akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2020.14.1.69-79akusherstvo-626Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРCombined hormonal contraceptives as a risk factor for cerebrovascular accidentКомбинированные гормональные контрацептивы как фактор риска нарушений мозгового кровообращенияhttps://orcid.org/0000-0003-0590-8483НовосартянМ. Г.NovosartyanM. G.

Новосартян Маргарита Геннадиевна - акушер-гинеколог, аспирант кафедры акушерства, гинекологии и перинатологии.

Margarita G. Novosartyan - MD, Obstetrician-Gynecologist, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatology.

4 Mitrofana Sedina St, Krasnodar 350063

https://orcid.org/0000-0002-4564-8439СамбуроваН. В.SamburovaN. V.

Самбурова Наталья Викторовна - кандидат медицинских наук, доцент кафедры патофизиологии Института клинической медицины.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Natalia V. Samburova - MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Clinical Medicine.

8 bild. 2, Trubetskaya St., Moscow 119991

nsamburova@bk.ruhttps://orcid.org/0000-0003-1359-4859АничковаЕ. В.AnichkovaE. V.

Аничкова Елизавета Владимировна - студент 4-го курса медицинской школы Медицина будущего.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Elizaveta V. Anichkova - 4th year student, Medical school Medicine of the Future.

8 bild. 2, Trubetskaya St., Moscow 119991

https://orcid.org/0000-0001-6451-5861БаяндурянЭ. А.BayanduryanE. A.

Баяндурян Эммануелла Ашотовна - акушер-гинеколог, аспирант кафедры акушерства, гинекологии и перинатологии.

Emmanuella A. Bayanduryan - MD, Obstetrician-Gynecologist, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatology.

4 Mitrofana Sedina St, Krasnodar 350063

https://orcid.org/0000-0002-6524-3965АндрееваМ. Д.AndreevaM. D.

Андреева Маргарита Дарчоевна - доктор медицинских наук, профессор кафедры акушерства, гинекологии и перинаталогии.

Margarita D. Andreeva - MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatology.

4 Mitrofana Sedina St, Krasnodar 350063

https://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна - доктор медицинских наук, профессор, профессор кафедры акушерства и гинекологии Клинического института детского здоровья имени Н.Ф. Филатова, Scopus Author ID: 6506003478, Researcher ID: F-8409-2017.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Victoria O. Bitsadze - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Institute of Children’s Health, Scopus Author ID: 6506003478, Researcher ID: F-8409-2017.

ФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKuban State Medical University, Health Ministry of Russian FederationRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени ИМ. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian Federation2020030420201416979Copyright © Novosartyan M.G., Samburova N.V., Anichkova E.V., Bayanduryan E.A., Andreeva M.D., Bitsadze V.O., 20202020Новосартян М.Г., Самбурова Н.В., Аничкова Е.В., Баяндурян Э.А., Андреева М.Д., Бицадзе В.О.Novosartyan M.G., Samburova N.V., Anichkova E.V., Bayanduryan E.A., Andreeva M.D., Bitsadze V.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/626

Hormonal contraceptives are effective in preventing an unwanted pregnancy, but have side effects; among them stroke occupies an important place. The development of this serious disease may be associated with the hormonal drug components, but heavily dependent on additional risk factors for vascular and thrombotic complications such as smoking, arterial hypertension, genetically determined and acquired predisposition to thrombotic complications. This review presents an analysis of the most important risk factors for stroke such as genetic predisposition, hyperhomocysteinemia, thrombophilias in women using combined oral contraceptives.

Гормональные контрацептивы обеспечивают эффективную профилактику нежелательной беременности, однако имеют побочные эффекты, среди которых важное место занимает инсульт. Развитие этого тяжелого осложнения может быть связано с гормональными компонентами препарата, но в значительной мере зависит от присутствия дополнительных факторов риска сосудистых и тромботических осложнений, включающих курение, артериальную гипертензию, генетически детерминированную и приобретенную предрасположенность к тромботическим осложнениям. В настоящем обзоре представлен анализ наиболее значимых факторов риска развития инсульта у женщин на фоне применения комбинированных оральных контрацептивов, в том числе скрытых, таких как генетическая предрасположенность, гипергомоцистеине-мия, тромбофилии.

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The authors declare that there are no conflicts of interest present.