akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.771akusherstvo-2879Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРCurrent methods for assessing endometrial receptivity in in vitro fertilization: prognostic value and clinical applicabilityСовременные методы оценки рецептивности эндометрия при экстракорпоральном оплодотворении: прогностическая ценность и клиническая применимостьhttps://orcid.org/0009-0005-8770-0150ТитаренкоВ. Ю.TitarenkoV. Yu.

Титаренко Валерия Юрьевна 

350063 Краснодар, ул. Постовая, д. 18

Valeriya Yu. Titarenko, MD

18 Postovaya Str., Krasnodar 350063

valerivolik@yandex.ruhttps://orcid.org/0009-0002-0425-1723СмирноваЕ. Г.SmirnovaE. G.

Смирнова Елена Георгиевна 

194354 Санкт-Петербург, ул. Сикейроса, д. 10

Elena G. Smirnova, MD

10 Siqueirosa Str., Saint Petersburg 194354

https://orcid.org/0009-0008-5862-3784ОсиповаТ. А.OsipovaT. A.

Осипова Татьяна Алексеевна 

662311, Шарыпово, Пионерный микрорайн, д. 7

Tatiana A. Osipova, MD

7 Pioneer microdistrict, Sharypovo 662311

https://orcid.org/0009-0009-4434-3543РуноваД. Б.RunovaD. B.

Рунова Дарья Борисовна 

420138, Казань, ул. Оренбургский тракт, д. 140

Daria B. Runova, MD

140 Orenburgsky Trakt Str., Kazan, 420138

https://orcid.org/0009-0001-6661-676XАгаджанянА. П.AgadzhanyanA. P.

Агаджанян Анна Павловна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Anna P. Agadzhanyan

29 Nakhichevansky Lane, Rostov-on-Don 344022

https://orcid.org/0009-0008-2305-4366ЯрдушкинаО. О.YardushkinaO. O.

Ярдушкина Ольга Олеговна 

428015 Чебоксары, Московский проспект, д. 15

Olga O. Yardushkina

15 Moskovsky Prospekt, Cheboksary 428015

https://orcid.org/0009-0002-1066-0400МорозоваВ. А.MorozovaV. A.

Морозова Вероника Александровна

420012 Казань, ул. Бутлерова, д. 49

Veronika A. Morozova

49 Butlerova Str., Kazan 420012

https://orcid.org/0009-0001-3042-4643ЗенцоваВ. С.ZentsovaV. S.

Зенцова Валерия Сергеевна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Valeriya S. Zentsova

29 Nakhichevansky Lane, Rostov-on-Don 344022

https://orcid.org/0009-0002-2443-9336ХачаповаЖ. М.KhachapovaZh. M.

Хачапова Жанна Магомедовна 

385000 Майкоп, ул. Первомайская, д. 191

Zhanna M. Khachapova

191 Pervomaiskaya Str., Maikop 385000

https://orcid.org/0009-0001-0333-6752СултыговН. М.SultygovN. M.

Султыгов Накир Магомедович 

385000 Майкоп, ул. Первомайская, д. 191

Nakir M. Sultygov

191 Pervomaiskaya Str., Maikop 385000

https://orcid.org/0009-0006-3485-2350ЗубковаМ. Д.ZubkovaM. D.

Зубкова Мария Дмитриевна 

660022 Красноярск, ул. Партизана Железняка, д. 1

Maria D. Zubkova

1 Partizana Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0009-0009-0250-4417ТимохинаО. Ю.TimokhinaO. Yu.

Тимохина Олеся Юрьевна 

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Olesya Yu. Timokhina

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0009-0007-4455-5808ГюльмагомедоваА. Э.GyulmagomedovaA. E.

Гюльмагомедова Аминат Эльдаровна

Aminat E. Gyulmagomedova, MD

ГБУЗ «Городская поликлиника № 26»РоссияCity Polyclinic No. 26Russian FederationГБУЗ «Городская поликлиника № 104»РоссияCity Polyclinic No. 104Russian FederationКГБУЗ «Шарыповская центральная районная больница»РоссияSharypovskaya Central District HospitalRussian FederationГАУЗ «Детская республиканская клиническая больница» Министерства здравоохранения Республики ТатарстанРоссияChildren's Republican Clinical HospitalRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет»РоссияRostov State Medical UniversityRussian FederationФГБОУ ВО «Чувашский государственный университет имени И.Н. Ульянова»РоссияUlyanov Chuvash State UniversityRussian FederationФГБОУ ВО «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Майкопский государственный технологический университет»РоссияMaikop State Technological UniversityRussian FederationФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian FederationRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationНезависимый исследовательРоссияIndependent ResearcherRussian Federation20261307202600Online First2879Copyright © Titarenko V.Y., Smirnova E.G., Osipova T.A., Runova D.B., Agadzhanyan A.P., Yardushkina O.O., Morozova V.A., Zentsova V.S., Khachapova Z.M., Sultygov N.M., Zubkova M.D., Timokhina O.Y., Gyulmagomedova A.E., 20262026Титаренко В.Ю., Смирнова Е.Г., Осипова Т.А., Рунова Д.Б., Агаджанян А.П., Ярдушкина О.О., Морозова В.А., Зенцова В.С., Хачапова Ж.М., Султыгов Н.М., Зубкова М.Д., Тимохина О.Ю., Гюльмагомедова А.Э.Titarenko V.Y., Smirnova E.G., Osipova T.A., Runova D.B., Agadzhanyan A.P., Yardushkina O.O., Morozova V.A., Zentsova V.S., Khachapova Z.M., Sultygov N.M., Zubkova M.D., Timokhina O.Y., Gyulmagomedova A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2879

