akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2015.10.1.038-048akusherstvo-34Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРFOLATE DEFICIENCY IN OBSTETRICS AND THE PROBLEM OF ITS CORRECTIONФОЛАТДЕФИЦИТНЫЕ СОСТОЯНИЯ В АКУШЕРСКОЙ ПРАКТИКЕ И ПРОБЛЕМА ИХ КОРРЕКЦИИБицадзеВ. О.BitsadzeV. O.

д.м.н., профессор, профессор кафедры акушерства и гинекологии медико-профилактического факультета Первого МГМУ им. И.М. Сеченова. Адрес: ул. Трубецкая, 8, стр. 2, Москва, Россия, 119048. Тел.: +7(495)7885840.

MD, Professor, Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840

gemostasis@mail.ruСамбуроваН. В.SamburovaN. V.

к.м.н., доцент кафедры патофизиологии Первого МГМУ им. И.М. Сеченова. Адрес: ул. Трубецкая, 8, стр. 2, Москва, Россия, 119048. Тел.: +7(495)7885840

Assistant professor, Department of Pathophysiology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840

gemostasis@mail.ruМакацарияН. А.MakatsariyaN. A.

к.м.н., ассистент кафедры акушерства и гинекологии медико-профилактического факультета Первого МГМУ имени И.М. Сеченова. Адрес: ул. Трубецкая, 8, стр. 2, Москва, Россия, 119048 Тел.: +7(495)7885840

Assistant of the Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: Trubetskaya str., 8, p. 2, Moscow, Russia, 119048 Тел.: +7(903)1182433

makatsariya@gmail.comМищенкоА. Л.MishchenkoA. L.

д.м.н., старший научный сотрудник НОКЦ «Клиническая гемостазиология» Первого МГМУ им. И.М. Сеченова. Адрес: ул. Трубецкая, 8, стр. 2, Москва, Россия, 119048. Тел.: +7(495)7885840

MD, research assistance of Scientific Educational Clinical Centre «Clinical Hemostasiology», First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840

gemostasis@mail.ruГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationRussian Federation2016050620161013848Copyright © Bitsadze V.O., Samburova N.V., Makatsariya N.A., Mishchenko A.L., 20162016Бицадзе В.О., Самбурова Н.В., Макацария Н.А., Мищенко А.Л.Bitsadze V.O., Samburova N.V., Makatsariya N.A., Mishchenko A.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/34

The article considers the reasons and the role of the folate deficiency in development of the complicated pregnancy and congenital malformations. The biological functions of folate in an organism are described, as well as the role of folate in an exchange of methionine and a hyperhomocysteinemia as one of the reasons of malformations and complications of pregnancy. The role of a genetic mutation of MTHFR as the hyperhomocysteinemia reasons at patients with deficiency of folate and the treatment of the state of the deficiency of folate are discussed.

В статье рассматриваются причины фолатдефицитных состояний и их роль в развитии осложненного течения беременности и врожденных пороков развития плода. Описаны биологические функции фолатов в организме, их роль в нарушении обмена метионина и гипергомоцистеинемия, как одна из причин пороков развития плода и осложнений беременности при фолатдефицитных состояниях. Обсуждается роль генетической мутации MTHFR, как причины гипергомоцистеинемии при дефиците фолатов, и принципы коррекции фолатдефицитных состояний.

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The authors declare that there are no conflicts of interest present.