akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.768akusherstvo-2892Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРPolycystic ovary syndrome and cardiometabolic risk: current approaches to multidisciplinary prevention and follow-up careСиндром поликистозных яичников и кардиометаболический риск: современные подходы к междисциплинарной профилактике и динамическому наблюдениюhttps://orcid.org/0009-0004-2960-9490МасягутовТ. А.MasyagutovT. A.

Масягутов Тимур Азатович

450008 Уфа, ул. Ленина, д. 3

Timur A. Masyagutov

3 Lenin Str., Ufa 450008

masyagut-m@yandex.ruhttps://orcid.org/0009-0005-1408-1520ГутовМ. Р.GutovM. R.

Гутов Марат Раильевич

450008 Уфа, ул. Ленина, д. 3

Marat R. Gutov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0009-1832-6387ГаламайВ. В.GalamayV. V.

Галамай Виктория Викторовна

450008 Уфа, ул. Ленина, д. 3

Viktoriya V. Galamay

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0008-1874-8304МиндияроваД. С.MindiyarovaD. S.

Миндиярова Дарья Сергеевна

450008 Уфа, ул. Ленина, д. 3

Darya S. Mindiyarova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-1663-9106ГайнуллинУ. Р.GainullinU. R.

Гайнуллин Урал Рустамович

450008 Уфа, ул. Ленина, д. 3

Ural R. Gainullin

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-4284-0815ХашероваД. Р.KhasherovaD. R.

Хашерова Дина Рамилевна

450008 Уфа, ул. Ленина, д. 3

Dina R. Khasherova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0009-6715-637XСиразетдиноваА. В.SirazetdinovaA. V.

Сиразетдинова Алина Венеровна

450008 Уфа, ул. Ленина, д. 3

Alina V. Sirazetdinova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0005-9667-7247КучаеваД. Э.KuchaevaD. E.

Кучаева Диана Эриковна

450008 Уфа, ул. Ленина, д. 3

Diana E. Kuchaeva

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0001-2322-6905КучаеваД. Б.KuchaevaD. B.

Кучаева Диана Бикташевна

450008 Уфа, ул. Ленина, д. 3

Diana B. Kuchaeva

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0008-6696-2866ЕдренкинаА. Д.EdrenkinaA. D.

Едренкина Анна Дмитриевна

450008 Уфа, ул. Ленина, д. 3

Anna D. Edrenkina

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0008-2445-4118СаратоваА. А.SaratovaA. A.

Саратова Анастасия Алексеевна

450008 Уфа, ул. Ленина, д. 3

Anastasiia A. Saratova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0005-0266-7540ГайсинаА. Р.GaysinaA. R.

Гайсина Алия Ралифовна

450008 Уфа, ул. Ленина, д. 3

Aliya R. Gaysina

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0005-1479-5734ЛещишинаО. Ю.LeshchishinaO. Yu.

Лещишина Олеся Юрьевна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Olesya Yu. Leshchishina

29 Nakhichevansky Lane, Rostov-on-Don 344022

ФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical University, Ministry of Health of the Russian FederationRussian Federation20262807202600Online First2892Copyright © Masyagutov T.A., Gutov M.R., Galamay V.V., Mindiyarova D.S., Gainullin U.R., Khasherova D.R., Sirazetdinova A.V., Kuchaeva D.E., Kuchaeva D.B., Edrenkina A.D., Saratova A.A., Gaysina A.R., Leshchishina O.Y., 20262026Масягутов Т.А., Гутов М.Р., Галамай В.В., Миндиярова Д.С., Гайнуллин У.Р., Хашерова Д.Р., Сиразетдинова А.В., Кучаева Д.Э., Кучаева Д.Б., Едренкина А.Д., Саратова А.А., Гайсина А.Р., Лещишина О.Ю.Masyagutov T.A., Gutov M.R., Galamay V.V., Mindiyarova D.S., Gainullin U.R., Khasherova D.R., Sirazetdinova A.V., Kuchaeva D.E., Kuchaeva D.B., Edrenkina A.D., Saratova A.A., Gaysina A.R., Leshchishina O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2892Introduction

Introduction. Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder in women of reproductive age associated with high cardiometabolic risk.

Aim

Aim: to analyze current data on the prevalence, developmental mechanisms, and clinical significance of cardiometabolic disorders in patients with PCOS, and to substantiate approaches to multidisciplinary prevention and follow-up care.

Materials and Methods

Materials and Methods. A narrative review of publications from 2017 to 2026 was conducted using PubMed/MEDLINE, ScienceDirect, Google Scholar, and eLibrary databases. For this, international clinical guidelines, systematic reviews, meta-analyses, randomized controlled trials, and clinically relevant cohort studies were prioritized.

Results

Results. Cardiometabolic risk in PCOS is driven by a high prevalence of insulin resistance, dyslipidemia, arterial hypertension, and obesity. In clinical practice, assessment of glycemic status (preferably via an oral glucose tolerance test), lipid profile, blood pressure, and anthropometric parameters, rather than routine calculation of insulin resistance indices should be prioritized. The importance of comprehensive non-pharmacological prevention (diet, exercise, psychotherapeutic support) and the use of metformin or anti-obesity drugs according to indications is substantiated.

Conclusion

Conclusion. PCOS is associated with a high prevalence of cardiometabolic disorders driven by insulin resistance, visceral obesity, hyperandrogenism, and chronic inflammation, warranting a long-term multidisciplinary follow-up model with continuous prevention and pharmacotherapy when indicated.

Введение

Введение. Синдром поликистозных яичников (СПКЯ) – распространенная эндокринно-метаболическая патология репродуктивного возраста, ассоциированная с высоким кардиометаболическим риском.

Цель

Цель: проанализировать современные данные о распространенности, механизмах развития и клиническом значении кардиометаболических нарушений при СПКЯ, а также обосновать подходы к междисциплинарной профилактике и динамическому наблюдению.

Материалы и методы

Материалы и методы. Проведен нарративный обзор публикаций за 2017–2026 гг. в базах PubMed/MEDLINE, ScienceDirect, Google Scholar и eLibrary. Приоритет отдавался международным рекомендациям, систематическим обзорам, метаанализам, рандомизированным исследованиям и клинически значимым когортным данным.

Результаты

Результаты. Кардиометаболический риск при СПКЯ обусловлен высокой распространенностью инсулинорезистентности, дислипидемии, артериальной гипертензии и ожирения. В клинической практике приоритет должен отдаваться оценке гликемического статуса (предпочтительно с помощью орального глюкозотолерантного теста), липидного профиля, артериального давления и антропометрических показателей, а не рутинному расчету индексов инсулинорезистентности. Обоснована значимость комплексной немедикаментозной профилактики (диета, физические нагрузки, психотерапевтическая поддержка) и применения метформина или средств коррекции ожирения по показаниям.

Заключение

Заключение. СПКЯ ассоциирован с высокой распространенностью кардиометаболических нарушений, обусловленных инсулинорезистентностью, висцеральным ожирением, гиперандрогенией и хроническим воспалением, что требует долгосрочной междисциплинарной модели наблюдения с непрерывной профилактикой и медикаментозной коррекцией по показаниям. 

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The authors declare that there are no conflicts of interest present.