References

akusherstvo

Obstetrics, Gynecology and Reproduction

Акушерство, Гинекология и Репродукция

2313-73472500-3194

IRBIS LLC

10.17749/2313-7347/ob.gyn.rep.2020.195

akusherstvo-866

Research Article

REVIEW ARTICLES

НАУЧНЫЕ ОБЗОРЫ

Current trends in the pharmacotherapy of uterine myoma, associated with heavy menstrual bleeding and anemia: a literature review

Современные тенденции в фармакотерапии миомы матки, сопровождающейся обильными менструальными кровотечениями и анемией: литературный обзор

https://orcid.org/0000-0002-5466-2881

Ревазова

З. В.

Revazova

Z. V.

Ревазова Зарина Валерьевна - кандидат медицинских наук, врач акушер-гинеколог, старший лаборант кафедры репродуктивной медицины и хирургии факультета дополнительного профессионального образования.127473 Москва, ул. Делегатская, д. 20, стр. 1.

Zarina V. Revazova - MD, PhD, Obstetrician-Gynecologist, Research Technician, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, Evdokimov Moscow State University of Medicine and Dentistry.20/1 Delegatskaya Str., Moscow 127473.

atias@bk.ru

https://orcid.org/0000-0002-3253-4512

Адамян

Л. В.

Adamyan

L. V.

Адамян Лейла Владимировна - доктор медицинских наук, профессор, академик РАН, зав. кафедрой репродуктивной медицины и хирургии факультета дополнительного профессионального образования МГМСУ им. А.И. Евдокимова МЗ РФ; заместитель директора по научной работе НМИЦ АГП им. В.И. Кулакова МЗ РФ; заслуженный деятель науки РФ, главный специалист по акушерству и гинекологии Министерства здравоохранения Российской Федерации.127473 Москва, ул. Делегатская, д. 20, стр. 1; 117997 Москва, ул. Академика Опарина, д. 4

Leyla V. Adamyan - MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, Evdokimov Moscow State University of Medicine and Dentistry; Director for Science, Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology; Honored Scientist of the Russian Federation, Chief Specialist in Obstetrics and Gynecology of Health Ministry of Russian Federation.20/1 Delegatskaya Str., Moscow 127473; 4, Academika Oparina Str., Moscow 117997.

https://orcid.org/0000-0003-3862-1411

Логинова

О. Н.

Loginova

O. N.

Логинова Ольга Николаевна - кандидат медицинских наук, доцент кафедры репродуктивной медицины и хирургии факультета дополнительного профессионального образования.127473 Москва, ул. Делегатская, д. 20, стр. 1.

Olga N. Loginova - MD, PhD, Associate Professor, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, Evdokimov Moscow State University of Medicine and Dentistry.20/1 Delegatskaya Str., Moscow 127473.

https://orcid.org/0000-0001-8395-7534

Манукян

Л. М.

Manukyan

L. M.

Манукян Лиана Микаеловна - кандидат медицинских наук, врач акушер-гинеколог, старший лаборант кафедры репродуктивной медицины и хирургии факультета дополнительного профессионального образования.127473 Москва, ул. Делегатская, д. 20, стр. 1.

Liana M. Manukyan - MD, PhD, Obstetrician-Gynecologist, Research Technician, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, Evdokimov Moscow State University of Medicine and Dentistry.20/1 Delegatskaya Str., Moscow 127473.

https://orcid.org/0000-0001-6146-830X

Арсланян

К. Н.

Arslanyan

K. N.

Арсланян Каринэ Норайровна - кандидат медицинских наук, доцент кафедры репродуктивной медицины и хирургии факультета дополнительного профессионального образования.127473 Москва, ул. Делегатская, д. 20, стр. 1.

Karine N. Arslanyan - MD, PhD, Associate Professor, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, Evdokimov Moscow State University of Medicine and Dentistry.20/1 Delegatskaya Str., Moscow 127473.

