso F., Allard S., Kahan B.C. et al. Prevalence of maternal anaemia and its predictors: a multi-centre study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011; 2: 179-186.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bencaiova G., von Mandach U., Zimmermann R. Iron prophylaxis in pregnancy: intravenous route versus oral route. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 144 (2): 135-139.</mixed-citation><mixed-citation xml:lang="en">Bencaiova G., von Mandach U., Zimmermann R. Iron prophylaxis in pregnancy: intravenous route versus oral route. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 144 (2): 135-139.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bencaiova G., Burkhardt T., Breymann C. Anemia -prevalence and risk factors in pregnancy. Eur. J. Intern. Med. 2012; 23 (6): 529-533.</mixed-citation><mixed-citation xml:lang="en">Bencaiova G., Burkhardt T., Breymann C. Anemia -prevalence and risk factors in pregnancy. Eur. J. Intern. Med. 2012; 23 (6): 529-533.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Breymann C., Honegger C., Holzgreve W., Surbek D. Diagnosis and treatment of irondeficiency anaemia during pregnancy and postpartum. Arch. Gynecol. Obstet. 2010; 282 (5): 577-580.</mixed-citation><mixed-citation xml:lang="en">Breymann C., Honegger C., Holzgreve W., Surbek D. Diagnosis and treatment of irondeficiency anaemia during pregnancy and postpartum. Arch. Gynecol. Obstet. 2010; 282 (5): 577-580.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bonnar J., Green R., Norris L. Inherited thrombophilia and pregnancy: the obstetric perspective. Semin. Thromb. Hemost. 2008; 24 (1): 49-53.</mixed-citation><mixed-citation xml:lang="en">Bonnar J., Green R., Norris L. Inherited thrombophilia and pregnancy: the obstetric perspective. Semin. Thromb. Hemost. 2008; 24 (1): 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Coumans A.B., Huijgens P.C., Jakobs C., Schats R., de-Vries J.I., van-Pampus M.G., Dekker G.A. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum.Reprod. 2009; 14 (1): 211-214.</mixed-citation><mixed-citation xml:lang="en">Coumans A.B., Huijgens P.C., Jakobs C., Schats R., de-Vries J.I., van-Pampus M.G., Dekker G.A. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum.Reprod. 2009; 14 (1): 211-214.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Casanueva E., Viteri F.E. Iron and Oxidative Stress in Pregnancy. J. Nutr. May 2003; 133: 1700-1708.</mixed-citation><mixed-citation xml:lang="en">Casanueva E., Viteri F.E. Iron and Oxidative Stress in Pregnancy. J. Nutr. May 2003; 133: 1700-1708.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Critchley J, Bates I.. Haemoglobin colour scale for anaemia diagnosis where there is no laboratory: a systematic review. Int. J. Epidemiol. 2005; 34: 1425-1434.</mixed-citation><mixed-citation xml:lang="en">Critchley J, Bates I.. Haemoglobin colour scale for anaemia diagnosis where there is no laboratory: a systematic review. Int. J. Epidemiol. 2005; 34: 1425-1434.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kochhar P.K., Kaundal A., Ghosh P. Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: A randomized clinical trial. J. Obstet. Gynaecol. Res. 2012; 26: 1-7.</mixed-citation><mixed-citation xml:lang="en">Kochhar P.K., Kaundal A., Ghosh P. Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: A randomized clinical trial. J. Obstet. Gynaecol. Res. 2012; 26: 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Pasricha S.R., Flecknoe-Brown S.C., Allen K.J. et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med. J. Aust. 2010; 193 (9): 525-532.</mixed-citation><mixed-citation xml:lang="en">Pasricha S.R., Flecknoe-Brown S.C., Allen K.J. et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med. J. Aust. 2010; 193 (9): 525-532.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Powers R.W., Evans R.W., Majors A.K., Ojimba J.I., Ness R.B., Crombleholme W.R., Roberts J.M. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am. J. Obstet.Gynecol. 2005; 179 (6 Pt 1): 1605-1511.</mixed-citation><mixed-citation xml:lang="en">Powers R.W., Evans R.W., Majors A.K., Ojimba J.I., Ness R.B., Crombleholme W.R., Roberts J.M. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am. J. Obstet.Gynecol. 2005; 179 (6 Pt 1): 1605-1511.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Shao J., Lou J, Rao R. et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J. Nutr. 2012; 142 (11): 2004-2009. 29. V. De Stefano, G.Finazzi, P.M.Mannucci. Inherited thrombophilia: Pathogenesis, clinical syndromes and management. Blood. 2006; 87 (9): 3531-3544.</mixed-citation><mixed-citation xml:lang="en">Shao J., Lou J, Rao R. et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J. Nutr. 2012; 142 (11): 2004-2009. 29. V. De Stefano, G.Finazzi, P.M.Mannucci. Inherited thrombophilia: Pathogenesis, clinical syndromes and management. Blood. 2006; 87 (9): 3531-3544.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Van-Pampus M.G., Dekker G.A., Wolf H., Huijgens P.C., Koopman M.M., von-Blomberg B.M., Buller H.R. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am. J. Obstet. Gynecol. 2004; 180 (5): 1146-1150.</mixed-citation><mixed-citation xml:lang="en">Van-Pampus M.G., Dekker G.A., Wolf H., Huijgens P.C., Koopman M.M., von-Blomberg B.M., Buller H.R. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am. J. Obstet. Gynecol. 2004; 180 (5): 1146-1150.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
