akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2020.167akusherstvo-782Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫA systematic analysis of vascular paroxysm pathophysiology in perimenopause: methods for nutritional correctionСистематический анализ патофизиологии сосудистых пароксизмов в перименопаузе: нутрицевтические методы коррекцииhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна - д. м.н., профессор, ведущий научный сотрудник, научный руководитель

119333 Москва, ул. Вавилова, д. 42

119234 Москва, Ленинские горы, д. 1

Scopus Author ID: 7003589812

Researcher ID: J-4946-2017

Author ID: 94901

WOS ID: J-4946-2017

Olga A. Gromova - MD, Dr Sci Med, Professor, Leading Researcher, Scientific Director

42 Vavilova Str., Moscow 119333

1 Leninskie gory, Moscow 119234

Scopus Author ID: 7003589812

Researcher ID: J-4946-2017

Author ID: 94901. WOS ID: J-4946-2017

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич - к.ф-м.н., к. х.н., старший научный сотрудник

119333 Москва, ул. Вавилова, д. 42

119234 Москва, Ленинские горы, д. 1

Scopus Author ID: 7003300274

Researcher ID: C-7683-2018

Author ID: 54104

WOS ID: C-7683-2018

Ivan Yu. Torshin - PhD (Chemistry), PhD in Applied Mathematics, Senior Researcher

42 Vavilova Str., Moscow 119333

1 Leninskie gory, Moscow 119234

Scopus Author ID: 7003300274

Researcher ID: C-7683-2018

Author ID: 54104

WOS ID: C-7683-2018

https://orcid.org/0000-0002-2342-3036ЛимановаО. А.LimanovaO. A.

Лиманова Ольга Адольфовна - к. м.н., доцент кафедры фармакологии

153012 Иваново, Шереметьевский пр., д. 8

Olga A. Limanova - MD, PhD, Associate Professor, Department of Pharmacology

8 Sheremetyevskiy Ave., Ivanovo 153012

Scopus Author ID: 23013489000

WoS ID: A-7504-2016

https://orcid.org/0000-0001-5309-0087ТапильскаяН. И.TapilskayaN. I.

Тапильская Наталья Игоревна - д. м.н., профессор, ведущий научный сотрудник отделения вспомогательных репродуктивных технологий

199034 Санкт-Петербург, Менделеевская линия, д. 3

194100 Санкт-Петербург, ул. Литовская, д. 2

Scopus Author ID: 23013489000

WoS ID: A-7504-2016

 

Natalia I. Tapilskaya - MD, Dr Sci Med, Professor, Leading Researcher, Department of Assisted Reproductive Technologies; Professor, Department of Obstetrics and Gynecology

3 Mendeleevskaya liniya, Saint Petersburg 199034

2 Litovskaya Str., Saint Petersburg 194100

Scopus Author ID: 23013489000

WoS ID: A-7504-2016

Институт фармакоинформатики ФГБУ «Федеральный исследовательский центр “Информатика и управление” Российской академии наук»; Центр хранения и анализа больших данных ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияInstitute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State UniversityRussian FederationФГБОУ ВО «Ивановская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияIvanovo State Medical Academy, Health Ministry of Russian FederationRussian FederationФГБНУ «Научно исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияResearch Institute of Obstetrics, Gynecology and Reproductology named after D. O. Ott; Saint Petersburg State Pediatric Medical University, Health Ministry of Russian FederationRussian Federation202024092020143361373Copyright © Gromova O.A., Torshin I.Y., Limanova O.A., Tapilskaya N.I., 20202020Громова О.А., Торшин И.Ю., Лиманова О.А., Тапильская Н.И.Gromova O.A., Torshin I.Y., Limanova O.A., Tapilskaya N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/782Materials and Methods

Materials and Methods. A systematic analysis of publications retrieved from PubMed/MEDLINE database as well as in the list of primary sources of the identified scientific papers was carried out by using current methods for large data analysis within the framework of topological and metric approaches applied for data recognition/classification. A map of molecular-pathophysiological processes was compiled followed by performing analysis of metric condensations.

Results

Results. Three clusters of terms describing an impact of various biological processes into the pathophysiology of hot flushes were identified: inflammation combined with insulin resistance (cluster 1), the presence of chronic comorbid pathologies in patients (cluster 2), and disorders of serotonin metabolism (cluster 3). The use of menopausal hormone therapy (MHT) is not accepted for all patients. A promising direction in treatment of mild and moderate hot flushes is based on using nutraceuticals: vitamins, trace elements and substances obtained from plant extracts (isoflavones, phytoestrogens, etc.). Here, this set of interactions between pathophysiology of hot flushes and deficiency of certain micronutrients, inflammation, insulin resistance, chronic comorbid pathologies and disorders of serotonin metabolism is described. Replenished deficiency of vitamins C, E, A, B2, PP, B6, B12, and folates aids to reduce chronic inflammation, insulin resistance and normalize functioning of the autonomic nervous system. Natural and synthetic agonists of GABA receptors and tryptophan derivatives are necessary for serotonin biosynthesis and elimination of other neurotransmitter imbalances in order to normalize activity of the hypothalamic thermoregulatory region.

Conclusion

Conclusion. Plant isoflavones (including phytoestrogens) together with vitamins and other micronutrients help to overcome estrogen-dependent withdrawal symptoms and eliminate dysfunction of autonomic nervous system

Цель

Цель: выполнить систематический анализ патофизиологических ролей микронутриентов и витаминоподобных веществ в контроле приливов.

Материалы и методы

Материалы и методы. Выполнен систематический анализ публикаций в PubMed/MEDLINE, а также в списках первоисточников идентифицированных научных статей с использованием современных методов анализа больших данных, развиваемых в рамках топологического и метрического подходов к задачам распознавания/классификации. Составлена карта молекулярно-патофизиологических процессов, выполнен анализ метрических сгущений.

Результаты

Результаты. Выделено 3 кластера терминов, описывающих вклад различных биологических процессов в патофизиологию приливов: воспаление в сочетании с инсулинорезистентностью (кластер 1), наличие у пациентки хронических коморбидных патологий (кластер 2), нарушения обмена серотонина (кластер 3). Применение менопаузальной гормональной терапии (МГТ) приемлемо не для всех пациенток. Перспективным направлением в терапии легких и умеренных приливов является использование нутрицевтиков: витаминов, микроэлементов и веществ, получаемых из растительных экстрактов (изофлавоны, фитоэстрогены и др.). Описан комплекс взаимодействий между патофизиологией приливов и дефицитами определенных микронутриентов, воспалением, инсулинорезистентностью, хроническими коморбидными патологиями и нарушениями обмена серотонина. Восполнение недостаточности витаминов С, Е, А, В2, РР, В6, В12, фолатов способствует снижению хронического воспаления, инсулинорезистентности и нормализации функционирования вегетативной нервной системы. Природные и синтетические агонисты ГАМК-рецепторов, производные триптофана, необходимые для биосинтеза серотонина, устраняют нарушения баланса нейротрансмиттеров и нормализуют активность терморегуляторной зоны гипоталамуса.

Заключение

Заключение. Растительные изофлавоны (в том числе фитоэстрогены) способствуют преодолению эстроген-зависимой абстиненции и устранению вегетативной дисфункции.

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The authors declare that there are no conflicts of interest present.