akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.791akusherstvo-2886Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРPregravid preparation, antenatal care, and prevention of obstetric complications in women of advanced reproductive age: a literature reviewПрегравидарная подготовка, антенатальное наблюдение и профилактика акушерских осложнений у женщин старшего репродуктивного возраста: обзор литературыhttps://orcid.org/0009-0009-9792-2709МуфазаловаА. А.MufazalovaA. A.

Муфазалова Алина Артуровна

450008 Уфа, ул. Ленина, д. 3

Alina A. Mufazalova

3 Lenin Str., Ufa 450008

alinamufazalova@inbox.ruhttps://orcid.org/0009-0001-1846-225XХакимовИ. А.KhakimovI. A.

Хакимов Ильдар Айдарович

450008 Уфа, ул. Ленина, д. 3

Ildar A. Khakimov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0008-7822-1678ДмитриеваА. А.DmitrievaA. A.

Дмитриева Арина Андреевна

450008 Уфа, ул. Ленина, д. 3

Arina A. Dmitrieva

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0002-2772-1214ГатауллинР. В.GataullinR. V.

Гатауллин Радмир Васимович

450008 Уфа, ул. Ленина, д. 3

Radmir V. Gataullin

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0003-8283-0795АртемьеваП. А.ArtemyevaP. A.

Артемьева Полина Алексеевна

450008 Уфа, ул. Ленина, д. 3

Polina A. Artemyeva

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-4764-0994ГадельшинаА. З.GadelshinaA. Z.

Гадельшина Аида Зимфировна

450008 Уфа, ул. Ленина, д. 3

Aida Z. Gadelshina

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0009-6170-7150ЗариповаИ. И.ZaripovaI. I.

Зарипова Ильнара Ильдаровна

450008 Уфа, ул. Ленина, д. 3

Ilnara I. Zaripova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0004-4354-5286ИвановаЕ. В.IvanovaE. V.

Иванова Екатерина Вячеславовна

450008 Уфа, ул. Ленина, д. 3

Ekaterina V. Ivanova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0006-9828-2211ИшкиеваА. И.IshkievaA. I.

Ишкиева Анастасия Ильфатовна

450008 Уфа, ул. Ленина, д. 3

Anastasia I. Ishkieva

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0004-5187-0484КамаловаА. Р.KamalovaA. R.

Камалова Амина Руслановна

450008 Уфа, ул. Ленина, д. 3

Amina R. Kamalova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-5097-8339ЛатыповаЭ. Р.LatypovaE. R.

Латыпова Элла Рамилевна

450008 Уфа, ул. Ленина, д. 3

Ella R. Latypova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0002-1557-2530ТазитовД. Е.TazitovD. E.

Тазитов Динис Евгеньевич

450008 Уфа, ул. Ленина, д. 3

Dinis E. Tazitov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0004-4418-2085ТерегуловТ. Р.TeregulovT. R.

Терегулов Таминдар Ринатович

450008 Уфа, ул. Ленина, д. 3

Tamindar R. Teregulov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0004-8170-5201ФархуллинаВ. И.FarkhullinaV. I.

Фархуллина Велена Ильдаровна

450008 Уфа, ул. Ленина, д. 3

Velena I. Farkhullina

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0005-7714-3231ХарисоваА. Ф.KharisovaA. F.

Харисова Алина Фирдусовна

450008 Уфа, ул. Ленина, д. 3

Alina F. Kharisova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0009-9385-1077ШайдуллинаР. Р.KharisovaR. R.

