akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-82Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORYК ВОПРОСУ О НАРУШЕНИЯХ В СИСТЕМЕ ПРОТЕИНА С С РАЗНООБРАЗНОЙ АКУШЕРСКОЙ ПАТОЛОГИЕЙ В АНАМНЕЗЕ У БЕРЕМЕННЫХМихайлидиИ. А.MikhaylidiI. A.arkhimedovna@mail.ruГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, МоскваРоссияThe State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian FederationRussian Federation201408062016835964Copyright © Mikhaylidi I.A., 20162016Михайлиди И.А.Mikhaylidi I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/82

This article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant property, aPC demonstrates anti-inflammatory and cytoprotectiveeffects, which are mediated through the endothelial protein C receptor and the protease-activated receptor-I (PAR-1). Studying and understanding the biological function of APS makes it possible to control coagulation and inflammation and to apply protein C preparations as anticoagulant and cytoprotective drugs in a physicians clinicalpractice.

Активированный протеин С (АРС), взаимодействуя с эндотелиальным рецептором протеина С (EPCR), рецепторами, активизируемыми протеазами (PAR), рецептором аполипопротина Е2 и интегринами, оказывает различные эффекты на систему гемостаза (антикоагулянтный эффект) и иммунную систему организма (цитопротекторный эффект). Значение системы протеина С лучше всего демонстрируется противотромботическими и воспалительными осложнениями, обусловленными дефицитом протеина С или нарушением его функции, которые в клинической практике проявляются в виде ишемического инсульта, воспалительных заболеваний, атеросклероза, сосудистых осложнений и акушерских проблем. Изучение и понимание биологической функции АРС позволяет осуществлять контроль над свертыванием и воспалением и найти применение препарата протеина С в качестве антикоагулянта и цитопротектора в клинической практике врача.

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The authors declare that there are no conflicts of interest present.