akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2025.632akusherstvo-2430Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫSystematic computer analysis of iron fumarate pharmacology in the treatment of iron deficiency and iron deficiency anemiaСистематический компьютерный анализ фармакологии фумарата железа в контексте лечения дефицита железа и железодефицитной анемииhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна, д.м.н., проф.

Scopus Author ID: 7003589812

WoS ResearcherID: J-4946-2017

119333 Москва, ул. Вавилова, д. 44, корп. 2

Olga A. Gromova, MD, Dr Sci Med, Prof.

Scopus Author ID: 7003589812

WoS ResearcherID: J-4946-2017

44 bldg. 2, Vavilova Str., Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич, к.ф-м.н., к.х.н.

Scopus Author ID: 7003300274

WoS ResearcherID: C-7683-2018

119333 Москва, ул. Вавилова, д. 44, корп. 2

Ivan Yu. Torshin, MD, PhD in Applied Mathematics, PhD in Chemistry

Scopus Author ID: 7003300274

WoS ResearcherID: C-7683-2018

44 bldg. 2, Vavilova Str., Moscow 119333

https://orcid.org/0000-0002-9201-2281ТетруашвилиН. К.TetruashviliN. K.

Тетруашвили Нана Картлосовна, д.м.н., проф.

117997 Москва, ул. Академика Опарина, д. 4

Nana K. Tetruashvili, MD, Dr Sci Med, Prof.

4 Academician Oparin Str., Moscow 117997

ФГУ «Федеральный исследовательский центр "Информатика и управление" Российской академии наук»РоссияFederal Research Center "Computer Science and Control", Russian Academy of SciencesRussian FederationФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияAcademician Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian FederationRussian Federation202510052025192230249Copyright © Gromova O.A., Torshin I.Y., Tetruashvili N.K., 20252025Громова О.А., Торшин И.Ю., Тетруашвили Н.К.Gromova O.A., Torshin I.Y., Tetruashvili N.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2430Introduction

Introduction. The use of the safest and most effective methods for iron deficiency (ID) compensation is implicated in current therapy of iron deficiency anemia (IDA). Oral administration of iron salts with organic acid anions is an important field in IDA therapy and prevention. Iron fumarate, being a divalent iron salt and the fumaric acid anion (a tricarboxylic acid cycle metabolite), is absorbed in vivo via gene-encoded molecular mechanisms specialized to interact primarily with fumarate anion.

Aim

Aim: to systematize the data from fundamental and clinical studies on iron fumarate pharmacology for ID treatment using topological and metric methods of intellectual analysis.

Results

Results. The results of systematization of studies on iron fumarate pharmacology (more than 500 articles) are presented along and performed categorization of all available publications. The results of the most essential research fields assessing iron fumarate pharmacology are described in detail: (1) comparative pharmacology of iron fumarate and other iron forms; (2) an effect of various iron salts on tissue hemosiderosis; (3) synergism between iron fumarate and folates and other micronutrients; (4) an effect of microbiome state and iron fumarate absorption improved by prebiotics; (5) clinical practice of using iron fumarate for IDA treatment of women in all age groups.

Conclusion

Conclusion. Fumarate-containing preparations are indicated in case where profound substrate-mediated support is required for pillar arms of aerobic and anaerobic energy metabolism ranging from mitochondria and cells to organismal level demanding to mobilize signal-regulatory adaptive reactions. Oral intake of fumarate salt preparations may exert milder and safer effect. In aerobic and hypoxic energy metabolism, which is typical for ID, fumarate salts may act as effective anti-stress and anti-hypoxic agents.

Введение

Введение. Современная терапия железодефицитной анемии (ЖДА) предполагает использование наиболее безопасных и эффективных способов компенсации дефицита железа (ДЖ). Важным направлением терапии и профилактики ЖДА является пероральный прием солей железа с анионами органических кислот. Фумарат железа, будучи солью двухвалентного железа и аниона фумаровой кислоты (метаболит цикла Кребса), усваивается в организме посредством кодируемых генами молекулярных механизмов, специализированных для взаимодействий именно с фумарат-анионом.

Цель

Цель: систематизация фундаментальных и клинических исследований о фармакологии фумарата железа для лечения ДЖ с использованием тополого-метрических методов интеллектуального анализа данных.

Результаты

Результаты. Представлены результаты систематизации исследований по фармакологии фумарата железа (более 500 статей), проведена рубрикация всех имеющихся публикаций. Детально описаны результаты наиболее важных направлений исследований фармакологии фумарата железа: (1) сравнительная фармакология фумарата железа и других форм железа; (2) влияние различных солей железа на гемосидероз тканей; (3) синергизм фумарата железа с фолатами и другими микронутриентами; (4) влияние состояние микробиома и улучшение всасывания фумарата железа пребиотиками; (5) клиническая практика применения фумарата железа в терапии ЖДА у женщин всех возрастных групп.

Заключение

Заключение. Фумарат-содержащие препараты показаны в тех условиях, когда требуется весомая субстратная поддержка ключевых звеньев аэробного и анаэробного энергетического обмена на разных уровнях от митохондрий и клеток до целого организма и имеется потребность в мобилизации сигнально-регуляторных адаптивных реакций. Прием препаратов солей фумарата внутрь может оказывать мягкое и более безопасное воздействие. При аэробном и гипоксическом течении энергетического обмена, что характерно для ДЖ, соли фумарата могут проявить себя как эффективные противострессовые и противогипоксические средства.

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The authors declare that there are no conflicts of interest present.