Московский государственный медико-стоматологический университет имени А.И. Евдокимова Министерства здравоохранения Российской ФедерацииРоссияEvdokimov Moscow State University of Medicine and Dentistry, Health Ministry of Russian FederationRussian Federation

Московский государственный медико-стоматологический университет имени А.И. Евдокимова Министерства здравоохранения Российской Федерации; Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова Министерства здравоохранения Российской ФедерацииРоссияEvdokimov Moscow State University of Medicine and Dentistry, Health Ministry of Russian Federation; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationRussian Federation

2021

24122020

1518092

2021

Ревазова З.В., Адамян Л.В., Логинова О.Н., Манукян Л.М., Арсланян К.Н.

Revazova Z.V., Adamyan L.V., Loginova O.N., Manukyan L.M., Arslanyan K.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gynecology.su/jour/article/view/866

Aim: to summarize up-to-date world data on current opportunities of drug therapy in treatment of symptomatic myoma accompanied with heavy menstrual bleeding and anemia.Materials and Methods. A search of publications was carried out in the main international databases published in Russian and English: PubMed/MEDLINE, The Cochrane Library, Embase, and eLibrary. The analysis included studies published over the last 10 years examining the clinical efficacy and safety of various groups of pharmacological agents used for treatment of uterine myoma combined with heavy menstrual bleeding in women of reproductive age.Results. Currently, treatment of uterine fibroids consists of the three major approaches: surgical, minimally invasive organpreserving methods, and pharmacotherapy. Until now, surgical intervention remains the main method of treatment, unfortunately being often performed in a foem of hysterectomy. However, today it is important to apply a personalized approach to the management of a female patient with symptomatic uterine myoma, taking into account her wish to preserve reproductive function. Advances in drug therapy greatly contributed to optimizing management of such patients.Conclusion. Treatment of symptomatic uterine fibroids globally tends to lowering the number of radical interventions, as well as develop and improve new therapeutic approaches for. Currently, pharmacotherapy of leiomyoma can substantially improve the quality of patients' life, lower number of radical surgical interventions, optimize surgical treatment, and even fully negate, in some cases, a need for surgery.

Цель исследования: обобщение мировых данных о современных возможностях медикаментозной терапии миомы матки, сопровождающейся обильными менструальными кровотечениями (ОМК) и анемией.Материалы и методы. Выполнен поиск публикаций в основных международных базах на русском и английском языках: PubMed/MEDLINE, The Cochrane Library, Embase, eLibrary. В анализ включались исследования, опубликованные за последние 10 лет, в которых изучались клиническая эффективность и безопасность различных групп фармакологических препаратов для лечения миомы матки, сочетающейся с ОМК, у женщин репродуктивного возраста.Результаты. В настоящее время в лечении миомы матки используются 3 основных метода: хирургический, малоинвазивные органосохраняющие методы и медикаментозная терапия. До сих пор оперативное вмешательство остается основным методом лечения и, к сожалению, нередко проводится в объеме гистерэктомии. Однако на сегодняшний день важен персонифицированный подход к ведению пациентки с симптомной миомой матки с учетом ее желания сохранить репродуктивную функцию. Большой вклад в оптимизацию тактики ведения таких пациенток внесло развитие возможностей медикаментозной терапии.Заключение. Общемировой тенденцией является снижение количества радикальных вмешательств, в также развитие и усовершенствование новых методов лечения миомы матки, сопровождающейся ОМК и анемией. В настоящее время фармакотерапия лейомиомы позволяет существенно повысить качество жизни пациенток, снизить проведение радикальных оперативных вмешательств, оптимизировать хирургическое лечение, в определенных ситуациях и вовсе исключить необходимость операции.

миома маткилейомиомамиомэктомияобильные менструальные кровотеченияменоррагияанемиямедикаментозная терапия

uterine myomafibroidmyomectomyheavy menstrual bleedinganemiamyoma treatment

Работа проведена при финансовой поддержке гранта Президента Российской Федерации для государственной поддержки молодых российских ученых № МК-2836.2019.7 на тему «Клинико-морфологическое обоснование новых возможностей ведения больных с миомой матки, сопровождающейся обильными менструальными кровотечениями».

The work was carried out with the financial support of the grant of the President of the Russian Federation for state support of young Russian scientists № MK-2836.2019.7 on the topic "Clinical and morphological substantiation of new possibilities for the management of patients with uterine fibroids accompanied by heavy menstrual bleeding".

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The authors declare that there are no conflicts of interest present.