akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2019.13.2.119-131akusherstvo-562Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫSystematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive ageСистематический анализ исследований по D-маннозе и перспективы ее применения при рецидивирующих инфекциях мочеполовых путей у женщин репродуктивного возрастаhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – д.м.н., профессор, ведущий научный сотрудник, научный руководитель;

ведущий научный сотрудник 

Scopus Author ID: 7003589812 

Author ID: 94901 

РИНЦ SPIN-код: 6317-9833 

WOS ID: J-4946-2017

Olga A. Gromova – MD, PhD, Professor, Leading Researcher, Scientific Director

Leading Researcher

Scopus Author ID: 7003589812

Author ID: 94901

РИНЦ SPIN-код: 6317-9833

WOS ID: J-4946-2017

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич – к.х.н., старший научный сотрудник 

старший научный сотрудник 

Author ID: 54104 

Scopus Author ID: 7003300274 

РИНЦ SPIN-код: 1375-1114 

WOS ID: C-7683-2018

Ivan Yu. Torshin – PhD (Chemistry), Senior Researcher

Senior Researcher

Author ID: 54104 

Scopus Author ID: 7003300274 

РИНЦ SPIN-код: 1375-1114 

WOS ID: C-7683-2018

ТетруашвилиН. К.TetruashviliN. K.

Тетруашвили Нана Картлосовна – д.м.н., профессор, зав. 2-м акушерским отделением патологии беременности 

Nana K. Tetruashvili – MD, PhD, Professor, Head of Obstetric Department of Pregnancy Pathology № 2

ФГБУ «Федеральный исследовательский центр "Информатика и управление" Российской академии наук»; Центр хранения и анализа больших данных, ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияFederal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State UniversityRussian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Health Ministry of Russian FederationRussian Federation201904072019132119131Copyright © Gromova O.A., Torshin I.Y., Tetruashvili N.K., 20192019Громова О.А., Торшин И.Ю., Тетруашвили Н.К.Gromova O.A., Torshin I.Y., Tetruashvili N.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/562

Cystitis and other urinary tract infections (UTIs) in women of reproductive age can lead to infertility, significantly complicate the course of pregnancy, and cause numerous fetal abnormalities. Antibiotic therapy during pregnancy is an extreme measure since it is associated with a high risk of fetal malformations. The use of D-mannose is an effective and safe treatment for cystitis and other UTIs, especially during pregnancy. The present systematic analysis of 32111 studies indicates a significance of D-mannose for glycosylation of human proteins and for functioning of the immune, cardiovascular, urinary and other systems. By blocking the interaction between bacterial fimbriae and the endothelium, D-mannose prevents the adsorption of bacteria (uropathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Shigella, leishmania, mycobacteria, etc.) to the tissue surface, thus helping prevent recurrent UTIs. Clinical studies have confirmed both high efficacy and safety of using D-mannose and the synergistic substances (such as cranberry anthocyanins) for the treatment of cystitis and other UTIs.

Цистит и другие инфекции мочеполовых путей (ИМП) у женщин репродуктивного возраста могут приводить к бесплодию, существенно осложняют течение беременности и вызывают многочисленные патологии плода. Антибиотикотерапия во время беременности – крайняя мера, поскольку сопряжена с высоким риском пороков развития плода. Эффективным и безопасным направлением терапии цистита и других ИМП, особенно во время беременности, является использование D-маннозы. Систематический анализ 32111 исследований указал на важность D-маннозы для гликозилирования белков протеома человека, поддержки функций иммунной, сердечно-сосудистой, мочевыводящей и других систем. Блокируя взаимодействие бактериальных фимбрий с эндотелием, D-манноза предотвращает адсорбцию различных бактерий (уропатогенных штаммов Escherichia coli, Pseudomonas aeruginosa, шигелл, лейшманий, микобактерий и др.) на поверхности тканей, что способствует профилактике рецидивирующих ИМП. Клинические исследования подтвердили высокую эффективность и безопасность использования D-маннозы и веществ-синергистов (антоцианины клюквы и др.) для терапии цистита и других ИМП.

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The authors declare that there are no conflicts of interest present.