Endometrial receptivity is a key factor in successful embryo implantation and one of the most difficult-to-assess parameters in reproductive medicine. Despite the wide range of diagnostic approaches, their clinical effectiveness remains debated. This narrative review is based on analyzing publications indexed in PubMed/MEDLINE, Scopus, and Web of Science, focusing on systematic reviews, randomized studies, as well as prospective and retrospective cohort studies aimed at evaluating endometrial receptivity in in vitro fertilization programs. The review analyzes morphological functional, molecular, and integrative approaches, and compares their clinical value regarding implantation outcomes, clinical pregnancy, and live birth. It is shown that morphological and ultrasonographic parameters are characterized by limited prognostic value and high interindividual variability. Functional methods, including assessment of blood flow and uterine peristaltic activity, demonstrate a closer relation to implantation outcomes, although their results remain heterogeneous. Molecular and cellular markers in several studies show higher diagnostic accuracy, but this not accompanied by convincingly improved live birth rates. The most studied transcriptomic tests of endometrial receptivity demonstrate no superiority compared with standard embryo transfer timing in the general patient population. Therefore, none of the existing methods has sufficient prognostic accuracy for independent clinical use. A promising approach is development of integrative diagnostic models that combine clinical, functional, and molecular parameters, followed by validation in large prospective studies.

Рецептивность эндометрия является ключевым фактором успешной имплантации эмбриона и одним из наиболее сложных для оценки параметров в репродуктивной медицине. Несмотря на широкий спектр диагностических подходов, их клиническая эффективность остается предметом дискуссии. Настоящий нарративный обзор основан на анализе публикаций, индексированных в PubMed/MEDLINE, Scopus и Web of Science, с акцентом на систематические обзоры, рандомизированные исследования, проспективные и ретроспективные когортные работы, посвященные оценке рецептивности эндометрия в программах экстракорпорального оплодотворения. В обзоре проанализированы морфологические, функциональные, молекулярные и интегративные подходы, а также сопоставлена их клиническая ценность в отношении исходов имплантации, клинической беременности и живорождения. Показано, что морфологические и ультразвуковые параметры характеризуются ограниченной прогностической ценностью и высокой межиндивидуальной вариабельностью. Функциональные методы, включая оценку кровотока и перистальтической активности матки, демонстрируют более тесную связь с исходами имплантации, при этом их результаты остаются неоднородными. Молекулярные и клеточные маркеры в ряде исследований показывают более высокую диагностическую точность, но это не сопровождается убедимым улучшением частоты живорождения. Наиболее изученные транскриптомные тесты рецептивности эндометрия не демонстрируют преимуществ по сравнению со стандартным временем переноса эмбрионов в общей популяции пациенток. Следовательно, ни один из существующих методов не обладает достаточной прогностической точностью для самостоятельного клинического применения. Перспективным направлением является разработка интегративных диагностических моделей, объединяющих клинические, функциональные и молекулярные параметры, с последующей валидацией в крупных проспективных исследованиях.

