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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347.2018.12.1.093-098</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-475</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЙ ОБЗОР</subject></subj-group></article-categories><title-group><article-title>GESTATIONAL TROPHOBLASTIC DISEASE: CLASSIFICATION, EPIDEMIOLOGY AND PATHOGENESIS</article-title><trans-title-group xml:lang="ru"><trans-title>ГЕСТАЦИОННАЯ ТРОФОБЛАСТИЧЕСКАЯ БОЛЕЗНЬ: ВОПРОСЫ КЛАССИФИКАЦИИ, ЭПИДЕМИОЛОГИИ И ЭТИОПАТОГЕНЕЗА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солопова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Solopova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солопова Антонина Григорьевна – доктор медицинских наук, профессор кафедры акушерства и гинекологии медико-профилактического факультета.</p><p>109004, Москва, ул. Земляной Вал, 62, стр. 1</p></bio><bio xml:lang="en"><p>Solopova Antonina Grigorievna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.</p><p>62, str. 1, ul. Zemlyanoi Val, Moscow, 109004</p></bio><email xlink:type="simple">antoninasolopova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макацария</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Makatsariya</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макацария Александр Давидович – доктор медицинских наук, член-корреспондент РАН, профессор, зав. кафедрой акушерства и гинекологии медико-профилактического факультета.</p><p>109004, Москва, ул. Земляной Вал, 62, стр. 1, +7(495)7885840</p></bio><bio xml:lang="en"><p>Makatsariya Alexander Davidovich – MD, Corresponding Member of RAS, Professor, Head of Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.</p><p>62, str. 1, ul. Zemlyanoi Val, Moscow, 109004</p></bio><email xlink:type="simple">gemostasis@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Елена Сергеевна – кандидат медицинских наук, доцент кафедры акушерства и гинекологии медико-профилактического факультета.</p><p>109004, Москва, ул. Земляной Вал, 62, стр. 1, +7(910)412-06-43</p></bio><bio xml:lang="en"><p>Egorova Elena Sergeevna – PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.</p><p>62, str. 1, ul. Zemlyanoi Val, Moscow, 109004, +7(910)4120643</p></bio><email xlink:type="simple">eesdoctor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Москвичёва</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Moskvichyova</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москвичёва В.С. – студентка 6-го курса педиатрического факультета.</p><p>109004, Москва, ул. Земляной Вал, 62, стр. 1</p></bio><bio xml:lang="en"><p>Moskvichyova V.S. – 6th year Medical Student, Faculty of Pediatrics.</p><p>62, str. 1, ul. Zemlyanoi Val, Moscow, 109004, +7(925)1290922</p></bio><email xlink:type="simple">moskvicheva_viktoria@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митрюк</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitryuk</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Митрюк Диана Викторовна – ассистент кафедры акушерства и гинекологии.</p><p>Кишинев, бул. Штефан чел Маре, 165</p></bio><bio xml:lang="en"><p>Mitryuk Diana Viktorovna – Аssistant, Department of Obstetrics and Gynecology.</p><p>165, bul. Shtefan chel Mare, Kishinev</p></bio><email xlink:type="simple">diana.mitriuc@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет  имени И.М. Сеченова» Министерства здравоохранения Российской Федерации  (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University,   Health Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Государственный медицинский и фармацевтический университет  имени Николае Тестемицану Республики Молдова</institution><country>Молдова</country></aff><aff xml:lang="en"><institution>State Medical and Pharmaceutical University «Nicolae Testemitanu» Republic of Moldova</institution><country>Moldova, Republic of</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>26</day><month>05</month><year>2018</year></pub-date><volume>12</volume><issue>1</issue><fpage>93</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Solopova A.G., Makatsariya A.D., Egorova E.S., Moskvichyova V.S., Mitryuk D.V., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Солопова А.Г., Макацария А.Д., Егорова Е.С., Москвичёва В.С., Митрюк Д.В.</copyright-holder><copyright-holder xml:lang="en">Solopova A.G., Makatsariya A.D., Egorova E.S., Moskvichyova V.S., Mitryuk D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/475">https://www.gynecology.su/jour/article/view/475</self-uri><abstract><p>Gestational trophoblastic disease (GTD) is a cumulative name of the diseases that occur in pregnant women as a result of abnormal trophoblast proliferation. It includes benign (full or partial hydatidiform mole) and malignant (so-called gestational trophoblastic neoplasias) diseases. Statistically, the incidence of hydatidiform mole varies from region to region. That may be due to either the ethnic factors or related to a specific diet, the quality of diagnosis, representatives of the statistical data and the lack of a uniform protocol of data registration.</p></abstract><trans-abstract xml:lang="ru"><p>Гестационная трофобластическая болезнь – это группа патологий, возникающих у беременных в результате аномальной пролиферации трофобласта. Она включает доброкачественные (полный и частичный пузырный занос) и злокачественные (так называемые гестационные трофобластические неоплазии) заболевания. Статистически отмечается географическая неоднородность распространения пузырного заноса. В то время как эти данные свидетельствуют о важности этнической принадлежности, истинные причины могут иметь непосредственное отношение к диете, качеству диагностики, более или менее полному охвату населения и различиям в регистрации статистических данных.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гестационная трофобластическая болезнь</kwd><kwd>пузырный занос</kwd><kwd>хорионэпителиома</kwd><kwd>трофобластическая опухоль плацентарного ложа</kwd><kwd>эпителиоидная трофобластическая опухоль</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gestational trophoblastic disease</kwd><kwd>hydatidiform mole</kwd><kwd>chorionepithelioma</kwd><kwd>placental site trophoblastic tumor</kwd><kwd>epithelioid trophoblastic tumor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Seckl M.J., Sebire N.J., Berkowitz R.S. Gestational trophoblastic disease. 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