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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-84</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ОRIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>CLINICAL AND IMMUNOLOGICAL COURSE OF GESTATION DURING PREGNANCY INDUCED HYPERTENSION</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИКО-ИММУНОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ БЕРЕМЕННОСТИ ПРИ ГИПЕРТЕНЗИВНЫХ СОСТОЯНИЯХ, ВЫЗВАННЫХ БЕРЕМЕННОСТЬЮ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шахбазова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakhbazova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">shahbazova.70@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский Институт Акушерства и Гинекологии (Баку, Азербайджан)</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>Scientific-Research Institute of Obstetrics and Gynecology (Baku, Azerbaijan)</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>08</day><month>06</month><year>2016</year></pub-date><volume>8</volume><issue>3</issue><fpage>11</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shakhbazova N.A., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Шахбазова Н.А.</copyright-holder><copyright-holder xml:lang="en">Shakhbazova N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/84">https://www.gynecology.su/jour/article/view/84</self-uri><abstract><p>The aim of this research was studies character of clinical course of gestation and immunological markers in pregnant women with gestational hypertension and pre-eclampsia. In150 pregnant women with gestational hypertension and pre-eclampsia (basic group I) and 50 healthy pregnant women at the same gestational period (control group) was studies clinical course of gestation and plazma levels of twelve natural autoantibodies. The levels of autoantibodies throughout pregnancy were analyzed with an ELISA assay. First gestational trimester with hypertensive disorders accompanied with different complications in 62% of cases ,every second woman (50%) has complications during second trimester while pregnancy-induced hypertension and third trimester at pregnancy-induced hypertension has complications in 56,7% of cases ,and every third woman has fetoplacental insufficiency. The levels of В-2QP, S-100 and ANCA autoantibodies increase during pregnancy in women with gestational hypertension and pre-eclampsia. Quantification of the value of the level of autoantibodies directly depends on the severity of hypertensive disorders.</p></abstract><trans-abstract xml:lang="ru"><p>Целью настоящего исследования явилось изучение характера течения беременности по триместрам и определение в крови уровня некоторых регуляторных аутоантител у пациенток с гипертензивными расстройствами, вызванными беременностью. Были изучены осложнения беременности и уровень 12 естественных аутоантител у 150 беременных с гипертензивными состояниями, вызванными беременностью (I основная группа), и у 50 здоровых беременных в эти же сроки гестации (контрольная группа). Уровень аутоантител определяли с помощью твердофазного иммуноферментного анализа набором реагентов «ЭЛИ-П-Комплекс-12». Для оценки связи между качественными признаками применялся критерий Пирсона χ². В ходе исследования было установлено, что раннее начало гипертензивных расстройств при беременности характеризуется более тяжелым течением заболевания. У женщин с гипертензивными нарушениями первый триместр беременности сопровождается различными осложнениями в 62% случаев, во втором триместре осложнения отмечаются у каждой второй беременной (50%), в третьем триместре - в 56,7% случаев, причем у каждой третьей беременной имеет место фетоплацентарная недостаточность. Установлено повышение уровня антител к антигенам В-2QP, S-100 и ANCA. Количественная величина уровня аутоантител напрямую зависит от степени тяжести гипертензивных расстройств.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>БЕРЕМЕННОСТЬ</kwd><kwd>ГЕСТАЦИОННАЯ ГИПЕРТЕНЗИЯ</kwd><kwd>ПРЕЭКЛАМПСИЯ</kwd><kwd>АУТОАНТИТЕЛА</kwd><kwd>ФЕТОПЛАЦЕНТАРНАЯ НЕДОСТАТОЧНОСТЬ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>pregnancy-induced hypertension</kwd><kwd>preeclampsia</kwd><kwd>autoantibodies</kwd><kwd>fetoplacental insuffici</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Макаров О.В., Ткачева О.Н., Волкова Е.В. Преэклампсия и хроническая артериальная гипертензия. Клинические аспекты. М. 2010; 136 с.</mixed-citation><mixed-citation xml:lang="en">Makarov O.V., Tkacheva O.N., Volkova E.V. Pre-eclampsia and chronic hypertension. Clinical aspects [Preeklampsiya i khronicheskaya arterial’naya gipertenziya. Klinicheskie aspekty]. 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