рецептивность эндометрияокно имплантациивспомогательные репродуктивные технологииимплантация эмбрионатолщина эндометриядоплерометрияперистальтика маткимолекулярные маркерытест рецептивности эндометриямикробиота эндометрияеndometrial receptivitywindow of implantationassisted reproductive technologiesembryo implantationendometrial thicknessDoppler ultrasonographyuterine contractilitymolecular markersendometrial receptivity testendometrial microbiotaReferencesESHRE Working Group on Recurrent Implantation Failure, Cimadomo D., de Los Santos M.J., Griesinger G. et al. ESHRE good practice recommendations on recurrent implantation failure. Hum Reprod Open. 2023;(3):hoad023. https://doi.org/10.1093/hropen/hoad023.ESHRE Working Group on Recurrent Implantation Failure, Cimadomo D., de Los Santos M.J., Griesinger G. et al. ESHRE good practice recommendations on recurrent implantation failure. Hum Reprod Open. 2023;(3):hoad023. https://doi.org/10.1093/hropen/hoad023.Pirtea P., Cedars M.I., Devine K. et al. Recurrent implantation failure: reality or a statistical mirage? Fertil Steril. 2023;120(1):45–59. https://doi.org/10.1016/j.fertnstert.2023.02.014.Pirtea P., Cedars M.I., Devine K. et al. Recurrent implantation failure: reality or a statistical mirage? Fertil Steril. 2023;120(1):45–59. https://doi.org/10.1016/j.fertnstert.2023.02.014.Rahman S.M., Chakraborty P. Recurrent implantation failure: etiology, treatment strategies and contemporary clinical perspectives. J Indian Med Assoc. 2026;124(2):54–8. https://doi.org/10.5005/JIMA-1107-124_02_11.Rahman S.M., Chakraborty P. Recurrent implantation failure: etiology, treatment strategies and contemporary clinical perspectives. J Indian Med Assoc. 2026;124(2):54–8. https://doi.org/10.5005/JIMA-1107-124_02_11.Polanski L.T., Baumgarten M.N., Quenby S. et al. What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion. Reprod Biomed Online. 2014;28(4):409–23. https://doi.org/10.1016/j.rbmo.2013.12.006.Polanski L.T., Baumgarten M.N., Quenby S. et al. What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion. Reprod Biomed Online. 2014;28(4):409–23. https://doi.org/10.1016/j.rbmo.2013.12.006.Hviid M.M., Macklon N. Immune modulation treatments – where is the evidence? Fertil Steril. 2017;107(6):1284–93. https://doi.org/10.1016/j.fertnstert.2017.04.009.Hviid M.M., Macklon N. Immune modulation treatments – where is the evidence? Fertil Steril. 2017;107(6):1284–93. https://doi.org/10.1016/j.fertnstert.2017.04.009.Sebastian-Leon P., Garrido N., Remohí J. et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod. 2018;33(4):626–35. https://doi.org/10.1093/humrep/dey023.Sebastian-Leon P., Garrido N., Remohí J. et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod. 2018;33(4):626–35. https://doi.org/10.1093/humrep/dey023.Orazov M.R., Radzinskiy V.E., Kostin I.N. et al. Endometrial asynchrony in pathogenesis of implantation impairment in women with infertility associated with endometriosis. Gynecol Endocrinol. 2021;37(sup1):1–3. https://doi.org/10.1080/09513590.2021.2006437.Orazov M.R., Radzinskiy V.E., Kostin I.N. et al. Endometrial asynchrony in pathogenesis of implantation impairment in women with infertility associated with endometriosis. Gynecol Endocrinol. 2021;37(sup1):1–3. https://doi.org/10.1080/09513590.2021.2006437.Kitaya K., Yasuo T. Commonalities and disparities between endometriosis and chronic endometritis: therapeutic potential of novel antibiotic treatment strategy against ectopic endometrium. Int J Mol Sci. 2023;24(3):2059. https://doi.org/10.3390/ijms24032059.Kitaya K., Yasuo T. Commonalities and disparities between endometriosis and chronic endometritis: therapeutic potential of novel antibiotic treatment strategy against ectopic endometrium. Int J Mol Sci. 2023;24(3):2059. https://doi.org/10.3390/ijms24032059.Ata B. Why does the recurrent implantation failure literature need to be rewritten? Hum Reprod Open. 2025;(3):hoaf035. https://doi.org/10.1093/hropen/hoaf035.Ata B. Why does the recurrent implantation failure literature need to be rewritten? Hum Reprod Open. 2025;(3):hoaf035. https://doi.org/10.1093/hropen/hoaf035.Mathyk B., Schwartz A., DeCherney A., Ata B. A critical appraisal of studies on endometrial thickness and embryo transfer outcome. Reprod Biomed Online. 2023;47(4):103259. https://doi.org/10.1016/j.rbmo.2023.103259.Mathyk B., Schwartz A., DeCherney A., Ata B. A critical appraisal of studies on endometrial thickness and embryo transfer outcome. Reprod Biomed Online. 2023;47(4):103259. https://doi.org/10.1016/j.rbmo.2023.103259.Alfer J., Fattahi A., Bleisinger N. et al. Endometrial dating method detects individual maturation sequences during the secretory phase. In Vivo. 2020;34(4):1951–63. https://doi.org/10.21873/invivo.11992.Alfer J., Fattahi A., Bleisinger N. et al. Endometrial dating method detects individual maturation sequences during the secretory phase. In Vivo. 2020;34(4):1951–63. https://doi.org/10.21873/invivo.11992.Alfer J., Popovici R.M., Fattahi A. et al. Endometrial delay is found to be part of a normal individual dynamic transformation process. Arch Gynecol Obstet. 