akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-85Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИTHE ANTIOXIDATIVE DEFENCE IN WOMEN WITH EXTERNAL ENDOMETRIOSISАНТИОКСИДАНТНАЯ ЗАЩИТА У БОЛЬНЫХ НАРУЖНЫМ ГЕНИТАЛЬНЫМ ЭНДОМЕТРИОЗОМАдамянЛ. В.AdamyanL. V.ЛогиноваО. Н.LoginovaO. N.poddubnay@ya.ruСоноваМ. М.SonovaM. M.АрсланянК. Н.ArslanyanK. N.ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РФРоссияMoscow State University of Medicine and DentistryRussian Federation201408062016831821Copyright © Adamyan L.V., Loginova O.N., Sonova M.M., Arslanyan K.N., 20162016Адамян Л.В., Логинова О.Н., Сонова М.М., Арсланян К.Н.Adamyan L.V., Loginova O.N., Sonova M.M., Arslanyan K.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/85

We studied the indexes of antioxidative defence – the concentration of active form of enzymes ceruloplasmin (CP) and transferin (TF) and NO-capacity of the protein of blood in 60 women with external endometriosis by method spectroscopy. The concentration of active form of ceruloplasmin was increased and the concentration of transferin was decreased in women with external endometriosis; the index CP/TF was increased. The NO-connective capacity of theblood was significant increased in this group of women comparing with their relatives and the control (healthy women) group. These changes are the result of the breach of balance in the system oxidant\antioxidant and the development of oxidative stress in this group of women.

Нами изучались показатели антиоксидантной защиты - отношение концентраций активных форм ферментов церулоплазмина (ЦП) и трансферрина (ТФ) и NO-связывающей способности SH-групп белков крови у 60 больных наружным эндометриозом методом ЭПР-спектроскопии плазмы крови. У пациенток, страдающих наружной формой эндометриоза, выявлено повышение концентрации в крови активной формы ЦП и снижение концентрации активной формы ТФ (повышение показателя ЦП/ТФ); а также значительно снижена NO-связывающая способность крови по сравнению с их родственницами и практически здоровыми женщинами. Данные изменения свидетельствует о нарушении баланса в системе оксидант/антиоксидант и о развитии окислительного стресса у обследуемой группы больных.

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The authors declare that there are no conflicts of interest present.