akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2026.725akusherstvo-2715Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫAmniotic fluid embolism as an immunocoagulatory catastrophic anaphylactoid syndromeЭмболия околоплодными водами как иммунокоагуляционный катастрофический анафилактоидный синдромhttps://orcid.org/0009-0006-1782-1966ОсколковаА. Р.OskolkovaA. R.

Осколкова Арина Романовна

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Arina R. Oskolkova

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0009-0003-5190-4958ХисамиеваА. Р.KhisamievaA. R.

Хисамиева Азалия Рустемовна

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Azaliia R. Khisamieva

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0001-8404-1042БицадзеВ. О.BitsadzeV. O.

Бицадзе Виктория Омаровна - д.м.н., проф., профессор РАН.

Scopus Author ID: 6506003478

WoS ResearcherID: F-8409-2017

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Victoria O. Bitsadze - MD, Dr Sci Med, Prof., Professor of RAS.

Scopus Author ID: 6506003478

WoS ResearcherID: F-8409-2017

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0002-0725-9686ХизроеваД. Х.KhizroevaJ. Kh.

Хизроева Джамиля Хизриевна - д.м.н., проф.

Scopus Author ID: 57194547147

WoS ResearcherID: F-8384-2017

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Jamilya Kh. Khizroeva - MD, Dr Sci Med, Prof.

Scopus Author ID: 57194547147

WoS ResearcherID: F-8384-2017

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0002-2541-3843МакацарияН. А.MakatsariyaN. A.

Макацария Наталия Александровна - к.м.н.

WoS ResearcherID: F-8406-2017

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Nataliya A. Makatsariya - MD, PhD.

WoS ResearcherID: F-84062017

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0002-3628-0804ТретьяковаМ. В.TretyakovaM. V.

Третьякова Мария Владимировна - к.м.н.

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Maria V. Tretyakova - MD, PhD.

8 bldg. 2, Trubetskaya Str., Moscow 119048

https://orcid.org/0000-0003-0764-4477ГашимоваН. Р.GashimovaN. R.

Гашимова Нилуфар Рамиль кызы - к.м.н.

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Nilufar R. Gashimova - MD, PhD.

8 bldg. 2, Trubetskaya Str., Moscow 119048

nelya.94@yandex.ruhttps://orcid.org/0000-0002-7756-8935ГригорьеваК. Н.GrigorevaK. N.

Григорьева Кристина Николаевна - к.м.н.

119048 Москва, ул. Трубецкая, д. 8, стр. 2; Франция, 34090 Монпелье, ул. Огюста Бруссоне, д. 163

Kristina N. Grigoreva - MD, PhD.

8 bldg. 2, Trubetskaya Str., Moscow 119048

ПанфиловаО. Ю.PanfilovaO. Yu.

Панфилова Ольга Юрьевна, к.м.н.

129110 Москва, ул. Щепкина, д. 35

Olga Yu. Panfilova - MD, PhD.

35 Shchepkina Str., Moscow 129110

https://orcid.org/0000-0002-9899-9910ГриЖ.-К.GrisJ.-Ch.

Гри Жан-Кристоф - д.м.н., проф., иностранный член РАН.

Scopus Author ID: 7005114260

WoS ResearcherID: AAA-2923-2019

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Jean-Christophe Gris - MD, Dr Sci Med, Prof., Foreign Member of RAS.

Scopus Author ID: 7005114260

WoS ResearcherID: AAA-2923-2019

8 bldg. 2, Trubetskaya Str., Moscow 119048; 163 Rue Auguste Broussonnet, Montpellier 34090

https://orcid.org/0000-0002-9576-1368ЭлаламиИ.ElalamyI.

Элалами Исмаил - д.м.н., проф., иностранный член РАН.

Scopus Author ID: 7003652413

WoS ResearcherID: AAC-9695-2019

119048 Москва, ул. Трубецкая, д. 8, стр. 2; Марокко, 42312 Марракеш, шоссе Амизмиз, 13-й км; 92200 Париж, Neuilly-sur-Seine, улица дю Шато, д. 55

Ismail Elalamy - MD, Dr Sci Med, Prof., Foreign Member of RAS.

Scopus Author ID: 7003652413

WoS ResearcherID: AAC-9695-2019

8 bldg. 2, Trubetskaya Str., Moscow 119048; Km 13, Route d’Amizmiz, Marrakech 42312, Morocco; 55 Rue du Châtea; Neuilly-sur-Seine, Paris 92200

https://orcid.org/0000-0003-2316-6348ГеротзиафасГ.GerotziafasG.

Геротзиафас Григориос - д.м.н., проф., иностранный член РАН.

119048 Москва, ул. Трубецкая, д. 8, стр. 2; 75020 Париж, Китайская улица, д. 4; 75013 Париж, Бульвар Госпитале, д. 91; 75012 Париж, улица дю Фобур Сен-Антуан, д. 184

Grigoriоs Gerotziafas - MD, Dr Sci Med, Prof., Foreign Member of RAS.

