akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2020.140akusherstvo-798Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫOne of the trends of oxidative protection in in vitro fertilization programsОдин из трендов оксидативной протекции в программах экстракорпорального оплодотворенияhttps://orcid.org/0000-0001-5069-8177ВахловаО. С.VachlovaO. S.

Вахлова Олеся Сергеевна – аспирант кафедра акушерства и гинекологии; врач акушер-гинеколог

Россия, 620219 Екатеринбург, ул. Репина, д. 3

Россия, 620026, Екатеринбург, ул. Белинского, д. 61

Olesya S. Vachlova – MD, Postgraduate Student, Department of Obstetrics and Gynecology; Obstetrician-Gynecologist

3 Repin Str., Ekaterinburg 620219, Russia

61 Belinsky Str., Ekaterinburg 620026, Russia

dr.vakhlova@mail.ruhttps://orcid.org/0000-0003-0711-7896ОбоскаловаТ. А.OboskalovaT. A.

Обоскалова Татьяна Анатольевна – д. м.н., профессор, зав. кафедрой акушерства и гинекологии

Россия, 620219 Екатеринбург, ул. Репина, д. 3

Tatyana A. Oboskalova – MD, Dr Sci Med, Professor, Head of the Department of Obstetrics and Gynecology

3 Repin Str., Ekaterinburg 620219, Russia

ФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации; АО Центр реабилитации нарушений репродуктивной функции «Партус»РоссияUral State Medical University, Health Ministry of Russian Federation; JSC Rehabilitation Center for Reproductive Disorders «Partus»Russian FederationФГБОУ ВО «Уральский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияUral State Medical University, Health Ministry of Russian FederationRussian Federation202014102020144502514Copyright © Vachlova O.S., Oboskalova T.A., 20202020Вахлова О.С., Обоскалова Т.А.Vachlova O.S., Oboskalova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/798

Here we review published data from experimental and clinical international studies examining pathogenetic effects of melatonin upon using programs of In Vitro Fertilization (IVF); highlighting various viewpoints on its biological action as a regulator of circadian rhythms: on the one hand, the inhibitory effect of melatonin on pulsating secretion of gonadotropin-releasing hormone was considered, thereby achieving a contraceptive effect; on the other hand, its ability to induce the secretion of human chorionic gonadotropin ensuring ovulation process, was discussed. We also review the data on melatonin acting as a highly active antioxidant. While using melatonin as a metabolic supplement in IVF programs, its positive effect on oocyte morphology and quality of fertilization, embryo division was observed. Moreover, we also highlight the results of studies examining melatonin-related effects on quality of fertilization and embryo division after adding it to culture medium. Such effects demonstrated dose-depended pattern. Taking into account the data of the analyzed publications, adding exogenous melatonin to culture medium may represent a new strategy for personalized approach to improve outcome of IVF programs. Its effectiveness should be further investigated and considered for introduction within the framework of pregravid preparation.

В литературном обзоре представлены результаты экспериментальных и клинических международных исследований о патогенезе действия мелатонина при использовании в программах вспомогательных репродуктивных технологий, освещаются различные точки зрения его биологического эндогенного действия как регулятора циркадных ритмов: с одной стороны, рассматривается ингибирующее влияние мелатонина на пульсирующую секрецию гонадотропин-рилизинг гормона, за счет чего достигается контрацептивный эффект; с другой стороны, обсуждаются данные о его способности индуцировать секрецию хорионического гонадотропина, обеспечивая процесс овуляции. В обзоре представлены данные о мелатонине как о высокоактивном антиоксиданте. При использовании мелатонина в качестве метаболической дотации в программах экстракорпорального оплодотворения (ЭКО) прослеживается его положительное влияние на морфологию ооцитов, качество оплодотворения и деление эмбрионов. В настоящем обзоре приведены результаты исследований влияния мелатонина на качество оплодотворения и деления эмбрионов при условии его добавления в культуральную среду. Достигнутые эффекты имели дозазависимый характер. С учетом обобщенных данных добавление экзогенного мелатонина может являться новой стратегией персонифицированного подхода по улучшению исходов программ ЭКО. Эффективность его применения должна быть дополнительно исследована и рассмотрена к внедрению в рамках прегравидарной подготовки.

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The authors declare that there are no conflicts of interest present.