Шайдуллина Рената Рамилевна

450008 Уфа, ул. Ленина, д. 3

Renata R. Shaidullina

3 Lenin Str., Ufa 450008

ФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical UniversityRussian Federation20262507202600Online First2886Copyright © Mufazalova A.A., Khakimov I.A., Dmitrieva A.A., Gataullin R.V., Artemyeva P.A., Gadelshina A.Z., Zaripova I.I., Ivanova E.V., Ishkieva A.I., Kamalova A.R., Latypova E.R., Tazitov D.E., Teregulov T.R., Farkhullina V.I., Kharisova A.F., Kharisova R.R., 20262026Муфазалова А.А., Хакимов И.А., Дмитриева А.А., Гатауллин Р.В., Артемьева П.А., Гадельшина А.З., Зарипова И.И., Иванова Е.В., Ишкиева А.И., Камалова А.Р., Латыпова Э.Р., Тазитов Д.Е., Терегулов Т.Р., Фархуллина В.И., Харисова А.Ф., Шайдуллина Р.Р.Mufazalova A.A., Khakimov I.A., Dmitrieva A.A., Gataullin R.V., Artemyeva P.A., Gadelshina A.Z., Zaripova I.I., Ivanova E.V., Ishkieva A.I., Kamalova A.R., Latypova E.R., Tazitov D.E., Teregulov T.R., Farkhullina V.I., Kharisova A.F., Kharisova R.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2886

Aim: to summarize current evidence on reproductive health preservation in women of advanced reproductive age and to present clinically applicable approaches to preconception care, antenatal surveillance, and postpartum management.Materials and Methods. A review was conducted using publications indexed in PubMed/MEDLINE, eLibrary.ru, CyberLeninka, and Google Scholar from January 2014 to March 2026. Systematic reviews, meta-analyses, clinical guidelines, consensus statements, and original studies addressing age-related reproductive and obstetric risks were analyzed.Results. Advanced reproductive age is associated with increased risks of preeclampsia, gestational diabetes mellitus, preterm birth, fetal chromosomal abnormalities, and several perinatal complications. However, chronological age alone should not be used as the sole criterion for intensified surveillance. The most clinically relevant care-related components include preconception assessment of reproductive and somatic status, correction of modifiable risk factors, genetic counseling, selection of aneuploidy screening strategy, nutritional support, early preeclampsia risk assessment, screening for gestational diabetes mellitus, and individualized delivery timing.Conclusion. For women aged 35 years and older, a risk-oriented care model is clinically justified. The scope of assessment and preventive interventions should be determined not only by age but also by ovarian reserve, somatic comorbidity, obstetric history, and early antenatal screening results.

Цель: систематизировать современные данные о сохранении репродуктивного здоровья у женщин старшего репродуктивного возраста и представить клинически применимые подходы к преконцепционной подготовке, антенатальному наблюдению и послеродовому ведению.Материалы и методы. Выполнен нарративный обзор публикаций, индексируемых в PubMed/MEDLINE, eLibrary.ru, КиберЛенинка и Google Scholar, за период с января 2014 г. по март 2026 г. Рассматривались систематические обзоры, метаанализы, клинические рекомендации, консенсусные документы профессиональных сообществ и оригинальные исследования, посвященные возраст-ассоциированным репродуктивным и акушерским рискам.Результаты. Старший репродуктивный возраст ассоциирован с повышением риска преэклампсии, гестационного сахарного диабета, преждевременных родов, хромосомных аномалий плода и ряда перинатальных осложнений. Однако календарный возраст не должен рассматриваться как единственный критерий интенсификации наблюдения. Наиболее клинически значимыми компонентами ведения являются преконцепционная оценка репродуктивного и соматического статуса, коррекция модифицируемых факторов риска, медико-генетическое консультирование, выбор стратегии скрининга анеуплоидийнутритивная поддержка, ранняя оценка риска преэклампсии, диагностика гестационного сахарного диабета и индивидуализированное планирование срока родоразрешения.Заключение. Для женщин 35 лет и старше клинически оправдана риск-ориентированная модель ведения, в которой объем обследования и профилактических вмешательств определяется не только возрастом, но и овариальным резервом, соматической коморбидностью, акушерским анамнезом и результатами раннего антенатального скрининга

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The authors declare that there are no conflicts of interest present.