2021;304(6):1599–609. 10.1007/s00404-021-06086-8.Alfer J., Popovici R.M., Fattahi A. et al. Endometrial delay is found to be part of a normal individual dynamic transformation process. Arch Gynecol Obstet. 2021;304(6):1599–609. 10.1007/s00404-021-06086-8.Young S.L., Savaris R.F., Lessey B.A. et al. Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod. 2017;32(9):1903–14. https://doi.org/10.1093/humrep/dex252.Young S.L., Savaris R.F., Lessey B.A. et al. Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod. 2017;32(9):1903–14. https://doi.org/10.1093/humrep/dex252.Li Y., Li X.F., Liao J.N. et al. Clinical value of histologic endometrial dating for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles. BMC Pregnancy Childbirth. 2020;20(1):527. https://doi.org/10.1186/s12884-020-03217-y.Li Y., Li X.F., Liao J.N. et al. Clinical value of histologic endometrial dating for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles. BMC Pregnancy Childbirth. 2020;20(1):527. https://doi.org/10.1186/s12884-020-03217-y.Li Y., Wen Q., Hu J. et al. Histological endometrial dating: a reliable tool for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles. BMC Pregnancy Childbirth. 2023;23(1):199. https://doi.org/10.1186/s12884-023-05512-w.Li Y., Wen Q., Hu J. et al. Histological endometrial dating: a reliable tool for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles. BMC Pregnancy Childbirth. 2023;23(1):199. https://doi.org/10.1186/s12884-023-05512-w.Quinn K.E., Matson B.C., Wetendorf M., Caron K.M. Pinopodes: Recent advancements, current perspectives, and future directions. Mol Cell Endocrinol. 2020;501:110644. https://doi.org/10.1016/j.mce.2019.110644.Quinn K.E., Matson B.C., Wetendorf M., Caron K.M. Pinopodes: Recent advancements, current perspectives, and future directions. Mol Cell Endocrinol. 2020;501:110644. https://doi.org/10.1016/j.mce.2019.110644.Zhao L., Yin F., Hu X. et al. Pinopode versus endometrial receptivity analysis for personalized embryo transfer in recurrent implantation failure. Reprod Biomed Online. 2025;51(2):104875. https://doi.org/10.1016/j.rbmo.2025.104875.Zhao L., Yin F., Hu X. et al. Pinopode versus endometrial receptivity analysis for personalized embryo transfer in recurrent implantation failure. Reprod Biomed Online. 2025;51(2):104875. https://doi.org/10.1016/j.rbmo.2025.104875.Zhu M.B., Chen B.L., Cen M. et al. Comparative analysis of endometrial gland imaging and pinopode detection for assessing endometrial receptivity. Reprod Biol Endocrinol. 2025;23(1):62. https://doi.org/10.1186/s12958-025-01395-y.Zhu M.B., Chen B.L., Cen M. et al. Comparative analysis of endometrial gland imaging and pinopode detection for assessing endometrial receptivity. Reprod Biol Endocrinol. 2025;23(1):62. https://doi.org/10.1186/s12958-025-01395-y.Liao Z., Liu C., Cai Let al. The effect of endometrial thickness on pregnancy, maternal, and perinatal outcomes of women in fresh cycles after IVF/ICSI: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022;12:814648. https://doi.org/10.3389/fendo.2021.814648.Liao Z., Liu C., Cai Let al. The effect of endometrial thickness on pregnancy, maternal, and perinatal outcomes of women in fresh cycles after IVF/ICSI: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022;12:814648. https://doi.org/10.3389/fendo.2021.814648.Wang C., Yang C., Dai W. et al. The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study. Front Endocrinol (Lausanne). 2025;16:1637587. https://doi.org/10.3389/fendo.2025.1637587.Wang C., Yang C., Dai W. et al. The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study. Front Endocrinol (Lausanne). 2025;16:1637587. https://doi.org/10.3389/fendo.2025.1637587.Zhang J., Sun Y.F., Xu Y.M. et al. Effect of endometrium thickness on clinical outcomes in luteal phase short-acting GnRH-a long protocol and GnRH-ant protocol. Front Endocrinol (Lausanne). 2021;12:578783. https://doi.org/10.3389/fendo.2021.578783.Zhang J., Sun Y.F., Xu Y.M. et al. Effect of endometrium thickness on clinical outcomes in luteal phase short-acting GnRH-a long protocol and GnRH-ant protocol. Front Endocrinol (Lausanne). 2021;12:578783. https://doi.org/10.3389/fendo.2021.578783.Ke X., Liang X., Wang M., Shao X. Endometrial thickness/volume and uterine peristalsis in adenomyosis patients undergoing frozen embryo transfer to predict pregnancy outcomes: a retrospective study. Medicine (Baltimore). 2025;104(39):e44907. https://doi.org/10.1097/MD.0000000000044907.Ke X., Liang X., Wang M., Shao X. Endometrial thickness/volume and uterine peristalsis in adenomyosis patients undergoing frozen embryo transfer to predict pregnancy outcomes: a retrospective study. Medicine (Baltimore). 