akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.710akusherstvo-2742Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫImpact of placental angiogenesis disorders and maternal metabolomic profile on pregnancy course and outcomesВлияние нарушений плацентарного ангиогенеза и метаболомного профиля матери на течение и исходы беременностиhttps://orcid.org/0009-0006-9220-3260ГавриловаВ. С.GavrilovaV. S.

Гаврилова Вероника Сергеевна

295007 Симферополь, проспект Академика Вернадского, д. 4

Veronika S. Gavrilova

4 Academician Vernadsky Avenue, Simferopol 295007

gavrvera20@yandex.ruhttps://orcid.org/0009-0005-4520-6461ФоменкоС. Ю.FomenkoS. Yu.

Фоменко София Юрьевна 

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Sofia Yu. Fomenko

29 Nakhichevansky Lane, Rostov-on-Don 344022

https://orcid.org/0009-0002-1922-6520КалашниковаС. А.KalashnikovaS. A.

Калашникова София Андреевна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Sofia A. Kalashnikova

29 Nakhichevansky Lane, Rostov-on-Don 344022

https://orcid.org/0009-0006-7668-595XШебаршеваС. С.ShebarshevaS. S.

Шебаршева Софья Сергеевна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Sofya S. Shebarsheva

29 Nakhichevansky Lane, Rostov-on-Don 344022

https://orcid.org/0009-0004-7560-3647КуделинаЕ. А.KudelinaE. A.

Куделина Елена Алексеевна

191015 Санкт-Петербург, Кирочная ул., д. 41

Elena A. Kudelina

41 Kirochnaya Str., Saint Petersburg 191015

https://orcid.org/0009-0006-7945-8402БородинаГ. В.BorodinaG. V.

Бородина Галия Вячеславовна

191015 Санкт-Петербург, Кирочная ул., д. 41

Galiya V. Borodina

41 Kirochnaya Str., Saint Petersburg 191015

https://orcid.org/0009-0009-6284-2610ГейдароваМ. М.GeydarovaM. M.

Гейдарова Мадина Микаиловна

191015 Санкт-Петербург, Кирочная ул., д. 41

Madina M. Geydarova

41 Kirochnaya Str., Saint Petersburg 191015

https://orcid.org/0009-0008-2529-9535ЛиС. Н.LiS. N.

Ли Светлана Николаевна

191015 Санкт-Петербург, Кирочная ул., д. 41

Svetlana N. Li

41 Kirochnaya Str., Saint Petersburg 191015

https://orcid.org/0009-0009-2666-6760ЩербаковаЕ. А.ShcherbakovaE. A.

Щербакова Екатерина Артуровна

610027 Киров, Владимирская ул., д. 112

Ekaterina A. Shcherbakova

112 Vladimirskaya Str., Kirov 610027

https://orcid.org/0009-0009-4104-5639АниховскаяЗ. А.AnikhovskayaZ. A.

Аниховская Злата Александровна

610027 Киров, Владимирская ул., д. 112

Zlata A. Anikhovskaya

112 Vladimirskaya Str., Kirov 610027

https://orcid.org/0009-0003-2669-8531ФедороваА. А.FedorovaA. A.

Федорова Анастасия Анатольевна

350063 Краснодар, ул. имени Митрофана Седина, д. 4

Anastasia A. Fedorova

4 Mitrofana Sedina Str., Krasnodar 350063

https://orcid.org/0009-0003-0823-6069ОхватН. А.OkhvatN. A.

