akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2025.658akusherstvo-2520Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫOvarian toxicity of endocrine-disrupting chemicals: current state of the problemОвариальная токсичность эндокринных дизрапторов: современное состояние проблемыhttps://orcid.org/0009-0009-0617-7097КоломыцеваЛ. Н.KolomytsevaL. N.

Коломыцева Людмила Николаевна

350063 Краснодар, ул. Митрофана Седина, д. 4

Lyudmila N. Kolomytseva

4 Mitrofana Sedina Str., Krasnodar 350063

lkolomyceva819@gmail.comhttps://orcid.org/0009-0004-3878-2076НебораЕ. Д.NeboraE. D.

Небора Елизавета Денисовна

394036 Воронеж, ул. Студенческая, д. 10

Elizaveta D. Nebora

10 Studentskaya Str., Voronezh 394036

https://orcid.org/0009-0005-8157-1327ДжамалутиновА. Д.DzhamalutinovA. D.

Джамалутинов Али Джамалутинович

450008 Уфа, ул. Ленина, д. 3

Ali D. Dzhamalutinov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0004-3516-6307СуфияровД. И.SufiyarovD. I.

Суфияров Дамир Ильдарович

450008 Уфа, ул. Ленина, д. 3

Damir I. Sufiyarov

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0000-2875-8030МугиноваД. Р.MuginovaD. R.

Мугинова Дина Руслановна

450008 Уфа, ул. Ленина, д. 3

Dina R. Muginova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0006-3577-3224МуллагуловаИ. И.MullagulovaI. I.

Муллагулова Илина Ильнуровна

450008 Уфа, ул. Ленина, д. 3

Ilina I. Mullagulova

3 Lenin Str., Ufa 450008

https://orcid.org/0009-0009-7672-2417ТушиговА. С.TushigovA. S.

Тушигов Аюб Супьянович

355017 Ставрополь, ул. Мира, д. 310

Ayub S. Tushigov

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0007-0176-508XБазароваЗ. Д.BazarovaZ. D.

Базарова Заира Джанмухаметовна

355017 Ставрополь, ул. Мира, д. 310

Zaira D. Bazarova

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0009-8205-1349НосинковаТ. А.NosinkovaT. A.

Носинкова Татьяна Александровна

355017 Ставрополь, ул. Мира, д. 310

Tatyana A. Nosinkova

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0008-9771-8102ХусейноваЛ. А.KhuseynovaL. A.

Хусейнова Луиза Арсланбековна

355017 Ставрополь, ул. Мира, д. 310

Luiza A. Khuseynova

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0007-9161-4460ДеревянкоК. А.DerevyankoK. A.

Деревянко Кристина Александровна

355017 Ставрополь, ул. Мира, д. 310

Kristina A. Derevyanko

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0009-2015-5281АбаеваМ. П.AbaevaM. P.

Абаева Максалина Пашаевна

355017 Ставрополь, ул. Мира, д. 310

Maksalina P. Abaeva

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0006-8218-9207МагомедоваЖ. Ж.MagomedovaZh. Zh.

Магомедова Жамиля Жабировна

355017 Ставрополь, ул. Мира, д. 310

Zhamilya Zh. Magomedova

310 Mira Str., Stavropol 355017

https://orcid.org/0009-0000-5133-0294БорлаковаС. М.BorlakovaS. M.