2025;104(39):e44907. https://doi.org/10.1097/MD.0000000000044907.Wang L., Lv S., Mao W. et al. Fecundity disorders in older women: declines in follicular development and endometrial receptivity. BMC Womens Health. 2020;20(1):115. https://doi.org/10.1186/s12905-020-00979-7.Wang L., Lv S., Mao W. et al. Fecundity disorders in older women: declines in follicular development and endometrial receptivity. BMC Womens Health. 2020;20(1):115. https://doi.org/10.1186/s12905-020-00979-7.Siargkas A., Faka A., Kripouri P. et al. Association of pre-implantation uterine artery Doppler with clinical pregnancy in assisted reproductive technology: a systematic review and meta-analysis. Medicina (Kaunas). 2025;61(6):1004. https://doi.org/10.3390/medicina61061004.Siargkas A., Faka A., Kripouri P. et al. Association of pre-implantation uterine artery Doppler with clinical pregnancy in assisted reproductive technology: a systematic review and meta-analysis. Medicina (Kaunas). 2025;61(6):1004. https://doi.org/10.3390/medicina61061004.Ke X., Liang X.F., Lin Y.H., Wang F. Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study. Reprod Biol Endocrinol. 2023;21(1):112. https://doi.org/10.1186/s12958-023-01164-9.Ke X., Liang X.F., Lin Y.H., Wang F. Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study. Reprod Biol Endocrinol. 2023;21(1):112. https://doi.org/10.1186/s12958-023-01164-9.Cheng F., Xv B.M., Liu Y.L. et al. Endometrial microstimulation effects on endometrial receptivity assessed by transvaginal color Doppler sonography. BMC Womens Health. 2022;22(1):508. https://doi.org/10.1186/s12905-022-02096-z.Cheng F., Xv B.M., Liu Y.L. et al. Endometrial microstimulation effects on endometrial receptivity assessed by transvaginal color Doppler sonography. BMC Womens Health. 2022;22(1):508. https://doi.org/10.1186/s12905-022-02096-z.Zang Z., Lyu J., Yan Y. et al. Subendometrial blood flow detected by Doppler ultrasound associates with pregnancy outcomes of frozen embryo transfer in patients with thin endometrium. J Assist Reprod Genet. 2024;41(10):2625–33. https://doi.org/10.1007/s10815-024-03245-z.Zang Z., Lyu J., Yan Y. et al. Subendometrial blood flow detected by Doppler ultrasound associates with pregnancy outcomes of frozen embryo transfer in patients with thin endometrium. J Assist Reprod Genet. 2024;41(10):2625–33. https://doi.org/10.1007/s10815-024-03245-z.Sadek S., Matitashvili T., Kovac A. et al. Assessment of uterine receptivity by endometrial and sub-endometrial blood flow using SlowflowHD in hormone prepared frozen embryo transfer cycles: a pilot study. J Assist Reprod Genet. 2022;39(5):1069–79. https://doi.org/10.1007/s10815-022-02454-8.Sadek S., Matitashvili T., Kovac A. et al. Assessment of uterine receptivity by endometrial and sub-endometrial blood flow using SlowflowHD in hormone prepared frozen embryo transfer cycles: a pilot study. J Assist Reprod Genet. 2022;39(5):1069–79. https://doi.org/10.1007/s10815-022-02454-8.Zhang C.H., Chen C., Wang J.R. et al. An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography. Front Endocrinol (Lausanne). 2022:13:907874. https://doi.org/10.3389/fendo.2022.907874.Zhang C.H., Chen C., Wang J.R. et al. An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography. Front Endocrinol (Lausanne). 2022:13:907874. https://doi.org/10.3389/fendo.2022.907874.Indrakanti P., Mundkur A., Poojari V.G. et al. Uterine biophysical profile after intrauterine instillation of autologous blood cell derivative (ABCD) for thin endometrium in frozen embryo transfer cycles. Arch Gynecol Obstet. 2026;313(1):82. https://doi.org/10.1007/s00404-026-08345-y.Indrakanti P., Mundkur A., Poojari V.G. et al. Uterine biophysical profile after intrauterine instillation of autologous blood cell derivative (ABCD) for thin endometrium in frozen embryo transfer cycles. Arch Gynecol Obstet. 2026;313(1):82. https://doi.org/10.1007/s00404-026-08345-y.Sun K., Xiu Y., Wang Y. et ak. Predictive value of 3D ultrasound assessment of endometrial receptivity for PGD/PGS for transfer pregnancy outcome. BMC Pregnancy Childbirth. 2023;23(1):213. https://doi.org/10.1186/s12884-023-05534-4.Sun K., Xiu Y., Wang Y. et ak. Predictive value of 3D ultrasound assessment of endometrial receptivity for PGD/PGS for transfer pregnancy outcome. BMC Pregnancy Childbirth. 2023;23(1):213. https://doi.org/10.1186/s12884-023-05534-4.Peng L., Zhou W.Q., Mao C.P. et al. Predictive value of endometrial receptivity evaluated by three-dimensional ultrasound in ectopic pregnancy after in vitro fertilization-embryo transfer. Eur Rev Med Pharmacol Sci. 2023;27(7):3009–15. https://doi.org/10.26355/eurrev_202304_31934.Peng L., Zhou W.Q., Mao C.P. et al. Predictive value of endometrial receptivity evaluated by three-dimensional ultrasound in ectopic pregnancy after in vitro fertilization-embryo transfer. Eur Rev Med Pharmacol Sci. 2023;27(7):3009–15. https://doi.org/10.26355/eurrev_202304_31934.Wang C., Lin J., Zhao X. et al. Analysis of ultrasound parameters influencing endometrial receptivity and a pregnancy outcomes predictive model for patients undergoing in vitro fertilization and embryo transfer: a prospective study. Front Endocrinol (Lausanne). 