akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.763akusherstvo-2812Research ArticleREVIEW ARTICLEНАУЧНЫЙ ОБЗОРFrom deep infiltrating endometriosis to endometriosis-associated cancer: current aspects of differential diagnosisОт глубокого инфильтративного эндометриоза к эндометриоз-ассоциированному раку: современные аспекты дифференциальной диагностикиhttps://orcid.org/0000-0002-7456-2386СолоповаА. Г.SolopovaA. G.

Солопова Антонина Григорьевна, д.м.н., проф.

Scopus Author ID: 6505479504.

WoS ResearcherID: Q-1385-2015.

119048 Москва, ул. Трубецкая, д. 8, стр. 2 

Antonina G. Solopova, MD, Dr Sci Med, Prof. 

Scopus Author ID: 6505479504.

WoS ResearcherID: Q-1385-2015.

8 bldg. 2, Trubetskaya Str., Moscow 119048

antoninasolopova@yandex.ruhttps://orcid.org/0009-0006-6018-4667ШатилинаА. Ю.ShatilinaA. Yu.

Шатилина Анастасия Юрьевна

119048 Москва, ул. Трубецкая, д. 8, стр. 2 

Anastasia Yu. Shatilina

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0009-0004-9638-7111МартиросянН. А.MartirosyanN. A.

Мартиросян Наира Анатольевна

119048 Москва, ул. Трубецкая, д. 8, стр. 2 

Naira A. Martirosyan

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0009-0004-6618-9456ХадановичМ. Р.KhadanovichM. R.

Хаданович Маргарита Руслановна

119048 Москва, ул. Трубецкая, д. 8, стр. 2 

Margarita R. Khadanovich

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0002-7756-8935ГригорьеваК. Н.GrigorevaK. N.

Григорьева Кристина Николаевна, к.м.н.

119048 Москва, ул. Трубецкая, д. 8, стр. 2 

Kristina N. Grigoreva, MD, PhD

8 bldg. 2, Trubetskaya Str., Moscow 119048

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian Federation20201505202600Online First2812Copyright © Solopova A.G., Shatilina A.Y., Martirosyan N.A., Khadanovich M.R., Grigoreva K.N., 20202020Солопова А.Г., Шатилина А.Ю., Мартиросян Н.А., Хаданович М.Р., Григорьева К.Н.Solopova A.G., Shatilina A.Y., Martirosyan N.A., Khadanovich M.R., Grigoreva K.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2812

Deep infiltrating endometriosis (DIE) is a socially significant condition that markedly reduces patients’ quality of life due to chronic pain syndrome and a high risk of infertility. In recent years, increasing evidence has emerged regarding the malignant transformation of the disease, with the malignant foci developing predominantly in the ovaries, as well as in extra-ovarian locations. The similarity of clinical manifestations, morphological characteristics, and molecular alterations between benign and malignant disease forms markedly complicates differential diagnosis. This article summarizes current concepts regarding the criteria for distinguishing deep infiltrating endometriosis from endometriosis-associated cancer. It highlights the limited evidence base and the need to develop standardized integrative approaches to improve diagnostic accuracy and stratification of oncological risk in this group of patients.

Глубокий инфильтративный эндометриоз является социально значимой проблемой, значительно ухудшающей качество жизни пациенток вследствие хронического болевого синдрома и высокого риска бесплодия. В последнее время все чаще появляются данные о злокачественной трансформации заболевания с формированием очагов малигнизации преимущественно яичниковой, а также внеяичниковой локализации. Сходство клинических проявлений, морфологических характеристик и молекулярных изменений доброкачественных и злокачественных форм существенно затрудняет дифференциальную диагностику. В статье обобщены современные представления о критериях разграничения глубокого инфильтративного эндометриоза и эндометриоз-ассоциированного рака. Подчеркивается ограниченность доказательной базы и необходимость разработки стандартизированных интегративных подходов для повышения точности диагностики и стратификации онкологического риска в данной категории пациенток.

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The authors declare that there are no conflicts of interest present.