This work presents the relevance of the researches associated with the severity of gestosis (pre-eclampsia) in the pregnant women. The importance of the violation of the mechanisms of adaptation (the predominance of catatoxic adaptation programs above syntoxic) and the principles of formation of placental insufficiency are demonstrated. The number of specific pregnancy proteins, leading to insufficient activation of adaptation programs is reduced and activity of adrenal-reactive structures is increased. The purpose was to study psycho-neural and immunologic mechanisms of formation of pre-eclampsia. The authors carried laboratory and instrumental examination of 100 women of fertile age (80 - with pre-eclampsia; 20 - without pathology of pregnancy, which were the control group). Personal and reactive anxiety were examined and applied the techniques of catatimic experiences of images and etc. using imaginations by method of Ericksonian hypnosis. The indicators of systems coagulation-anticoagulative, oxidant and antioxidant activity, immune-suppression and immune-activation, sympathetic and parasympathetic systems were studied in detail. The significance of the decrease in the production of specific pregnancy proteins in the development of placental insufficiency, and catatoxic adaptation programs in the pre-eclampsia is proved. The authors established the importance of study psycho-neural and immunologic correlations, corresponding to the dynamics of adaptation programs.