akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347.2015.10.1.005-010akusherstvo-31Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРMICROVESICLES AND THROMBOSIS IN OBSTETRIC-GYNECOLOGICAL COMPLICATIONSМИКРОВЕЗИКУЛЫ И ТРОМБОЗ ПРИ ОСЛОЖНЕНИЯХ В АКУШЕРСТВЕ И ГИНЕКОЛОГИИАаронА.AharonA.

PhD, руководитель лаборатории по исследованию микровезикул, отдел тромбоза и гемостаза, Отделение гематологии, Медицинский городок Рамбам. Адрес: а\я 9602, Хайфа 31096, Израиль

PhD, Head, Microvesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel. Phone: +972-54-8004600. Fax: +972 4 777 3886

a_aharon@yahoo.comБреннерБ.BrennerB.

проф., отделение гематологии и трансплантации костного мозга, Медицинский городок Рамбам,Хайфа, Израиль

MD, Professor, Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

Лаборатория по исследованию микровезикул, отделение гематологии и трансплантации костного мозга, Медицинский городок Рамбам, Хайфа, Израиль Медицинский факультет им. Брюса Раппапорта, Технион, Хайфа, ИзраильРоссияMicrovesicles Research Laboratory, Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelRussian Federation201605062016101510Copyright © Aharon A., Brenner B., 20162016Аарон А., Бреннер Б.Aharon A., Brenner B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/31

Microvesicles (MVs), including microparticles and exosomes, are secreted from a variety of cells. They are present in the blood circulation under normal physiological conditions, and their levels increase in a wide range of disease states. MVs contain proteins, growth and apoptotic factors, DNA fragments, microRNAs as well as messenger RNAs (mRNAs); therefore, they may function as regulators in cell-cell communication and mediators of cell signaling during multiple biological processes. The current review focuses on the role of MVs in healthy pregnancy and gestational vascular complications and discusses the involvement of MVs in thrombosis, hemostasis and cell function that overall reflect the placental-maternal crosstalk.

Микровезикулы (МВ), включая микрочастицы и экзосомы, секретируются из множества клеток. Они присутствуют в кровотоке при нормальных физиологических условиях и их уровни увеличиваются при многих заболеваниях. MВ содержат белки, факторы роста и апоптопические факторы, фрагменты ДНК, микроРНК, а также информационные РНК; следовательно они могут регулировать межклеточные коммуникации и являться посредниками для передачи сигналов клеток в течение разнообразных биологических процессов. Данный обзор сфокусирован на роли МВ для здоровой беременности и при гестационных сосудистых осложнениях, в нем обсуждается участие МВ в тромбозах, гемостазе и функционировании клеток, которое по сути своей отражает взаимное влияние плаценты и организма матери.

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The authors declare that there are no conflicts of interest present.