Борлакова Саида Маратовна

355017 Ставрополь, ул. Мира, д. 310

Saida M. Borlakova

310 Mira Str., Stavropol 355017

ФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKuban State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Воронежский государственный медицинский университет имени Н.Н. Бурденко» Министерства здравоохранения Российской ФедерацииРоссияBurdenko Voronezh State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияStavropol State Medical University, Ministry of Health of the Russian FederationRussian Federation202512112025195759775Copyright © Kolomytseva L.N., Nebora E.D., Dzhamalutinov A.D., Sufiyarov D.I., Muginova D.R., Mullagulova I.I., Tushigov A.S., Bazarova Z.D., Nosinkova T.A., Khuseynova L.A., Derevyanko K.A., Abaeva M.P., Magomedova Z.Z., Borlakova S.M., 20252025Коломыцева Л.Н., Небора Е.Д., Джамалутинов А.Д., Суфияров Д.И., Мугинова Д.Р., Муллагулова И.И., Тушигов А.С., Базарова З.Д., Носинкова Т.А., Хусейнова Л.А., Деревянко К.А., Абаева М.П., Магомедова Ж.Ж., Борлакова С.М.Kolomytseva L.N., Nebora E.D., Dzhamalutinov A.D., Sufiyarov D.I., Muginova D.R., Mullagulova I.I., Tushigov A.S., Bazarova Z.D., Nosinkova T.A., Khuseynova L.A., Derevyanko K.A., Abaeva M.P., Magomedova Z.Z., Borlakova S.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2520

Endocrine-disrupting chemicals (EDC) represent a broad class of exogenous substances capable of interfering with the normal functioning of the hormonal system and exerting profound effects on female reproductive health. One of the most vulnerable targets for EDC action are ovaries, where they initiate a cascade of pathophysiological processes. This review systematizes current data on the key mechanisms of EDC-induced ovarian toxicity, including hormonal dysregulation, oxidative stress, apoptosis, epigenetic modifications, and disruption of intercellular signaling. It has been demonstrated that chronic exposure to the agents such as bisphenol A, phthalates, polycyclic aromatic hydrocarbons, and dioxins leads to impaired folliculogenesis, ovarian reserve depletion, and premature ovarian insufficiency. Furthermore, we also discuss epigenetic inheritance mechanisms through which EDC may exert long-term effects on reproductive function across generations. Special attention is paid to therapeutic strategies aimed at mitigating EDC-induced damage, including the use of antioxidants, signaling pathway modulators, and epigenetic regulators. Case studies are presented, which illustrate the global scale of environmental EDC contamination and their bioaccumulation in biological systems. The collective evidence underscors an urgent need for a multidisciplinary approach to risk assessment as well as development of preventive and therapeutic interventions to alleviate EDC impact on women’s reproductive health and to safeguard the reproductive potential of future generations.

Химические вещества, разрушающие эндокринную систему (англ. endocrine-disrupting chemicals, EDC), представляют собой широкий спектр экзогенных веществ, способных нарушать нормальное функционирование гормональной системы и вызывать серьезные последствия для женского репродуктивного здоровья. Одной из наиболее уязвимых мишеней для действия EDC являются яичники, в которых они запускают ряд патофизиологических процессов. В настоящей статье систематизированы современные данные о ключевых механизмах овариальной токсичности, индуцированной EDC, включая нарушение гормональной регуляции, окислительный стресс, апоптоз, эпигенетические модификации и нарушение межклеточной сигнализации. Показано, что хроническое воздействие таких соединений, как бисфенол А, фталаты, полициклические ароматические углеводороды и диоксины, приводит к нарушению фолликулогенеза, истощению овариального резерва и преждевременной недостаточности яичников. Кроме того, обсуждаются механизмы эпигенетического наследования, через которые EDC могут оказывать долговременное влияние на репродуктивную функцию нескольких поколений. Особое внимание уделено терапевтическим стратегиям, включая использование антиоксидантов, модуляторов сигнальных путей и эпигенетических регуляторов, направленных на смягчение токсических эффектов EDC. Приведены тематические исследования, демонстрирующие глобальное распространение загрязнения окружающей среды EDC и их биоаккумуляцию в биологических объектах. Полученные данные подчеркивают необходимость междисциплинарного подхода к оценке рисков и разработки профилактических и лечебных мер, направленных на снижение влияния EDC на репродуктивное здоровье женщин и охрану репродуктивного потенциала будущих поколений.

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The authors declare that there are no conflicts of interest present.