akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2018.12.4.015-020akusherstvo-530Research ArticleОRIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИThe relationships between pregnancy-associated protein A levels, placental localization and fetal birth weightВзаимосвязь между содержанием ассоциированного с беременностью протеина А, локализацией плаценты и весом плода при рожденииГюлерА. Е.GülerA. E.

врач, отделение гинекологии и акушерства

MD, Gynecology and Obstetrics Department

https://orcid.org/0000-0001-8232-4719АтасеверМ.AtaseverM.

доцент медицинского факультета, отделение акушерства и гинекологии

Associate Professor, Faculty of Medicine, Department of Obstetrics and Gynecology

ФиданУ.FidanU.

доцент медицинского факультета Гюльхане, отделение акушерства и гинекологии

Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology

АртюркЕ.ArtürkE.

врач

MD

КинчиМ. Ф.KinciM. F.

врач, медицинский факультет Гюльхане, отделение акушерства и гинекологии

MD, Gülhane Medical Faculty, Department of Obstetrics and Gynecology

https://orcid.org/0000-0003-4461-9174БодурС.BodurS.

врач, доцент медицинского факультета Гюльхане, отделение акушерства и гинекологии

MD, Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology

drserkanbodur@gmail.comГоспиталь Локман, ФетхиеТурцияLokman Hospital, Fethiye, TurkeyTurkeyГиресунский университет, ГиресунТурцияGiresun University, GiresunTurkeyУниверситет медицинских наук; Турция 06010, Кечиорен-АнкараТурцияUniversity of Health Sciences; Keçiören-Ankara, 06010 TurkeyTurkeyГоспиталь гинекологии и акушерства, Шишли, СтамбулТурцияHospital Gynecology and Obstetrics, Sisli, İstanbulTurkey2018260220191241520Copyright © Güler A.E., Atasever M., Fidan U., Artürk E., Kinci M.F., Bodur S., 20192019Гюлер А.Е., Атасевер М., Фидан У., Артюрк Е., Кинчи М.Ф., Бодур С.Güler A.E., Atasever M., Fidan U., Artürk E., Kinci M.F., Bodur S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/530

Aim. This study was designed to determine the relationship between pregnancy-associated protein A (PAPP-A), placenta localization and fetal birth weight (FBW). Materials and methods. First trimester PAPP-A levels, second trimester placental localization and birth weights of 1145 infants were obtained through a retrospective review of the patient follow up charts in Koru Hospital. Serum PAPP-A levels were recorded as the multiple of median (MоM) values, the FBW values of infants were recorded in grams, and the placental localization was recorded under seven different pre-defined categories: 1. placenta anterior; 2. placenta posterior; 3. placenta fundal; 4. placenta fundal-anterior; 5. placenta fundal-posterior; 6. placenta lateral-right; 7. placenta lateral-left. The data were analyzed using the Statistical Package for Social Sciences (SPSS) program (SPSS Inc., Chicago, IL, USA). Results. There was no significant difference between the FBW and PAPP-A levels. The comparison of seven placental localizations shows that the anterior and posterior localizations have an impact on FBW of the infants. Conclusion. The FBW was highest in the cases where the placenta was located in the corpus uteri. We believe this finding is consistent with the fact that the corpus uteri receives the largest blood supply.

Цель исследования: выяснить взаимосвязь между ассоциированным с беременностью протеином A (PAPP-A), локализацией плаценты и весом плода при рождении. Материалы и методы. Значения PAPP-A в I триместре, локализацию плаценты во II триместре и вес 1145 младенцев при рождении определяли посредством ретроспективного анализа карт наблюдения пациенток в госпитале Кору (Анкара). Уровень PAPP-A в сыворотке рассчитывали как кратное медианы (коэффициент, показывающий степень отклонения значения показателя от среднего значения), вес плода измеряли в граммах, а локализацию плаценты определяли по 7 градациям: 1. плацента по передней стенке матки; 2. плацента по задней стенке; 3. плацента в дне матки; 4. плацента в нижнем переднем положении; 5. плацента в нижнем заднем положении; 6. плацента в правом боковом положении; 7. плацента в левом боковом положении. Данные были проанализированы с использованием программы Statistical Package for Social Sciences (SPSS Inc., Чикаго, Иллинойс, США). Результаты. Достоверных различий между значениями PAPP-A и весом плода при рождении выявлено не было. Сравнение 7 локализаций плаценты показало, что передняя и задняя локализация оказывают влияние на вес младенцев при рождении. Заключение. Установлено, что вес плода при рождении является наиболее высоким, когда плацента расположена в теле матки. Несмотря на то, что объяснение этого наблюдения не входило в задачи нашего исследования, мы полагаем, что данный результат отражает обильное кровоснабжение тела матки.

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The authors declare that there are no conflicts of interest present.