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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2025.567</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-2348</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group></article-categories><title-group><article-title>Lipodermatosclerosis as a potential complication of chronic venous insufficiency</article-title><trans-title-group xml:lang="ru"><trans-title>Липодерматосклероз как возможное осложнение хронической венозной недостаточности</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-2140-6797</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блбулян</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Blbulyan</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Армен Кимович Блбулян, д.м.н.</p><p>0002 Ереван, проспект Маштоца, д. 22</p></bio><bio xml:lang="en"><p>Armen K. Blbulyan, MD, Dr Sci Med. </p><p>22 Mashtots Avenue, Erevan 0002</p></bio><email xlink:type="simple">belbulyan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арустамян</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Arustamyan</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арустамян Карине Кареновна, д.м.н.</p><p>0002 Ереван, проспект Маштоца, д. 22</p></bio><bio xml:lang="en"><p>Karine K. Arustamyan, MD, Dr Sci Med.</p><p>22 Mashtots Avenue, Erevan 0002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манукян</surname><given-names>Л. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Manukyan</surname><given-names>L. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манукян Лусинэ Карленовна, к.м.н</p><p>0002 Ереван, проспект Маштоца, д. 22</p></bio><bio xml:lang="en"><p>Lusine K. Manukyan, MD, PhD</p><p>22 Mashtots Avenue, Erevan 0002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минасян</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Minasyan</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минасян Софья Арамовна</p><p>0002 Ереван, проспект Маштоца, д. 22</p></bio><bio xml:lang="en"><p>Sofya A. Minasyan, MD. </p><p>22 Mashtots Avenue, Erevan 0002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гомцян</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gomtsyan</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гомцян Гаянэ Араратовна, к.м.н. </p><p>0002 Ереван, проспект Маштоца, д. 22</p></bio><bio xml:lang="en"><p>Gayane A. Gomtsyan, MD, PhD.</p><p>22 Mashtots Avenue, Erevan 0002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский центр охраны здоровья матери и ребенка Министерства здравоохранения Республики Армения</institution><country>Армения</country></aff><aff xml:lang="en"><institution>Research Center of Maternal and Child Health Protection</institution><country>Armenia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>06</day><month>03</month><year>2025</year></pub-date><volume>19</volume><issue>1</issue><fpage>110</fpage><lpage>115</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Blbulyan A.K., Arustamyan K.K., Manukyan L.K., Minasyan S.A., Gomtsyan G.A., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Блбулян А.К., Арустамян К.К., Манукян Л.К., Минасян С.А., Гомцян Г.А.</copyright-holder><copyright-holder xml:lang="en">Blbulyan A.K., Arustamyan K.K., Manukyan L.K., Minasyan S.A., Gomtsyan G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/2348">https://www.gynecology.su/jour/article/view/2348</self-uri><abstract><p>Pregnancy and childbirth in women with varicose vein disease (VVD) are typically associated with a high risk of developing thrombotic, obstetric and fetal complications. Lipodermatosclerosis (LDS) is one of the less common complications related to chronic venous insufficiency (CVI). This article presents a clinical case where LDS developed during late-stage pregnancy (35–36 weeks) as a complication of pre-existing VVD, which is noteworthy due to the rarity of such condition that demonstrates relevant diagnostic challenges particularly during pregnancy. Enhancing the effectiveness of a multidisciplinary approach is essential for diagnosing rare VVD complications in pregnant women.