akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2018.12.2.055-061akusherstvo-495Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫA novel approach to the differential prognosis of early and late preeclampsiaНовые возможности дифференциального прогнозирования ранней и поздней преэклампсииСтрижаковА. Н.StrizhakovA. N.

Стрижаков Александр Николаевич – академик РАН, доктор медицинских наук, профессор, заведующий кафедрой акушерства, гинекологии и перинатологии лечебного факультета

119991, Москва, ул. Трубецкая 8, стр. 2

Strizhakov Alexander Nikolaevich – Academician of RAS, MD, Professor, Head of Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8, str. 2, ul. Trubetskaya, Moscow, 119991

ТимохинаЕ. В.TimokhinaЕ. V.

Тимохина Елена Владимировна – доктор медицинских наук, профессор кафедры акушерства, гинекологии и перинатологии лечебного факультета

119991, Москва, ул. Трубецкая 8, стр. 2

Timokhina Elena Vladimirovna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8, str. 2, ul. Trubetskaya, Moscow, 119991

elena.timokhina@mail.ruИбрагимоваС. М.IbragimovaS. M.

Ибрагимова Сапият Магомедалиевна – аспирант кафедры акушерства, гинекологии и перинатологии лечебного факультета

119991, Москва, ул. Трубецкая 8, стр. 2

Ibragimova Sapiyat Magomedalievna – Postgraduate Student, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine

8, str. 2, ul. Trubetskaya, Moscow, 119991

БелоусоваВ. С.BelousovaV. S.

Белоусова Вера Сергеевна – доцент кафедры акушерства, гинекологии и перинатологии лечебного факультета

119991, Москва, ул. Трубецкая 8, стр. 2

Belousova Vera Sergeevna – Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Faculty of General and Preventive Medicine

8, str. 2, ul. Trubetskaya, Moscow, 119991

МартиросянЯ. О.MartirosyanYa. O.

Мартиросян Яна Ованнесовна – студент

119991, Москва, ул. Трубецкая 8, стр. 2

Martirosyan Yana Ovannesovna – Medical Student

8, str. 2, ul. Trubetskaya, Moscow, 119991

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationRussian Federation2018270820181225561Copyright © Strizhakov A.N., Timokhina Е.V., Ibragimova S.M., Belousova V.S., Martirosyan Y.O., 20182018Стрижаков А.Н., Тимохина Е.В., Ибрагимова С.М., Белоусова В.С., Мартиросян Я.О.Strizhakov A.N., Timokhina Е.V., Ibragimova S.M., Belousova V.S., Martirosyan Y.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/495

In the present review, a new approach to studying the pathogenesis and predicting the development of preeclampsia (PE) – namely, the determination of matrix metalloproteinases (MMPs) – is discussed. Currently, the major cause of PE is thought to be an incomplete remodeling of spiral arteries because of an insufficient number of invading cytotrophoblasts or the absence/inactivation of crucial lysing enzymes, i.e. matrix metalloproteinases. The role of MMP-1, MМP-2, MМP-3, MМP-7, MМP-9 in the placenta formation, the development of oxidative stress and endothelial dysfunction is described. We propose that in the future, the MMPs may be used for differentially predicting early and late PE.

В представленном обзоре обсуждается новый подход в изучении патогенеза и прогнозирования преэклампсии (ПЭ) – роль матриксных металлопротеиназ (ММП). В настоящее время ведущей причиной ПЭ рассматривается неполная перестройка спиральных артерий вследствие недостаточного количества инвазирующих клеток цитотрофобласта или отсутствие/инактивация необходимых лизирующих ферментов – ММП. Рассмотрена роль ММП-1, ММП-2, ММП-3, ММП-7, ММП-9 в формировании плаценты, развитии оксидативного стресса, эндотелиальной дисфункции. Указано, что ММП в будущем могут быть использованы в качестве маркеров дифференциального прогнозирования ранней и поздней ПЭ.

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The authors declare that there are no conflicts of interest present.