akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-65Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРANTIPHOSPHOLIPID ANTIBODIES, THEIR PATHOGENETIC AND DIAGNOSTIC ISSUES OBSTETRIC PRACTICEАНТИФОСФОЛИПИДНЫЕ АНТИТЕЛА, ИХ ПАТОГЕНЕТИЧЕСКОЕ И ДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ПРИ АКУШЕРСКОЙ ПАТОЛОГИИБицадзеВ. О.BitsadzeV. O.ХизроеваД. Х.KhizroevaD. Kh.gemostasis@mail.ruМакацарияН. А.MakatsariyaN. A.ЕгороваЕ. С.EgorovaE. S.БаймурадоваС. М.BaymuradovaS. M.МашковаТ. Я.MashkovaT. Ya.ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, МоскваРоссияFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationRussian Federation201407062016823960Copyright © Bitsadze V.O., Khizroeva D.K., Makatsariya N.A., Egorova E.S., Baymuradova S.M., Mashkova T.Y., 20162016Бицадзе В.О., Хизроева Д.Х., Макацария Н.А., Егорова Е.С., Баймурадова С.М., Машкова Т.Я.Bitsadze V.O., Khizroeva D.K., Makatsariya N.A., Egorova E.S., Baymuradova S.M., Mashkova T.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/65

Not only thrombotic, but also “non-thrombotic” mechanisms of antiphospholipid antibodies are being actively studied in regard to their impact on the structure of reproductive losses and other complications of pregnancy. Non-thrombotic effects of APA include the damage of cells, the induction of apoptosis, the inhibition of proliferation, the suppression of human chorionic gonadotropin, the interference to the invasion of the trophoblast, and defectsof differentiation of the endometrium. Thrombotic effects are: widespread thrombosis, placental infarction, disruption of the annexin barrier, and anti-b2GPI and APC resistance.

Антифосфолипидные антитела оказывают многогранное влияние на систему гемостаза, повреждая все его защитные звенья: эндотелиальный барьер, функцию естественных антикоагулянтов, эндогенный фибринолиз и активируя тромбоцитарное звено гемостаза и прокоагулянтные факторы. Сочетание протромботических и нетромботических эффектов, включая активацию локального воспалительного ответа, влияние на трофобласт и характеристики эмбриона, приводят к развитию характерной клинической картины - целому спектру тромботических осложнений в артериальных, венозных сосудах, в системе микроциркуляции по типу ангиопатии, а также к репродуктивным потерям и тяжелым поздним акушерским осложнениям, таким как гестоз и преэкламсия, фетоплацентарная недостаточность, задержка роста плода.

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The authors declare that there are no conflicts of interest present.