2025;16:1677593. https://doi.org/10.3389/fendo.2025.1677593.Wang C., Lin J., Zhao X. et al. Analysis of ultrasound parameters influencing endometrial receptivity and a pregnancy outcomes predictive model for patients undergoing in vitro fertilization and embryo transfer: a prospective study. Front Endocrinol (Lausanne). 2025;16:1677593. https://doi.org/10.3389/fendo.2025.1677593.Zhang Q., Wang X., Zhang Y. et al. Nomogram prediction for the prediction of clinical pregnancy in Freeze-thawed Embryo Transfer. BMC Pregnancy Childbirth. 2022;22(1):629. https://doi.org/10.1186/s12884-022-04958-8.Zhang Q., Wang X., Zhang Y. et al. Nomogram prediction for the prediction of clinical pregnancy in Freeze-thawed Embryo Transfer. BMC Pregnancy Childbirth. 2022;22(1):629. https://doi.org/10.1186/s12884-022-04958-8.Liao J., Yang S., Chen K. , et al. A predictive model for first-trimester pregnancy inception after IVF-ET based on multimodal ultrasound evaluation of endometrial receptivity. BMC Med Imaging. 2022;22(1):158. doi: https://doi.org/10.1186/s12880-022-00863-w.Liao J., Yang S., Chen K. , et al. A predictive model for first-trimester pregnancy inception after IVF-ET based on multimodal ultrasound evaluation of endometrial receptivity. BMC Med Imaging. 2022;22(1):158. doi: https://doi.org/10.1186/s12880-022-00863-w.Kudlay D., Kiselev V., Sukhikh G. HOXA10 and HOXA11 methylation: epigenetic barriers to endometrial receptivity in ART. Genes (Basel). 2025;16(10):1230. https://doi.org/10.3390/genes16101230.Kudlay D., Kiselev V., Sukhikh G. HOXA10 and HOXA11 methylation: epigenetic barriers to endometrial receptivity in ART. Genes (Basel). 2025;16(10):1230. https://doi.org/10.3390/genes16101230.Wang M.L., Lu B.J., Lu X. et al. Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure. Sci Rep. 2026;16(1):9754. https://doi.org/10.1038/s41598-026-40386-w.Wang M.L., Lu B.J., Lu X. et al. Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure. Sci Rep. 2026;16(1):9754. https://doi.org/10.1038/s41598-026-40386-w.Moreno I., Garcia-Grau I., Perez-Villaroya D. et al. Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022;10(1):1. https://doi.org/10.1186/s40168-021-01184-w.Moreno I., Garcia-Grau I., Perez-Villaroya D. et al. Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022;10(1):1. https://doi.org/10.1186/s40168-021-01184-w.Amrani M., Renné C., Blaschke V. et al. Chronic endometritis identified by plasma cells can often be diagnosed in patients with recurrent implantation failure. Eur J Obstet Gynecol Reprod Biol. 2025;312:114092. https://doi.org/10.1016/j.ejogrb.2025.114092.Amrani M., Renné C., Blaschke V. et al. Chronic endometritis identified by plasma cells can often be diagnosed in patients with recurrent implantation failure. Eur J Obstet Gynecol Reprod Biol. 2025;312:114092. https://doi.org/10.1016/j.ejogrb.2025.114092.Arian S.E., Hessami K., Khatibi A. et al. Endometrial receptivity array before frozen embryo transfer cycles: a systematic review and meta-analysis. Fertil Steril. 2023;119(2):229–38. https://doi.org/10.1016/j.fertnstert.2022.11.012.Arian S.E., Hessami K., Khatibi A. et al. Endometrial receptivity array before frozen embryo transfer cycles: a systematic review and meta-analysis. Fertil Steril. 2023;119(2):229–38. https://doi.org/10.1016/j.fertnstert.2022.11.012.Doyle N., Jahandideh S., Hill M.J. et al K. Effect of timing by endometrial receptivity testing vs Standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization: a randomized clinical trial. JAMA. 2022;328(21):2117–25. https://doi.org/10.1001/jama.2022.20438.Doyle N., Jahandideh S., Hill M.J. et al K. Effect of timing by endometrial receptivity testing vs Standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization: a randomized clinical trial. JAMA. 2022;328(21):2117–25. https://doi.org/10.1001/jama.2022.20438.Mei Y., Wang Y., Ke X. et al. Does endometrial receptivity array improve reproductive outcomes in euploid embryo transfer cycles? Aa systematic review. Front Endocrinol (Lausanne). 2023;14:1251699. https://doi.org/10.3389/fendo.2023.1251699.Mei Y., Wang Y., Ke X. et al. Does endometrial receptivity array improve reproductive outcomes in euploid embryo transfer cycles? Aa systematic review. Front Endocrinol (Lausanne). 2023;14:1251699. https://doi.org/10.3389/fendo.2023.1251699.Liu Z., Liu X., Wang M et al. The Clinical efficacy of personalized embryo transfer guided by the endometrial receptivity array/analysis on IVF/ICSI outcomes: a systematic review and meta-analysis. Front Physiol. 