</p></abstract><trans-abstract xml:lang="ru"><p>Беременность и роды у женщин с варикозной болезнью (ВБ) обычно сопряжены с высоким риском развития тромботических, акушерских и плодовых осложнений. Одним из редко встречаемых осложнений хронической венозной недостаточности (ХВН), является липодерматосклероз (ЛДС). В статье представлен клинический случай развития ЛДС у беременной на поздних сроках гестации (35–36 недель) как осложнение имеющейся ВБ. Данный клинический случай представляет интерес по причине редкой встречаемости заболевания и демонстрирует сложность диагностики данной патологии, особенно у беременных. Необходимо совершенствование и повышение эффективности мультидисциплинарного подхода в плане диагностики редко встречающихся осложнений ВБ у беременных.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>варикозная болезнь</kwd><kwd>ВБ</kwd><kwd>липодерматосклероз</kwd><kwd>ЛДС</kwd><kwd>хроническая венозная недостаточность</kwd><kwd>ХВН</kwd><kwd>синдром Мей–Тернера</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>varicose vein disease</kwd><kwd>VVD</kwd><kwd>lipodermatosclerosis</kwd><kwd>LDS</kwd><kwd>chronic venous insufficiency</kwd><kwd>CVI</kwd><kwd>May–Thurner syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хрыщанович В.Я., Роговой Н.А., Скобелева Н.Я., Красько О.В. Эффективность компрессионной и флеботропной терапии варикозной болезни у беременных. Амбулаторная хирургия. 2023;20(1):94–104. https://doi.org/10.21518/akh2022-007.</mixed-citation><mixed-citation xml:lang="en">Khryshchanovich V.Ya., Rogovoy N.A., Skobeleva N.Ya., Krasko O.V. Efficacy of compression and phlebotropic therapy varicose veins in pregnant women. [Effektivnost' kompressionnoj i flebotropnoj terapii varikoznoj bolezni u beremennyh]. Ambulatornaya khirurgiya. 2023;20(1):94–104. (In Russ.). https://doi.org/10.21518/akh2022-007.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шульман С. Тромбоз вен малого таза, ассоциированный с беременностью. Акушерство, Гинекология и Репродукция. 2021;15(5):627–32. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.261.</mixed-citation><mixed-citation xml:lang="en">Schulman S. Pregnancy-related pelvic vein thrombosis. Obstetrics, Gynecology and Reproduction. 2021;15(5):627–32. (In English). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.261.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Акиньшина С.В., Макацария А.Д., Бицадзе В.О., Андреева М.Д. Клиника, диагностика и профилактика венозных тромбоэмболических осложнений во время беременности. Акушерство, Гинекология и Репродукция. 2014;8(4):27–35.</mixed-citation><mixed-citation xml:lang="en">Akinshina S.V., Makatsariya A.D., Bitsadze V.O., Andreeva M.D. Clinical picture, diagnosis and prevention of venous thromboembolic complications during pregnancy. Obstetrics, Gynecology and Reproduction. 2014;8(4):27–35. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Щава С.Н. Липодерматосклероз в практике дерматовенеролога (клинический случай), Саратовский научно-медицинский журнал. Приложение: Дерматовенерология. 2022;18(4):740–2.</mixed-citation><mixed-citation xml:lang="en">Shchava S.N. Lipodermatosclerosis in the practice of a dermatovenerologist (clinical case). [Lipodermatoskleroz v praktike dermatovenerologa (klinicheskij sluchaj)]. Saratovskij nauchnomedicinskij zhurnal. Prilozhenie: Dermatovenerologiya. 2022;18(4):740–2. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Huriez C., Legache G., Desmons F. et al. Leg ulcers and trophic disorders of venous origin: data from the study of one thousand hospitalized patients with ulsers. Rev Prat. 1955;5(26):2703–21. (In French.).</mixed-citation><mixed-citation xml:lang="en">Huriez C., Legache G., Desmons F. et al. Leg ulcers and trophic disorders of venous origin: data from the study of one thousand hospitalized patients with ulsers. Rev Prat. 1955;5(26):2703–21. (In French.