akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2025.635akusherstvo-2505Research ArticleCLINICAL CASESКЛИНИЧЕСКИЕ СЛУЧАИCongenital human herpesvirus 6 infection in a full-term newborn: literature review and case reportВрожденная инфекция у доношенного новорожденного ребенка, вызванная вирусом герпеса человека 6-го типа: обзор литературы и клинический случайhttps://orcid.org/0000-0002-1024-0230КарповаА. Л.KarpovaA. L.

Карпова Анна Львовна - к.м.н. Scopus Author ID: 57197280474.

123423 Москва, ул. Саляма Адиля, д. 2/44; 123995 Москва, ул. Баррикадная, д. 2/1, корп. 1; 150000 Ярославль, ул. Революционная, д. 5

Anna L. Karpova - MD, PhD. Scopus Author ID: 57197280474.

2/44 Salyama Adilya Str., Moscow 123423; 2/1 bldg. 1, Barrikadnaya Str., Moscow 123993; 5 Revolutsionnaya Str., Yaroslavl 150000

https://orcid.org/0000-0002-7040-9683МостовойА. В.MostovoiA. V.

Мостовой Алексей Валерьевич - к.м.н. Scopus Author ID: 57201723894. Wos ResearcherID: AAR-7908-2021.

123423 Москва, ул. Саляма Адиля, д. 2/44; 123995 Москва, ул. Баррикадная, д. 2/1, корп. 1; 150000 Ярославль, ул. Революционная, д. 5

Aleksei V. Mostovoi - MD, PhD. Scopus Author ID: 57201723894. Wos ResearcherID: AAR-7908-2021.

2/44 Salyama Adilya Str., Moscow 123423; 2/1 bldg. 1, Barrikadnaya Str., Moscow 123993; 5 Revolutsionnaya Str., Yaroslavl 150000

valmost@mail.ruhttps://orcid.org/0000-0001-7847-1679БарановА. А.BaranovA. A.

Баранов Андрей Анатольевич - д.м.н., проф. Scopus Author ID: 7201565006.

150000 Ярославль, ул. Революционная, д. 5

Andrey A. Baranov - MD, Dr Sci Med, Prof. Scopus Author ID: 7201565006.

5 Revolutsionnaya Str., Yaroslavl 150000

https://orcid.org/0009-0001-0210-4669АникееваЛ. А.AnikeevaL. A.

Аникеева Любовь Алексеевна

123423 Москва, ул. Саляма Адиля, д. 2/44

Lyubov A. Anikeeva - MD.

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0009-0008-2222-2604КлубничкинаЕ. В.KlubnichkinaE. V.

Клубничкина Екатерина Васильевна 

123423 Москва, ул. Саляма Адиля, д. 2/44

Ekaterina V. Klubnichkina - MD.

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0003-1303-8318ЗаплатниковА. Л.ZaplatnikovA. L.

Заплатников Андрей Леонидович - д.м.н., проф.

123995 Москва, ул. Баррикадная, д. 2/1, корп. 1

Andrey L. Zaplatnikov - MD, Dr Sci Med, Prof.

2/1 bldg. 1, Barrikadnaya Str., Moscow 123993

https://orcid.org/0000-0003-4252-4390КарповЛ. Н.KarpovL. N.

Карпов Леонид Николаевич

121552 Москва, Рублевское шоссе, д. 135

Leonid N. Karpov - MD.

135 Rublevskoe Shosse, Moscow 121552

ГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации; ФГБОУ ВО «Ярославский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation; Yaroslavl State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Ярославский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияYaroslavl State Medical University, Ministry of Health of the Russian FederationRussian FederationГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»РоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииРоссияRussian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева» Министерства здравоохранения Российской ФедерацииРоссияBakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health of the Russian FederationRussian Federation202512112025195801811Copyright © Karpova A.L., Mostovoi A.V., Baranov A.A., Anikeeva L.A., Klubnichkina E.V., Zaplatnikov A.L., Karpov L.N., 20252025Карпова А.Л., Мостовой А.В., Баранов А.А., Аникеева Л.А., Клубничкина Е.В., Заплатников А.Л., Карпов Л.Н.Karpova A.L., Mostovoi A.V., Baranov A.A., Anikeeva L.A., Klubnichkina E.V., Zaplatnikov A.L., Karpov L.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2505

Neonatal human herpesvirus type 6 (HHV-6) infection is an extremely rare disease. HHV-6 is a unique virus because it is able to integrate into human chromosomes to be further transmitted vertically from parent to offspring. In humans, HHV-6 is associated with a wide range of clinical manifestations and, in children, may present as roseola infantum, febrile seizures, aphthous stomatitis, mononucleosis-like syndrome, or fever of unknown origin. This article reports a rare case of congenital HHV-6 infection in a newborn. To date, both Russian and international publications provide very limited descriptions of such cases, which, in our opinion, reflects a significant knowledge gap among neonatologists regarding this condition. We discuss the clinical forms of HHV-6 infection in neonates, rare case presentations, and current approaches to diagnosis and treatment.

Инфекция, вызванная вирусом герпеса человека 6-го типа (ВГЧ-6) у новорожденных детей, встречается крайне редко. Уникальность ВГЧ-6 заключается в том, что это единственный вирус, который интегрируется в хромосомы человека и передается от родителей к потомству. ВГЧ-6 у человека может быть связан с широким спектром заболеваний, а у детей нередко протекает с развитием внезапной экзантемы, фебрильных приступов, афтозного стоматита, мононуклеозоподобного синдрома или лихорадки без очага инфекции. Предлагаем описание редкого клинического наблюдения врожденной инфекции ВГЧ-6 у новорожденного ребенка, поскольку описаний таких случаев как в отечественной, так и в зарубежной литературе крайне мало, что отражает, по нашему мнению, значительные пробелы в знаниях врачей-неонатологов в данном вопросе. Обсуждаются формы течения заболевания, редкие клинические наблюдения, а также методы диагностики и терапии ВГЧ-6.

изоляты типа А и В вируса герпеса человека 6-го типаВГЧ-6новорожденныйвирусный энцефалитпротивовирусная терапияhuman herpesvirus type 6 variants A and BHHV-6newbornviral encephalitisantiviral therapyАвторы заявляют об отсутствии финансирования. Авторы благодарят научного сотрудника ФГБУ НИЦ эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи Минздрава России Башьяна Романа Евгеньевича и врача-инфекциониста ГБУЗ ГКБ № 67 им. Л.А. Ворохобова ДЗМ Погосяна Ашота Григорьевича за помощь в подготовке данного материала.The authors declare no funding. The authors express gratitude to Roman E. Bashyan, Research Fellow at the Gamaleya National Research Center for Epidemiology and Microbiology, and to Ashot G. Pogosyan, Infectious Disease Specialist at Vorokhobov City Clinical Hospital No. 67 for their assistance in manuscript preparationReferencesМелёхина Е.В., Музыка А.Д., Калугина М.Ю. и др. Современные представления об инфекции, вызванной вирусом герпеса человека 6 типа. 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The authors declare that there are no conflicts of interest present.