akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-81Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРVENOUS THROMBOEMBOLISM IN RELATION TO OVARIAN HYPERSTIMULATION SYNDROME: AN APPROACH TO DETERMINING THE LOW-MOLECULAR-WEIGHT-HEPARIN DOSES AND ACTIVITYК ВОПРОСУ О ВЫБОРЕ ДОЗЫ И МЕТОДА ОЦЕНКИ АКТИВНОСТИ НИЗКОМОЛЕКУЛЯРНЫХ ГЕПАРИНОВ ДЛЯ ПРОФИЛАКТИКИ ВЕНОЗНЫХ ТРОМБЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ В КОМПЛЕКСНОЙ ТЕРАПИИ СИНДРОМА ГИПЕРСТИМУЛЯЦИИ ЯИЧНИКОВЗазерскаяИ. Е.ZazerskayaI. E.ОсиповаН. А.OsipovaN. A.naosipova@mail.ruВавиловаТ. В.VavilovaT. V.БарабановаЛ. В.BarabanovaL. V.КонрадиК. С.KonradiK. S.ФГБУ ФМИЦ им. В.А. Алмазова, Санкт-ПетербургРоссияAlmazov Federal Heart, Blood and Endocrinology Centre, Saint-PetersburgRussian Federation201408062016835358Copyright © Zazerskaya I.E., Osipova N.A., Vavilova T.V., Barabanova L.V., Konradi K.S., 20162016Зазерская И.Е., Осипова Н.А., Вавилова Т.В., Барабанова Л.В., Конради К.С.Zazerskaya I.E., Osipova N.A., Vavilova T.V., Barabanova L.V., Konradi K.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/81

Ovarian hyperstimulation syndrome (OHSS) is a relatively common complication of ovarian stimulation. The pathophysiology of OHSS is characterised by increased capillary permeability. As a consequence of this, there is a fluid shift into third-space causing hemoconcentration, it may contribute to hypercoagulable state, with increased riskof venous thromboembolism. The article presents modern data on prevention of thromboembolic complication in OHSS patients with special focus on dosage and duration of thromboprophylaxis.

Синдром гиперстимуляции яичников (СГЯ) - ятрогенное осложнение, проявляющееся в виде гиперергической реакции яичников на применяемые стимуляторы овуляции. В основе клинических проявлений СГЯ лежит резкое повышение сосудистой проницаемости, приводящее к массивному выходу жидкости в межклеточное пространство. Активная экссудация плазмы крови наряду с системной воспалительной реакцией обусловливает в т.ч. развитие гемоконцентрации, повышающей риск тромбозов. В настоящей статье приведены данные современной литературы относительно выбора дозы и длительности применения низкомолекулярных гепаринов для профилактики венозных тромбэмболических осложнений у пациенток с СГЯ.

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The authors declare that there are no conflicts of interest present.