akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-59Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИTHE ROLE OF CIRCULATING ANTIPHOSPHOLIPID ANTIBODIES IN THE FETAL LOSS SYNDROME DEVELOPMENTРОЛЬ ЦИРКУЛИРУЮЩИХ АНТИФОСФОЛИПИДНЫХ АНТИТЕЛ В РАЗВИТИИ СИНДРОМА ПОТЕРИ ПЛОДАСелхаджиеваМ. С.SelkhadzhievaM. S.gemostasis@mail.ruГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, МоскваРоссияThe State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian FederationRussian Federation201407062016813133Copyright © Selkhadzhieva M.S., 20162016Селхаджиева М.С.Selkhadzhieva M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/59

The article describes the examination data of pregnant women with fetal loss syndrome in anamnesis which were analyzed for the circulated antiphospholipid antibodies. Reviewed approaches to prevention of obstetrics complication and antithrombotic prophylaxis with LMWH.

В статье изложены материалы обследования беременных с синдромом потери плода в анамнезе, у которых проводился анализ циркулирующих антифосфолипидных антител. Дается научное обоснование необходимости противотромботической профилактики низкомолекулярными гепаринами.

ТРОМБОФИЛИЯСИНДРОМ ПОТЕРИ ПЛОДААНТИФОСФОЛИПИДНЫЙ СИНДРОМПРОФИЛАКТИКА ТРОМБОЗОВГЕСТОЗОСЛОЖНЕННАЯ БЕРЕМЕННОСТЬthrombophiliafetal loss syndromeantiphospholipid syndromethrombosis preventionpreeclampsiacomplicated pregnancyReferencesБицадзе В.О. Патогенез, принципы диагностики и профилактики осложнений беременности, обусловленных тромбофилией. Дисс. …докт. мед. наук. М. 2004; 271 с.Bicadze V.O. Patogenez, principy diagnostiki i profilaktiki oslozhnenij beremennosti, obuslovlennyh trombofiliej. Diss. …dokt. med. nauk. M. 2004; 271 s.Громыко Г.Л. Роль антифосфолипидного синдрома в развитии акушерских осложнений. Проблемы репродукции. 1997; 4: 13-18.Gromyko G.L. Rol' antifosfolipidnogo sindroma v razvitii akusherskih oslozhnenij. Problemy reprodukcii. 1997; 4: 13-18.Макацария А.Д. Антифосфолипидный синдром М. 2000; 373 с.Makacarija A.D. Antifosfolipidnyj sindrom M. 2000; 373 s.Макацария А.Д., Бицадзе В.О. Тромбофилии и противотромботическая терапия в акушерской практике. М. 2003; 904 с.Makacarija A.D., Bicadze V.O. Trombofilii i protivotromboticheskaja terapija v akusherskoj praktike. M. 2003; 904 s.Матвеева Т.Е. Вопросы патогенеза и профилактики синдрома потери плода у беременных с тромбофилией. Дисс. ...канд. мед. наук. М. 2002; 131 с.Matveeva T.E. Voprosy patogeneza i profilaktiki sindroma poteri ploda u beremennyh s trombofiliej. Diss. ...kand. med. nauk. M. 2002; 131 s.Сухих Г.Л., Пономарева И.В., Городничева Ж.А., Ванько Л.В. Спектр антифосфолипидных антител у беременных с гестозом. Акушерство и гинекология. 1998; 5: 22-26.Suhih G.L., Ponomareva I.V., Gorodnicheva Zh.A., Van'ko L.V. Spektr antifosfolipidnyh antitel u beremennyh s gestozom. Akusherstvo i ginekologija. 1998; 5: 22-26.Amergual O., Atsumi T., Khamashta M.A, Tinohones F., Hughes G.R.V. Autoantibodies against oxidazed low density lipoprotein in antiphospholipid syndrome. Br. J. Rheumatol. 1997; 36: 964-968.Amergual O., Atsumi T., Khamashta M.A, Tinohones F., Hughes G.R.V. Autoantibodies against oxidazed low density lipoprotein in antiphospholipid syndrome. Br. J. Rheumatol. 1997; 36: 964-968.Backos M., Rai R., Baxter N., Chilcott I.T, Cohen H., Regan L. Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low-dose aspirin and heparin. Br. Obstet Gynaecol. 1999; 106: 102-7.Backos M., Rai R., Baxter N., Chilcott I.T, Cohen H., Regan L. Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low-dose aspirin and heparin. Br. Obstet Gynaecol. 1999; 106: 102-7.Bates S.M., Greer I.A., Pabinger I., Sofaer S., Hirsh J. Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy: Evidence-Based Clinical Practice Guidelines American College of Chest Physicians (8th Edition). Chest. 2008; 133; 844-886.Bates S.M., Greer I.A., Pabinger I., Sofaer S., Hirsh J. Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy: Evidence-Based Clinical Practice Guidelines American College of Chest Physicians (8th Edition). Chest. 2008; 133; 844-886.Botet F., Romera G., Montagut P., Figueras J., Carmona J., Balasch J. Neonatal outcome in women treated for the antiphospholipid syndrome during pregnancy. J. Perinat. Med. 1997; 25: 192-196.Botet F., Romera G., Montagut P., Figueras J., Carmona J., Balasch J. Neonatal outcome in women treated for the antiphospholipid syndrome during pregnancy. J. Perinat. Med. 1997; 25: 192-196.Cowchock S. Antibodies and pregnancy loss. The New Eng. Journal of Medicine. July 17, 1997; 197-198.Cowchock S. Antibodies and pregnancy loss. The New Eng. Journal of Medicine. July 17, 1997; 197-198.de Laat B., Mertens K., de Groot Ph. Mechanisms of disease: antiphospholipid antibodies -from clinical association to pathologic mechanism nature clinical practice / B. de Laat, K. Mertens, Ph. de Groot. Rheumatology. 2008; 4 (4): 192-199.de Laat B., Mertens K., de Groot Ph. Mechanisms of disease: antiphospholipid antibodies -from clinical association to pathologic mechanism nature clinical practice / B. de Laat, K. Mertens, Ph. de Groot. Rheumatology. 2008; 4 (4): 192-199.Empson M., Lassere M., Craig J.C., Scott J.R. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet. Gynecol. 2002; 99:135-44.Empson M., Lassere M., Craig J.C., Scott J.R. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet. Gynecol. 2002; 99:135-44.Farquharson R.G., Quenby S., Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet. Gynecol. 2002; l00: 408-13.Farquharson R.G., Quenby S., Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet. Gynecol. 2002; l00: 408-13.Gandra M.J., Fraga M., Saraiva J.P., Andrade J. Anticardiolipin antibodies and high risk pregnancy. 16th Congress on thromb and haemost. Porto. 2000; abstr. p. 160.Gandra M.J., Fraga M., Saraiva J.P., Andrade J. Anticardiolipin antibodies and high risk pregnancy. 16th Congress on thromb and haemost. Porto. 2000; abstr. p. 160.Genievskaya M., Makatsaria A. Low molecular weight heparin (Fraxiparine) as long-term single agent therapy in pregnant with antiphospholipid syndrome. 16th Congress oh thrombosis and haemostasis. Porto. 2000, abstr. p. 161.Genievskaya M., Makatsaria A. Low molecular weight heparin (Fraxiparine) as long-term single agent therapy in pregnant with antiphospholipid syndrome. 16th Congress oh thrombosis and haemostasis. Porto. 2000, abstr. p. 161.Granger K.A., Farquharson R.G., Obstetric outcome in antiphosholipid syndrome. Lupus. 1997; 6: 509-513.Granger K.A., Farquharson R.G., Obstetric outcome in antiphosholipid syndrome. Lupus. 1997; 6: 509-513.Honig A. Pregnancy-triggered antiphospholipid syndrome in a patient with multiple late miscarriages / A. Honig et al. Hum. Reprod. 2010; 25 (11): 2753-2754.Honig A. Pregnancy-triggered antiphospholipid syndrome in a patient with multiple late miscarriages / A. Honig et al. Hum. Reprod. 2010; 25 (11): 2753-2754.Levy R.A., Avvad E., Olivera J., Porto L.C. Placental pathology in antiphospholipid syndrome. Lupus. 1998; 7 (2): 81-85.Levy R.A., Avvad E., Olivera J., Porto L.C. Placental pathology in antiphospholipid syndrome. Lupus. 1998; 7 (2): 81-85.Lyden T.W., Vogt E., Ng A.K., Johnson P.M., Rote N.S. Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. Reprod Immunol. 1992; 22: 1-14.Lyden T.W., Vogt E., Ng A.K., Johnson P.M., Rote N.S. Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. Reprod Immunol. 1992; 22: 1-14.Zeev Blumenfeld, Benjamin Brenner. Thrombophilia-associated pregnancy wastage. Fertility and sterility. Nov. 1999; 72 (5): 765-774.Zeev Blumenfeld, Benjamin Brenner. Thrombophilia-associated pregnancy wastage. Fertility and sterility. Nov. 1999; 72 (5): 765-774.

The authors declare that there are no conflicts of interest present.