8 bldg. 2, Trubetskaya Str., Moscow 119048; 4 Rue de la Chine, 75020 Paris; 91 Boulevard de l'Hôpital, 75013 Paris; 34 Rue du Crozatier, F-75012 Paris

https://orcid.org/0000-0001-7415-4633МакацарияА. Д.MakatsariyaE. D.

Макацария Александр Давидович - д.м.н., проф., академик РАН.

Scopus Author ID: 57222220144

WoS ResearcherID: M-5660-2016

119048 Москва, ул. Трубецкая, д. 8, стр. 2

Alexander D. Makatsariya - MD, Dr Sci Med, Prof., Academician of RAS.

Scopus Author ID: 57222220144

WoS ResearcherID: M-5660-2016

8 bldg. 2, Trubetskaya Str., Moscow 119048

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationАО «Европейский Медицинский Центр»РоссияJSC European Medical CenterRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Университет МонпельеРоссияSechenov University; University of MontpellierRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Частный университет Марракеша; Американский госпиталь ПарижаФранцияSechenov University; Université Privée de Marrakech; Hopital Americain de ParisFranceФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Госпиталь Тенон, Университетский институт онкологии AP-HP, Университет Сорбонна; Медицинский факультет Сорбонского университета; Университетская больница Сен-Антуан, Университетский институт онкологии AP-HP, Университет СорбоннаФранцияSechenov University; Tenon Hospital, Hôpitaux Universitaires Est Parisien, Assistance Publique Hôpitaux de Paris (AP-HP), France; Faculty of Medicine Sorbonne University; Saint-Antoine Research Center (CRSA), University Institute of Cancerology (UIC)France202612032026201177191Copyright © Oskolkova A.R., Khisamieva A.R., Bitsadze V.O., Khizroeva J.K., Makatsariya N.A., Tretyakova M.V., Gashimova N.R., Grigoreva K.N., Panfilova O.Y., Gris J., Elalamy I., Gerotziafas G., Makatsariya E.D., 20262026Осколкова А.Р., Хисамиева А.Р., Бицадзе В.О., Хизроева Д.Х., Макацария Н.А., Третьякова М.В., Гашимова Н.Р., Григорьева К.Н., Панфилова О.Ю., Гри Ж., Элалами И., Геротзиафас Г., Макацария А.Д.Oskolkova A.R., Khisamieva A.R., Bitsadze V.O., Khizroeva J.K., Makatsariya N.A., Tretyakova M.V., Gashimova N.R., Grigoreva K.N., Panfilova O.Y., Gris J., Elalamy I., Gerotziafas G., Makatsariya E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2715

Amniotic fluid embolism (AFE) is a rare, life-threatening obstetric complication, known in modern terminology as anaphylactoid syndrome of pregnancy (ASP). ASP is an acute reaction triggered by the penetration of amniotic fluid (containing fetal cells, meconium, tissue factor, etc.) into the maternal circulatory system. This leads to a cascade of pathological reactions comprising the classic triad of fetal hypoxia: acute hypoxia (dyspnea, cyanosis), circulatory collapse (shock, cardiac arrest), and coagulopathy (bleeding). Fetal hypoxia is a diagnosis of exclusion; its treatment is aimed at combating the three main threats: respiratory failure, hemodynamic collapse, and coagulopathy. The prognosis is extremely grave, with maternal mortality reaching 80–90 %. Perinatal mortality and morbidity are also very high due to acute fetal hypoxia. ASP remains one of the most dangerous and poorly predicted causes of maternal mortality. A high level of physician vigilance, awareness of early symptoms, and immediate initiation of comprehensive resuscitation and intensive care aimed at maintaining oxygenation, hemodynamics, and correcting coagulopathy are crucial. The modern therapeutic approach to the syndrome as an anaphylactoid reaction justifies the use of high glucocorticosteroid doses.

Эмболия околоплодными водами (ЭОВ) – это редкое, жизнеугрожающее акушерское осложнение, в современной терминологии именуемое анафилактоидным синдромом беременности (АСБ). АСБ – острая реакция, запускаемая проникновением амниотической жидкости (содержащей клетки плода, меконий, тканевый фактор и др.) в материнскую кровеносную систему. Это приводит к каскаду патологических реакций, составляющих классическую триаду АСБ: острая гипоксия (одышка, цианоз), циркуляторный коллапс (шок, остановка сердца) и коагулопатия (кровотечение). АСБ является диагнозом исключения, его лечение направлено на борьбу с тремя главными угрозами: дыхательная недостаточность, гемодинамический коллапс и коагулопатия. Прогноз крайне серьезный, материнская смертность достигает 80–90 %. Перинатальная смертность и заболеваемость также очень высоки из-за острой гипоксии плода. АСБ остается одной из самых опасных и плохо предсказуемых причин материнской смертности. Ключевое значение имеют высокая настороженность врачей, знание ранних симптомов, немедленное начало комплексной реанимации и интенсивной терапии, направленной на поддержание оксигенации, гемодинамики и коррекцию коагулопатии. Современный подход к синдрому как к анафилактоидной реакции обосновывает использование в терапии высоких доз глюкокортикостероидов.

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The authors declare that there are no conflicts of interest present.