2022;13:841437. https://doi.org/10.3389/fphys.2022.841437.Liu Z., Liu X., Wang M et al. The Clinical efficacy of personalized embryo transfer guided by the endometrial receptivity array/analysis on IVF/ICSI outcomes: a systematic review and meta-analysis. Front Physiol. 2022;13:841437. https://doi.org/10.3389/fphys.2022.841437.He A., Wu H., Zou Y. et al. Can biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study. Reprod Biol Endocrinol. 2023;21(1):20. https://doi.org/10.1186/s12958-023-01070-0.He A., Wu H., Zou Y. et al. Can biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study. Reprod Biol Endocrinol. 2023;21(1):20. https://doi.org/10.1186/s12958-023-01070-0.Xu F., Zhang Y., Ma Q. et al. Prediction of clinical pregnancy after frozen embryo transfer based on ultrasound radiomics: an analysis based on the optimal periendometrial zone. BMC Pregnancy Childbirth. 2025;25(1):391. https://doi.org/10.1186/s12884-025-07508-0.Xu F., Zhang Y., Ma Q. et al. Prediction of clinical pregnancy after frozen embryo transfer based on ultrasound radiomics: an analysis based on the optimal periendometrial zone. BMC Pregnancy Childbirth. 2025;25(1):391. https://doi.org/10.1186/s12884-025-07508-0.Giacomini E., Scotti G.M., Vanni V.S. et al. Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation. Hum Reprod. 2021;36(8):2249–74. https://doi.org/10.1093/humrep/deab123.Giacomini E., Scotti G.M., Vanni V.S. et al. Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation. Hum Reprod. 2021;36(8):2249–74. https://doi.org/10.1093/humrep/deab123.Parvanov D., Ganeva R., Vidolova N., Stamenov G. Decreased number of p16-positive senescent cells in human endometrium as a marker of miscarriage. J Assist Reprod Genet. 2021;38(8):2087–95. https://doi.org/10.1007/s10815-021-02182-5.Parvanov D., Ganeva R., Vidolova N., Stamenov G. Decreased number of p16-positive senescent cells in human endometrium as a marker of miscarriage. J Assist Reprod Genet. 2021;38(8):2087–95. https://doi.org/10.1007/s10815-021-02182-5.Dang J., Xiao X., Li M. Correlation of hysteroscopic findings of chronic endometritis with CD138 immunohistochemistry and their correlation with pregnancy outcomes. J Assist Reprod Genet. 2024 Sep;41(9):2477–83. https://doi.org/10.1007/s10815-024-03204-8.Dang J., Xiao X., Li M. Correlation of hysteroscopic findings of chronic endometritis with CD138 immunohistochemistry and their correlation with pregnancy outcomes. J Assist Reprod Genet. 2024 Sep;41(9):2477–83. https://doi.org/10.1007/s10815-024-03204-8.Kalı Z., Karlı P., Tanılır F. et al. NF-κB as an inflammatory biomarker in thin endometrium: predictive value for live birth in recurrent implantation failure. Diagnostics (Basel). 2025;15(14):1762. https://doi.org/10.3390/diagnostics15141762.Kalı Z., Karlı P., Tanılır F. et al. NF-κB as an inflammatory biomarker in thin endometrium: predictive value for live birth in recurrent implantation failure. Diagnostics (Basel). 2025;15(14):1762. https://doi.org/10.3390/diagnostics15141762.Zolfaroli .I, Monzó Miralles A., Hidalgo-Mora J.J. et al. Impact of endometrial receptivity analysis on pregnancy outcomes in patients undergoing embryo transfer: a systematic review and meta-analysis. J Assist Reprod Genet. 2023;40(5):985–94. https://doi.org/10.1007/s10815-023-02791-2.Zolfaroli .I, Monzó Miralles A., Hidalgo-Mora J.J. et al. Impact of endometrial receptivity analysis on pregnancy outcomes in patients undergoing embryo transfer: a systematic review and meta-analysis. J Assist Reprod Genet. 2023;40(5):985–94. https://doi.org/10.1007/s10815-023-02791-2.Lu Y., Mao X., He Y. et al. Efficacy of endometrial receptivity testing for recurrent implantation failure in patients with euploid embryo transfers: study protocol for a randomized controlled trial. Trials. 2024;25(1):348. https://doi.org/10.1186/s13063-024-08125-6.Lu Y., Mao X., He Y. et al. Efficacy of endometrial receptivity testing for recurrent implantation failure in patients with euploid embryo transfers: study protocol for a randomized controlled trial. Trials. 2024;25(1):348. https://doi.org/10.1186/s13063-024-08125-6.Bourdon M., Maignien C., Ouazana M. et al. Oestradiol and reproductive outcomes in ART: when too much of a good thing hurts. Reprod Biomed Online. 2025;51(6):105131. https://doi.org/10.1016/j.rbmo.2025.105131.Bourdon M., Maignien C., Ouazana M. et al. Oestradiol and reproductive outcomes in ART: when too much of a good thing hurts. Reprod Biomed Online. 2025;51(6):105131. https://doi.org/10.1016/j.rbmo.2025.105131.Chao S.B., Wang Y.H., Li J.C. et al. Down-regulation ovulation-induction leads to favorable outcomes in a single frozen-thawed blastocyst transfer RCT. Front Endocrinol (Lausanne). 