akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2025.607akusherstvo-2387Research ArticleREVIEW ARTICLESНАУЧНЫЕ ОБЗОРЫFertility preservation methods in the context of breast cancer treatment: real-life experience and prospectsМетоды сохранения фертильности в контексте лечения рака молочной железы: реальность и перспективыhttps://orcid.org/0009-0009-5975-4951ЗагидуллинаА. А.ZagidullinaA. A.

Загидуллина Алина Альбертовна 

420012 Казань, ул. Бутлерова, д. 49

Alina A. Zagidullina

49 Butlerova Str., Kazan 420012

alinazagidullina000@mail.ruhttps://orcid.org/0009-0001-8105-7986ДжамбулатоваЛ. А.DzhambulatovaL. A.

Джамбулатова Лалита Алаудиновна

362019 Республика Северная Осетия–Алания, Владикавказ, ул. Пушкинская, д. 40

Lalita A. Dzhambulatova

40 Pushkinskaya Str., Vladikavkaz, Republic of North Ossetia–Alania 362019

https://orcid.org/0009-0004-1748-6251ШатуеваМ. А.ShatuevaM. A.

Шатуева Марьям Асламбековна

362019 Республика Северная Осетия–Алания, Владикавказ, ул. Пушкинская, д. 40

Maryam A. Shatueva

40 Pushkinskaya Str., Vladikavkaz, Republic of North Ossetia–Alania 362019

https://orcid.org/0009-0005-7781-2693ДонгакТ. Б.DongakT. B.

Донгак Тереза Байлаковна

117997 Москва, ул. Островитянова, д. 1

Tereza B. Dongak

1 Ostrovityanova Str., Moscow 117997

https://orcid.org/0009-0009-9815-3892ЛаубахЯ. С.LaubakhY. S.

Лаубах Яна Сергеевна

660022 Красноярск, ул. Партизана Железняка, д. 1

Yana S. Laubakh

1 Partizana Zheleznyaka Str., Krasnoyarsk 660022

https://orcid.org/0009-0000-3011-1367ШакироваД. С.ShakirovaD. S.

Шакирова Диана Сергеевна

350063 Краснодар, ул. Митрофана Седина, д. 4

Diana S. Shakirova

4 Mitrofana Sedina Str., Krasnodar 350063

https://orcid.org/0009-0006-7920-3901ГоланцевА. С.GolantsevA. S.

Голанцев Александр Сергеевич

350063 Краснодар, ул. Митрофана Седина, д. 4

Aleksandr S. Golantsev

4 Mitrofana Sedina Str., Krasnodar 350063

https://orcid.org/0009-0003-9797-5807ПайзулаеваХ. Р.PayzulaevaKh. R.

Пайзулаева Хава Руслановна

362019 Республика Северная Осетия–Алания, Владикавказ, ул. Пушкинская, д. 40

Khava R. Payzulaeva

40 Pushkinskaya Str., Vladikavkaz, Republic of North Ossetia–Alania 362019

https://orcid.org/0009-0002-3147-9571ЯстребоваД. П.YastrebovaD. P.

Ястребова Диана Павловна

191144 Санкт-Петербург, Мытнинская ул., д. 25, лит. А

Diana P. Yastrebova - MD

25 lit. A, Mytninskaya Str., Saint Petersburg 191144

https://orcid.org/0009-0008-7148-3237АксеновА. М.AksenovA. M.

Аксёнов Алексей Михайлович

194100 Санкт-Петербург, ул. Литовская, д. 2

Aleksey M. Aksenov

2 Litovskaya Str., Saint Petersburg 194100

https://orcid.org/0009-0000-7701-0731ГончароваЕ. С.GoncharovaE. S.

Гончарова Елена Сергеевна

350063 Краснодар, ул. Митрофана Седина, д. 4

Elena S. Goncharova

4 Mitrofana Sedina Str., Krasnodar 350063

https://orcid.org/0009-0008-2844-1437ОжерельеваМ. А.OzherelevaM. A.

Ожерельева Мария Александровна

350063 Краснодар, ул. Митрофана Седина, д. 4

Maria A. Ozhereleva

4 Mitrofana Sedina Str., Krasnodar 350063

https://orcid.org/0009-0004-3435-2765СаргсянД. Г.SargsyanD. G.