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega M.A., Asunsolo A., Alvarez-Rocha M.J. et al. Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. Histol Histopathol. 2018;33(6):567–76. https://doi.org/10.14670/HH-11-948.</mixed-citation><mixed-citation xml:lang="en">Ortega M.A., Asunsolo A., Alvarez-Rocha M.J. et al. Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. Histol Histopathol. 2018;33(6):567–76. https://doi.org/10.14670/HH-11-948.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Troiano N.H. Physiologic and hemodynamic changes during pregnancy. AACN Adv Crit Care. 2018;29(3):273–83. https://doi.org/10.4037/aacnacc2018911.</mixed-citation><mixed-citation xml:lang="en">Troiano N.H. Physiologic and hemodynamic changes during pregnancy. AACN Adv Crit Care. 2018;29(3):273–83. https://doi.org/10.4037/aacnacc2018911.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sies H. Oxidative stress: introductory remarks. In: Oxidative Stress. Ed. H. Sies. London: Academic Press, 1985. 1–8. https://doi.org/10.1016/b978-0-12-642760-8.50005-3.</mixed-citation><mixed-citation xml:lang="en">Sies H. Oxidative stress: introductory remarks. In: Oxidative Stress. Ed. H. Sies. London: Academic Press, 1985. 1–8. https://doi.org/10.1016/b978-0-12-642760-8.50005-3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega M.A., Romero B., Asunsolo A. et al. Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress. J Cell Mol Med. 2020;24(7):4157–70. https://doi.org/10.1111/jcmm.15077.</mixed-citation><mixed-citation xml:lang="en">Ortega M.A., Romero B., Asunsolo A. et al. Pregnancy-associated venous insufficiency course with placental and systemic oxidative stress. J Cell Mol Med. 2020;24(7):4157–70. https://doi.org/10.1111/jcmm.15077.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rodríguez-Mañas L., El-Assar M., Vallejo S. et al. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8(3):226–38. https://doi.org/10.1111/j.1474-9726.2009.00466.x.</mixed-citation><mixed-citation xml:lang="en">Rodríguez-Mañas L., El-Assar M., Vallejo S. et al. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8(3):226–38. https://doi.org/10.1111/j.1474-9726.2009.00466.x.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Biri A., Bozkurt N., Turp A. et al. Role of oxidative stress in intrauterine growth restriction. Gynecol Obstet Invest. 2007;64(4):187–92. https://doi.org/10.1159/000106488.</mixed-citation><mixed-citation xml:lang="en">Biri A., Bozkurt N., Turp A. et al. Role of oxidative stress in intrauterine growth restriction. Gynecol Obstet Invest. 2007;64(4):187–92. https://doi.org/10.1159/000106488.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yockey L.J., Iwasaki A. Interferons and proinflammatory cytokines in pregnancy and fetal development. Immunity. 2018;49(3):397–12. https://doi.org/10.1016/j.immuni.2018.07.017.</mixed-citation><mixed-citation xml:lang="en">Yockey L.J., Iwasaki A. Interferons and proinflammatory cytokines in pregnancy and fetal development. Immunity. 2018;49(3):397–12. https://doi.org/10.1016/j.immuni.2018.07.017.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Uciechowski P., Dempke W.C.M. Interleukin-6: a masterplayer in the cytokine network. Oncology. 2020;98(3):131–7. https://doi.org/10.1159/000505099.</mixed-citation><mixed-citation xml:lang="en">Uciechowski P., Dempke W.C.M. Interleukin-6: a masterplayer in the cytokine network. Oncology. 2020;98(3):131–7. https://doi.org/10.1159/000505099.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega M.A., Gomez-Lahoz A.M., Sanchez-Trujillo L. et al. Chronic venous disease during pregnancy causes a systematic increase in maternal and fetal proinflammatory markers. Int J Mol Sci. 2022;23(16):8976. https://doi.org/10.3390/ijms23168976.</mixed-citation><mixed-citation xml:lang="en">Ortega M.A., Gomez-Lahoz A.M., Sanchez-Trujillo L. et al. Chronic venous disease during pregnancy causes a systematic increase in maternal and fetal proinflammatory markers. Int J Mol Sci. 2022;23(16):8976. https://doi.org/10.3390/ijms23168976.