2022;13:797121. https://doi.org/10.3389/fendo.2022.797121.Chao S.B., Wang Y.H., Li J.C. et al. Down-regulation ovulation-induction leads to favorable outcomes in a single frozen-thawed blastocyst transfer RCT. Front Endocrinol (Lausanne). 2022;13:797121. https://doi.org/10.3389/fendo.2022.797121.Safarloo F., Zamaniyan M., Nazar E. et al. Comparison of clinical pregnancy rates between hormone replacement therapy and modified natural cycle for endometrial preparation in frozen embryo transfer cycles: an RCT. Int J Reprod Biomed. 2025;23(5):409–24. https://doi.org/10.18502/ijrm.v23i5.19264.Safarloo F., Zamaniyan M., Nazar E. et al. Comparison of clinical pregnancy rates between hormone replacement therapy and modified natural cycle for endometrial preparation in frozen embryo transfer cycles: an RCT. Int J Reprod Biomed. 2025;23(5):409–24. https://doi.org/10.18502/ijrm.v23i5.19264.Melo P., Chung Y., Pickering O. et al. Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis. Fertil Steril. 2021;116(6):1534–56. https://doi.org/10.1016/j.fertnstert.2021.07.002.Melo P., Chung Y., Pickering O. et al. Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis. Fertil Steril. 2021;116(6):1534–56. https://doi.org/10.1016/j.fertnstert.2021.07.002.Opuchlik K., Pankiewicz K., Pierzyński P. et al. Factors influencing endometrial receptivity in women with recurrent implantation failure. BMC Womens Health. 2025;25(1):15. https://doi.org/10.1186/s12905-024-03531-z.Opuchlik K., Pankiewicz K., Pierzyński P. et al. Factors influencing endometrial receptivity in women with recurrent implantation failure. BMC Womens Health. 2025;25(1):15. https://doi.org/10.1186/s12905-024-03531-z.Ben Rafael Z. Endometrial Receptivity Analysis (ERA) test: an unproven technology. Hum Reprod Open. 2021;2021(2):hoab010. https://doi.org/10.1093/hropen/hoab010.Ben Rafael Z. Endometrial Receptivity Analysis (ERA) test: an unproven technology. Hum Reprod Open. 2021;2021(2):hoab010. https://doi.org/10.1093/hropen/hoab010.Ruiz-Alonso M., Valbuena D., Gomez C. et al. Endometrial Receptivity Analysis (ERA): data versus opinions. Hum Reprod Open. 2021;2021(2):hoab011. https://doi.org/10.1093/hropen/hoab011.Ruiz-Alonso M., Valbuena D., Gomez C. et al. Endometrial Receptivity Analysis (ERA): data versus opinions. Hum Reprod Open. 2021;2021(2):hoab011. https://doi.org/10.1093/hropen/hoab011.Puente E., Alonso L., Laganà A.S. et al. Chronic endometritis: old problem, novel insights and future challenges. Int J Fertil Steril. 2020;13(4):250–6. https://doi.org/10.22074/ijfs.2020.5779.Puente E., Alonso L., Laganà A.S. et al. Chronic endometritis: old problem, novel insights and future challenges. Int J Fertil Steril. 2020;13(4):250–6. https://doi.org/10.22074/ijfs.2020.5779.Wu C., Sun Y., Yang D., Peng H. Advances in endometrial receptivity and embryo implantation by multi-omics techniques. Animals and Zoonoses. 2025;1(3):286–94. https://doi.org/10.1016/j.azn.2025.05.001Wu C., Sun Y., Yang D., Peng H. Advances in endometrial receptivity and embryo implantation by multi-omics techniques. Animals and Zoonoses. 2025;1(3):286–94. https://doi.org/10.1016/j.azn.2025.05.001Fang Q., Qiao Z., Luo L. et al. Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data. Reprod Biol Endocrinol. 2024;22(1):32. doi: https://doi.org/10.1186/s12958-024-01203-z.Fang Q., Qiao Z., Luo L. et al. Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data. Reprod Biol Endocrinol. 2024;22(1):32. doi: https://doi.org/10.1186/s12958-024-01203-z.Sharma M., Dubey P., Sunda U., Tilva H. A comprehensive review of the endometrial receptivity array in euploid embryo transfer cycles. Cureus. 2024;16(6):e63173. https://doi.org/10.7759/cureus.63173.Sharma M., Dubey P., Sunda U., Tilva H. A comprehensive review of the endometrial receptivity array in euploid embryo transfer cycles. Cureus. 2024;16(6):e63173. https://doi.org/10.7759/cureus.63173.Bajpai K., Acharya N., Prasad R., Wanjari M.B. Endometrial receptivity during the preimplantation period: a narrative review. Cureus. 2023;15(4):e37753. https://doi.org/10.7759/cureus.37753.Bajpai K., Acharya N., Prasad R., Wanjari M.B. Endometrial receptivity during the preimplantation period: a narrative review. Cureus. 2023;15(4):e37753. https://doi.org/10.7759/cureus.37753.Maziotis E., Kalampokas T., Giannelou P. et al. Commercially available molecular approaches to evaluate endometrial receptivity: a systematic review and critical analysis of the literature. Diagnostics (Basel). 2022;12(11):2611. https://doi.org/10.3390/diagnostics12112611.Maziotis E., Kalampokas T., Giannelou P. et al. Commercially available molecular approaches to evaluate endometrial receptivity: a systematic review and critical analysis of the literature. Diagnostics (Basel). 2022;12(11):2611. https://doi.org/10.3390/diagnostics12112611.

The authors declare that there are no conflicts of interest present.