Саргсян Джульетта Гургеновна

344022 Ростов-на-Дону, Нахичеванский переулок, д. 29

Dzhuletta G. Sargsyan

29 Nakhichevansky Lane, Rostov-on-Don 344022

ФГБОУ ВО «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Северо-Осетинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияNorth Ossetian State Medical Academy, Ministry of Health of the Russian FederationRussian FederationФГАОУ ВО «Российский национальный исследовательный медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияPirogov Russian National Research Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Кубанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKuban State Medical University, Ministry of Health of the Russian FederationRussian FederationСПб ГБУЗ «Детская городская поликлиника № 44»РоссияChildren's City Polyclinic No. 44Russian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет»РоссияSaint Petersburg State Pediatric Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical University, Ministry of Health of the Russian FederationRussian Federation202506072025193389407Copyright © Zagidullina A.A., Dzhambulatova L.A., Shatueva M.A., Dongak T.B., Laubakh Y.S., Shakirova D.S., Golantsev A.S., Payzulaeva K.R., Yastrebova D.P., Aksenov A.M., Goncharova E.S., Ozhereleva M.A., Sargsyan D.G., 20252025Загидуллина А.А., Джамбулатова Л.А., Шатуева М.А., Донгак Т.Б., Лаубах Я.С., Шакирова Д.С., Голанцев А.С., Пайзулаева Х.Р., Ястребова Д.П., Аксенов А.М., Гончарова Е.С., Ожерельева М.А., Саргсян Д.Г.Zagidullina A.A., Dzhambulatova L.A., Shatueva M.A., Dongak T.B., Laubakh Y.S., Shakirova D.S., Golantsev A.S., Payzulaeva K.R., Yastrebova D.P., Aksenov A.M., Goncharova E.S., Ozhereleva M.A., Sargsyan D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2387

The article discusses current methods for preserving fertility in women undergoing breast cancer (BC) treatment. It provides a detailed overview of contemporary breast cancer treatments and their impact on fertility. To prevent fertility loss, there are described key strategies such as oocyte, embryo, and ovarian tissue cryopreservation, as well as temporary suppression of ovarian function using gonadotropin-releasing hormone agonists. In addition, it analyzes factors such as lack of information, limited medical resources, and the need for immediate anticancer therapy initiation that hinder access to such methods. The importance of comprehensive patient support systems involving coordination among oncologists, reproductive specialists, and psychologists is emphasized. Special attention is paid to further development and improvement of existing methods aimed at reducing gonadotoxicity, as well as ongoing research to identify new safe and effective strategies. It is specifically stressed about importance of long-term monitoring of children born from preserved gametes and tissues to assess the safety and efficacy of such approaches. Integrating fertility preservation into the overall BC treatment strategy can markedly improve women's quality of life by increasing their chances of regaining reproductive function after completing primary treatment.

В статье рассматриваются актуальные методы сохранения фертильности у женщин, проходящих лечение рака молочной железы (РМЖ). Подробно обсуждаются современные методы лечения РМЖ и их влияние на фертильность. Описаны ключевые стратегии, применяемые для предотвращения потери фертильности, включая криоконсервацию яйцеклеток, эмбрионов и ткани яичников, а также временное подавление функции яичников с помощью агонистов гонадотропин-рилизинг гормона. Анализируются факторы, затрудняющие доступ к этим методам, такие как недостаток информации, ограниченные ресурсы здравоохранения и необходимость немедленного начала противораковой терапии. Подчеркивается важность комплексной системы поддержки пациенток, включающей координацию действий онкологов, специалистов по репродуктивным технологиям и психологов. Особое внимание уделяется важности дальнейшего развития и усовершенствования существующих методов, направленных на снижение гонадотоксичности, а также продолжению исследований для выявления новых безопасных и эффективных стратегий. Указывается на значимость долгосрочного наблюдения за детьми, рожденными с использованием сохраненных гамет и тканей, для оценки безопасности и результативности применяемых методов. Интеграция методов сохранения фертильности в общую стратегию лечения РМЖ может существенно улучшить качество жизни женщин, повысив их шансы на восстановление репродуктивной функции после завершения основного курса лечения.

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The authors declare that there are no conflicts of interest present.