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Li M., Wu Z.-M., Yang H., Huang S.J. NFκB and JNK/MAPK activation mediates the production of major macrophage- or dendritic cell-recruiting chemokine in human first trimester decidual cells in response to proinflammatory stimuli. J Clin Endocrinol Metab. 2011;96(8):2502–11. https://doi.org/10.1210/jc.2011-0055.</mixed-citation><mixed-citation xml:lang="en">Li M., Wu Z.-M., Yang H., Huang S.J. NFκB and JNK/MAPK activation mediates the production of major macrophage- or dendritic cell-recruiting chemokine in human first trimester decidual cells in response to proinflammatory stimuli. J Clin Endocrinol Metab. 2011;96(8):2502–11. https://doi.org/10.1210/jc.2011-0055.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Amin T., Cohen H., Wong M. et al. The prevalence of incidental uterine venous plexus thrombosis in women attending a gynecology clinic. J Thromb Haemost. 2020;18(10):2557–65. https://doi.org/10.1111/jth.14989.</mixed-citation><mixed-citation xml:lang="en">Amin T., Cohen H., Wong M. et al. The prevalence of incidental uterine venous plexus thrombosis in women attending a gynecology clinic. J Thromb Haemost. 2020;18(10):2557–65. https://doi.org/10.1111/jth.14989.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega M., Fraile-Martínez O., García-Montero C. et al. Understanding chronic venous disease: A critical overview of its pathophysiology and medical management. J Clin Med. 2021;10(15):3239. https://doi.org/10.3390/jcm10153239.</mixed-citation><mixed-citation xml:lang="en">Ortega M., Fraile-Martínez O., García-Montero C. et al. Understanding chronic venous disease: A critical overview of its pathophysiology and medical management. J Clin Med. 2021;10(15):3239. https://doi.org/10.3390/jcm10153239.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega M.A., Romero B., Asunsolo A. et al. Patients with incompetent valves in chronic venous insufficiency show increased systematic lipid peroxidation and cellular oxidative stress markers. Oxid Med Cell Longev. 2019;2019:5164576. https://doi.org/10.1155/2019/5164576.</mixed-citation><mixed-citation xml:lang="en">Ortega M.A., Romero B., Asunsolo A. et al. Patients with incompetent valves in chronic venous insufficiency show increased systematic lipid peroxidation and cellular oxidative stress markers. Oxid Med Cell Longev. 2019;2019:5164576. https://doi.org/10.1155/2019/5164576.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mei J.Y., Deshmukh U., Negi M. et al. May-Thurner syndrome in pregnancy: a multi-institutional case series and review of the literature. Am J Obstet Gynecol MFM. 2020;2(4):100240. https://doi.org/10.1016/j.ajogmf.2020.100240.</mixed-citation><mixed-citation xml:lang="en">Mei J.Y., Deshmukh U., Negi M. et al. May-Thurner syndrome in pregnancy: a multi-institutional case series and review of the literature. Am J Obstet Gynecol MFM. 2020;2(4):100240. https://doi.org/10.1016/j.ajogmf.2020.100240.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lohr J.M., Bush R.L. Venous disease in women: epidemiology, manifestations, and treatment. J Vasc Surg. 2013;57(4 Suppl):37S–45S. https://doi.org/10.1016/j.jvs.2012.10.121.</mixed-citation><mixed-citation xml:lang="en">Lohr J.M., Bush R.L. Venous disease in women: epidemiology, manifestations, and treatment. J Vasc Surg. 2013;57(4 Suppl):37S–45S. https://doi.org/10.1016/j.jvs.2012.10.121.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Vlajinac H.D., Radak D.J., Marinkovic J.M., Maksimovic M.Z. Risk factors for chronic venous disease. Phlebology. 2012;27(8):416–22. https://doi.org/10.1258/phleb.2011.011091.</mixed-citation><mixed-citation xml:lang="en">Vlajinac H.D., Radak D.J., Marinkovic J.M., Maksimovic M.Z. Risk factors for chronic venous disease. Phlebology. 2012;27(8):416–22. https://doi.org/10.1258/phleb.2011.011091.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
