<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-60</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ОRIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>PATHOGENETIC ROLE OF THROMBOPHILIA IN PREECLAMPSIA DEVELOPMENT</article-title><trans-title-group xml:lang="ru"><trans-title>ПАТОГЕНЕТИЧЕСКАЯ РОЛЬ ТРОМБОФИЛИИ В РАЗВИТИИ ТЯЖЕЛЫХ ФОРМ ГЕСТОЗА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Атабаева</surname><given-names>Х. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Atabaeva</surname><given-names>Kh. L.</given-names></name></name-alternatives><email xlink:type="simple">gemostasis@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>07</day><month>06</month><year>2016</year></pub-date><volume>8</volume><issue>1</issue><fpage>34</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Atabaeva K.L., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Атабаева Х.Л.</copyright-holder><copyright-holder xml:lang="en">Atabaeva K.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/60">https://www.gynecology.su/jour/article/view/60</self-uri><abstract><p>The article describes the examination data of pregnant women with severe preeclampsia, which were analyzed for the presence of genetic thrombophilia. Reviewed approaches to prevention of obstetrics complication and antithrombotic prophylaxis with LMWH.</p></abstract><trans-abstract xml:lang="ru"><p>В статье изложены материалы обследования беременных с тяжелыми формами гестоза, у которых проводился анализ на наличие генетических форм тромбофилии. Дается научное обоснование необходимости противотромботической профилактики низкомолекулярными гепаринами.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>РОМБОФИЛИЯ</kwd><kwd>ПАТОГЕНЕЗ ТРОМБОТИЧЕСКИХ ОСЛОЖНЕНИЙ</kwd><kwd>ПРОФИЛАКТИКА ТРОМБОЗОВ</kwd><kwd>ГЕСТОЗ</kwd><kwd>ОСЛОЖНЕННАЯ БЕРЕМЕННОСТЬ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombophilia</kwd><kwd>pathogenesis of thrombotic complications</kwd><kwd>thrombosis prevention</kwd><kwd>preeclampsia</kwd><kwd>complicated pregnancy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Абаева И.Ш. Клиническое значение контроля за маркерами воспаления у беременных с синдромом потери плода и тромбофилией. Автореферат дис. канд. мед. наук. М. 2011; 23 с.</mixed-citation><mixed-citation xml:lang="en">Abaeva I.Sh. Klinicheskoe znachenie kontrolja za markerami vospalenija u beremennyh s sindromom poteri ploda i trombofiliej. Avtoreferat dis. kand. med. nauk. M. 2011; 23 s.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бицадзе В.О. Патогенез, принципы диагностики и профилактики осложнений беременности, обусловленных тромбофилией. Дисс. …докт. мед. наук. М., 2004.</mixed-citation><mixed-citation xml:lang="en">Bicadze V.O. Patogenez, principy diagnostiki i profilaktiki oslozhnenij beremennosti, obuslovlennyh trombofiliej. Diss. …dokt. med. nauk. M., 2004.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Бицадзе В.О, Макацария А.Д., Хизроева Д.Х. и др. Тромбофилия как важнейшее звено патогенеза осложнений беременности. Практическая медицина. 2012; 5: 22-29.</mixed-citation><mixed-citation xml:lang="en">Bicadze V.O, Makacarija A.D., Hizroeva D.H. i dr. Trombofilija kak vazhnejshee zveno patogeneza oslozhnenij beremennosti. Prakticheskaja medicina. 2012; 5: 22-29.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гадаева З.К. Частота и спектр полиморфизмов провоспалительных цитокинов и тромбофилии у беременных с метаболическим синдромом и гестозом. Материалы X юбилейного Всероссийского научного форума Мать и Дитя. М. 2009; 42 с.</mixed-citation><mixed-citation xml:lang="en">Gadaeva Z.K. Chastota i spektr polimorfizmov provospalitel'nyh citokinov i trombofilii u beremennyh s metabolicheskim sindromom i gestozom. Materialy X jubilejnogo Vserossijskogo nauchnogo foruma Mat' i Ditja. M. 2009; 42 s.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дубоссарская З.М., Дука Ю.М. Место тромбофилии в структуре синдрома потери плода. Таврический медико-биологический вестник. 2011; 14 (3; 1); 75-77.</mixed-citation><mixed-citation xml:lang="en">Dubossarskaja Z.M., Duka Ju.M. Mesto trombofilii v strukture sindroma poteri ploda. Tavricheskij mediko-biologicheskij vestnik. 2011; 14 (3; 1); 75-77.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Макацария А.Д., Бицадзе В.О. Тромбофилии и противотромботическая терапия в акушерской практике. М. 2003; 904 с.</mixed-citation><mixed-citation xml:lang="en">Makacarija A.D., Bicadze V.O. Trombofilii i protivotromboticheskaja terapija v akusherskoj praktike. M. 2003; 904 s.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bick R.L. Recurrent miscarriage syndrome due to blood coagulation protein/platelet defects: prevalence, treatment and outcome results. DRW Metroplex Recurrent Miscarriage Syndrome Cooperative Group. Clin. Appl. Thromb. Hemost. 2000 Jul; 6 (3): 115-25.</mixed-citation><mixed-citation xml:lang="en">Bick R.L. Recurrent miscarriage syndrome due to blood coagulation protein/platelet defects: prevalence, treatment and outcome results. DRW Metroplex Recurrent Miscarriage Syndrome Cooperative Group. Clin. Appl. Thromb. Hemost. 2000 Jul; 6 (3): 115-25.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Brenner B. Thrombophilia and pregnancy. Clin. Adv. Hematol. Oncol. 2003 Jun; 1 (6): 351-5.</mixed-citation><mixed-citation xml:lang="en">Brenner B. Thrombophilia and pregnancy. Clin. Adv. Hematol. Oncol. 2003 Jun; 1 (6): 351-5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Goodlin R. С Preeclampsia as the great impostor. Amer. J. Obstet. Gynec. 1991; 164: 1577-81.</mixed-citation><mixed-citation xml:lang="en">Goodlin R. С Preeclampsia as the great impostor. Amer. J. Obstet. Gynec. 1991; 164: 1577-81.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Karpman D., Tati R. Complement activation in thrombotic microangiopathy. Hamostaseologie. 2013 May 29; 33 (2): 96-104.</mixed-citation><mixed-citation xml:lang="en">Karpman D., Tati R. Complement activation in thrombotic microangiopathy. Hamostaseologie. 2013 May 29; 33 (2): 96-104.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mazhar S.B., Emanuel A. Haematological defects in recurrent pregnancy loss. Haematology Updates. 2011: 56-60.</mixed-citation><mixed-citation xml:lang="en">Mazhar S.B., Emanuel A. Haematological defects in recurrent pregnancy loss. Haematology Updates. 2011: 56-60.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">McCrae K.R., Cines D.B.Thrombotic microangiopathy during pregnancy. Seminhematol. 1997; 34 (2): 148-58.</mixed-citation><mixed-citation xml:lang="en">McCrae K.R., Cines D.B.Thrombotic microangiopathy during pregnancy. Seminhematol. 1997; 34 (2): 148-58.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
