akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLCakusherstvo-58Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИASSISTED REPRODUCTIVE TECHNOLOGY AND ANTIPHOSPHOLIPID SYNDROMEВСПОМОГАТЕЛЬНЫЕ РЕПРОДУКТИВНЫЕ ТЕХНОЛОГИИ И АНТИФОСФОЛИПИДНЫЙ СИНДРОМХизроеваД. Х.KhizroevaJ. Kh.gemostasis@mail.ruМашковаТ. М.MashkovaT. M.ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова» Минздрава РФ, МоскваРоссияChair of Obstetrics and Gynaecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical UniversityRussian Federation201407062016812630Copyright © Khizroeva J.K., Mashkova T.M., 20162016Хизроева Д.Х., Машкова Т.М.Khizroeva J.K., Mashkova T.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/58

The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet phase of hemostasis, which is associated with numerous obstetrical complications andinfertility. The question is, what is the frequency of circulating APA in women who underwent IVF failure and whether there is a relationship between the presence of APA and poor reproduction outcome? This study aimed at elucidating the effect of the presence of APA on the outcomes of assisted reproductive technology (ART). A total of 267 women diagnosed with infertility and planning to get pregnant using the assisted reproductive technology (ART) have been examined. The results of examination demonstrated a high prevalence of circulating APA in a group of women who underwent IVF failure. High titers of APA were found in 42.1% of female patients who had undergone IVF failure. The fraction of women in whom fertility treatment using ART succeeded was 19.1%.

Антифосфолипидные антитела (АФА) оказывают многогранное влияние на систему гемостаза, повреждая все его защитные звенья: эндотелиальный барьер, функцию естественных антикоагулянтов, эндогенный фибринолиз, активируя тромбоцитарное звено гемостаза и ассоциируются со множеством акушерских осложнений и бесплодием. Но какова частота циркуляции АФА у женщин с неудачами ЭКО и связаны ли АФА с худшим репродуктивным исходом? Целью данной работы было изучение влияния АФА на исходы вспомогательных репродуктивных технологий. Было обследовано 267 женщин с бесплодием, планировавших наступление беременности с помощью вспомогательных репродуктивных технологий (ВРТ). Результаты обследования продемонстрировали большую частоту циркуляции АФА в группе женщин с неудачами ЭКО. Высокие титры АФА наблюдались у 42,1% пациентов с неудачами ЭКО. Среди женщин, беременность у которых наступила с помощью ВРТ, доля АФА составила 19,1%.

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The authors declare that there are no conflicts of interest present.