Охват Надежда Андреевна

350063 Краснодар, ул. имени Митрофана Седина, д. 4

Nadezhda A. Okhvat

4 Mitrofana Sedina Str., Krasnodar 350063

ФГАОУ ВО «Крымский федеральный университет имени В.И. Вернадского»РоссияVernadsky Crimean Federal UniversityRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Министерства здравоохранения Российской ФедерацииРоссияMechnikov North-Western State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Кировский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKirov State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKuban State Medical University, Ministry of Health of the Russian FederationRussian Federation202610052026202303324Copyright © Gavrilova V.S., Fomenko S.Y., Kalashnikova S.A., Shebarsheva S.S., Kudelina E.A., Borodina G.V., Geydarova M.M., Li S.N., Shcherbakova E.A., Anikhovskaya Z.A., Fedorova A.A., Okhvat N.A., 20262026Гаврилова В.С., Фоменко С.Ю., Калашникова С.А., Шебаршева С.С., Куделина Е.А., Бородина Г.В., Гейдарова М.М., Ли С.Н., Щербакова Е.А., Аниховская З.А., Федорова А.А., Охват Н.А.Gavrilova V.S., Fomenko S.Y., Kalashnikova S.A., Shebarsheva S.S., Kudelina E.A., Borodina G.V., Geydarova M.M., Li S.N., Shcherbakova E.A., Anikhovskaya Z.A., Fedorova A.A., Okhvat N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2742Introduction

Introduction. A favorable pregnancy outcome is determined by normally functioning fetoplacental complex. Complications such as preeclampsia (РЕ) and fetal growth restriction (FGR) are associated with disturbed placental angiogenesis and systemic changes in maternal metabolism posing a risk of perinatal pathology.

Aim

Aim: to systematize data regarding a relationship between disorders of placental angiogenesis and alterations in the maternal metabolomic profile, substantiating their combined impact on developing pregnancy complications.

Results

Results. An imbalanced angiogenic factors is a central pathogenetic mechanism that includes: increased soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased placental growth factor (PlGF) level. This leads to endothelial dysfunction, oxidative stress, and systemic inflammation. Metabolomics analysis reveals specific shifts: in РЕ – disturbed phospholipid and amino acid metabolism (arginine, isoleucine); in FGR – altered amino acid and energy metabolism; in gestational diabetes mellitus – early changes in lipid profile and acylcarnitines. These metabolic disturbances often precede clinical manifestation. Combined multi-marker panels, incorporating angiogenic and metabolic biomarkers, demonstrate superior diagnostic and prognostic accuracy compared to individual markers.

Conclusion

Conclusion. Integrative assessment of angiogenic and metabolic markers lays a foundation for early preclinical diagnosis, risk stratification, and the development of targeted therapeutic strategies. Implementing multi-marker panels into clinical practice can markedly improve quality of pregnancy monitoring, prediction of pregnancy outcomes, and ensure timely intervention.

Введение

Введение. Благоприятный исход беременности определяется нормальной функцией фетоплацентарного комплекса. Такие осложнения, как преэклампсия (ПЭ) и задержка роста плода (ЗРП) ассоциированы с нарушениями плацентарного ангиогенеза и системными изменениями метаболизма матери, что формирует риск перинатальной патологии.

Цель

Цель: систематизировать данные о взаимосвязи нарушений плацентарного ангиогенеза и изменений метаболомного профиля матери, обосновав их совокупное влияние на развитие осложнений беременности.

Результаты

Результаты. Центральным звеном патогенеза является дисбаланс ангиогенных факторов: повышение растворимой fms-подобной тирозинкиназы-1 (англ. soluble fms-like tyrosine kinase-1, sFlt-1) и снижение плацентарного фактора роста (англ. placental growth factor, PlGF). Это приводит к эндотелиальной дисфункции, оксидативному стрессу и системному воспалению. Метаболомный анализ выявляет специфические сдвиги: при ПЭ – нарушения метаболизма фосфолипидов и аминокислот (аргинина, изолейцина), при ЗРП – изменения аминокислотного и энергетического обмена, при гестационном сахарном диабете – ранние изменения липидного профиля и ацилкарнитинов. Данные метаболические нарушения часто предшествуют клинической манифестации. Комбинированные мультимаркерные панели, включающие ангиогенные и метаболические биомаркеры, демонстрируют более высокую диагностическую и прогностическую точность по сравнению с отдельными маркерами.

Заключение

Заключение. Интегративная оценка ангиогенных и метаболических маркеров создает основу для ранней доклинической диагностики, стратификации риска и разработки таргетных терапевтических стратегий. Внедрение мультимаркерных панелей в клиническую практику может значительно повысить качество мониторинга беременности, прогнозирование исходов беременности и обеспечить своевременную коррекцию.

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The authors declare that there are no conflicts of interest present.