akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-80Research ArticleCLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙPREGNANCY AND CHILDBIRTH IN A YOUNG WOMAN WITH CONCOMITANT MUTATION IN LEIDEN AND PROTHROMBIN GENE G20210AБЕРЕМЕННОСТЬ И РОДЫ У МОЛОДОЙ ЖЕНЩИНЫ С СОЧЕТАННОЙ МУТАЦИЕЙ ЛЕЙДЕНА И В ГЕНЕ ПРОТРОМБИНА G20210AКапанадзеД. Л.KapanadzeD. L.daka.kapanadze@yandex.ruГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, МоскваРоссияFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationRussian Federation201407062016823438Copyright © Kapanadze D.L., 20162016Капанадзе Д.Л.Kapanadze D.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/80

Pregnancy and childbirth in women with genetic or acquired thrombophilia is usually associated with a high risk to both thrombotic and obstetric complications and fruit. Unambiguous answer to the question of routine screening for thrombophilia in women with a history of obstetric history does not exist until now. It should be noted that the physiological hypercoagulable inherent pregnant, often for the first time reveals the background congenital and / or acquired disorders of hemostasis, which previously could be asymptomatic. A history of fetal loss syndrome, severe obstetric complications (severe preeclampsia, severe  twin-platsentranoy failure, fetal death, premature detachment of the placenta), thromboembolism is an indication for the study of genetic thrombophilia and antiphospholipid syndrome.

Беременность и роды у женщин с генетическими и приобретенными формами тромбофилии обычно сопряжены с высоким риском как тромботических, так и акушерских и плодовых осложнений. Однозначного ответа на вопрос о рутинном обследовании на наличие тромбофилии у женщин с отягощенным акушерским анамнезом не существует до сих пор. Следует отметить, что физиологическая гиперкоагуляция, свойственная беременным, часто впервые выявляет фоновые врожденные и/или приобретенные нарушения в системе гемостаза, которые ранее могли быть бессимптомными. Наличие в анамнезе синдрома потери плода, тяжелых акушерских осложнений (тяжелых форм гестоза, тяжелой фетоплацентраной недостаточности, антенатальной гибели плода, преждевременной отслойки плаценты), тромбоэмболий является показанием к исследованию на генетические формы тромбофилии и антифосфолипидный синдром.

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The authors declare that there are no conflicts of interest present.