Planning of a family and preservation of reproductive health - the important problem of modern medicine. According to recommendations the CART (1994) contraception is recommended to women up to menopaysa and absence menses in a current of year. In a kind of high risk of development or aggravation metabolic and hemostasies infringements for the purpose of hormonal contraception at women late reproductive period and perimenopaysa we had been used the microdosed out preparation Miniziston®20 Fem, containing 0,02 mg etynilestradiol and 0,1 mg levonorgestrel. Results of our research have shown that the given preparation has 100% contraceptive efficiency, provides necessary regulation of menstryal cycle, presence estrogen component promotes improvement of quality of a life of patients and knocking over of clinical symptoms, characteristic for the period perimenopaysa. Besides, Miniziston®20 Fem does not render clinically significant influence on metabolic an exchange and hemostasis system.