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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>INFRINGEMENT OF ANGIOGENESIS AND SCLEROSIS REGULATION PROCESSES IN HYPERPLASTIC ENDOMETRIUM</article-title><trans-title-group xml:lang="ru"><trans-title>НАРУШЕНИЯ ПРОЦЕССОВ РЕГУЛЯЦИИ АНГИОГЕНЕЗА И СКЛЕРОЗИРОВАНИЯ ПРИ ГИПЕРПЛАСТИЧЕСКИХ ПРОЦЕССАХ ЭНДОМЕТРИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шешукова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheshukova</surname><given-names>N. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаров</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarov</surname><given-names>L. O.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федотова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedotova</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздравсоцразвития России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздравсоцразвития России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital #14 named after V.G. Korolenko, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГКБ № 14 им. В.Г. Короленко, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital #14 named after V.G. Korolenko, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>07</day><month>09</month><year>2016</year></pub-date><volume>6</volume><issue>3</issue><fpage>45</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Sheshukova N.A., Makarov L.O., Fedotova A.S., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Шешукова Н.А., Макаров И.О., Федотова А.С.</copyright-holder><copyright-holder xml:lang="en">Sheshukova N.A., Makarov L.O., Fedotova A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/328">https://www.gynecology.su/jour/article/view/328</self-uri><abstract><p>Pathomorphological and immunohistochemical studies of endometrium were performed. The higher proliferative activity of the VEGF and the higher production of transformation growth factor β1 (TGFβ1), fibronectin and liziloxydaza in patiens with atypical hyperplasia of endometrium and chronic endometritis testifies the presence of cellular hypoxia, disturbance of intercellular and extracellular interaction and can be considered as the negative prognostic factor.</p></abstract><trans-abstract xml:lang="ru"><p>Проведено патоморфологическое и иммуногистохимическое исследование соскобов эндометрия. Высокая пролиферативная активность сосудисто-эндотелиального фактора роста (СЭФР) и повышенная экспрессия трансформирующего фактора роста β1 (ΤΦΡβΙ), фибронектина и лизилоксидазы у пациенток с атипической гиперплазией эндометрия и при сопутствующем хроническом эндометрите свидетельствует о наличии клеточной гипоксии, нарушении межклеточного и клеточно-матриксного взаимодействия и может считаться негативным прогностическим фактором.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперпластические процессы эндометрия</kwd><kwd>хронический эндометрит</kwd><kwd>сосудис- то-эндотелиальный фактор роста</kwd><kwd>трансфор- мирующий фактор роста β1</kwd><kwd>фибронектин</kwd><kwd>лизилоксидаза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hyperplastic processes of endometrium</kwd><kwd>chronic endometritis</kwd><kwd>liziloxydaza</kwd><kwd>vascular endothelial growth factor</kwd><kwd>transformation growth factor β1</kwd><kwd>fibronectin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кузнецова И.В. 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