akusherstvoObstetrics, Gynecology and ReproductionАкушерство, Гинекология и Репродукция2313-73472500-3194IRBIS LLC10.17749/2313-7347/ob.gyn.rep.2024.543akusherstvo-2196Research ArticleCLINICAL CASESКЛИНИЧЕСКИЕ СЛУЧАИA rare case of early-onset neonatal sepsis caused by Proteus mirabilis in the first infant of tetrachorionic triamniotic tripletsРедкий случай раннего неонатального сепсиса, вызванного Proteus mirabilis, у первого ребенка из тетрахориальной триамниотической тройниhttps://orcid.org/0000-0002-1024-0230КарповаА. Л.KarpovaA. L.

Карпова Анна Львовна, к.м.н.

123423 Москва, ул. Саляма Адиля, д. 2/44;123995 Москва, ул. Баррикадная, 2/1, корп. 1; 150000 Ярославль, ул. Революционная, д. 5

Anna L. Karpova, MD, PhD. 

2/44 Salyama Adilya Str., Moscow 123423; 2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;5 Revolutsionnaya Str., Yaroslavl 150000

https://orcid.org/0000-0002-7040-9683МостовойА. В.MostovoiA. V.

Мостовой Алексей Валерьевич, к.м.н.

Scopus Author ID: 57201723894.

Wos ResearcherID: AAR-7908-2021.

123423 Москва, ул. Саляма Адиля, д. 2/44;123995 Москва, ул. Баррикадная, 2/1, корп. 1; 150000 Ярославль, ул. Революционная, д. 5

Aleksei V. Mostovoi, MD, PhD.

Scopus Author ID: 57201723894.

Wos ResearcherID: AAR-7908-2021.

2/44 Salyama Adilya Str., Moscow 123423; 2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;5 Revolutsionnaya Str., Yaroslavl 150000

valmost@mail.ruhttps://orcid.org/0000-0001-9269-9434АвдейО. В.AvdeiO. V.

Ольга Владимировна Авдей

123423 Москва, ул. Саляма Адиля, д. 2/44

Olga V. Avdei, MD. 

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0001-9270-6534ДудкинаЕ. А.DudkinaE. A.

Евгения Александровна Дудкина

123423 Москва, ул. Саляма Адиля, д. 2/44

Eugenia A. Dudkina, MD. 

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0009-0001-2776-9069ЗагдайС. П.ZagdaiS. P.

Светлана Павловна Загдай

123423 Москва, ул. Саляма Адиля, д. 2/44

Svetlana P. Zagdai, MD.

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0009-0001-0210-4669АникееваЛ. А.AnikeevaL. A.

Любовь Алексеевна Аникеева

123423 Москва, ул. Саляма Адиля, д. 2/44

Lyubov’ A. Anikeeva, MD.

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0009-0002-9782-0795ХотееваА. П.KhoteevaA. P.

Анна Петровна Хотеева

123423 Москва, ул. Саляма Адиля, д. 2/44

Anna P. Khoteeva, MD. 

2/44 Salyama Adilya Str., Moscow 123423

https://orcid.org/0000-0001-7210-1116ОрловаО. Е.OrlovaO. E.

Ольга Евгеньевна Орлова, к.б.н.

Scopus Author ID: 57200200546.

123423 Москва, ул. Саляма Адиля, д. 2/44; 119234 Москва, Ленинские горы, д. 1

 

Olga E. Orlova, MD, PhD in Biology.

Scopus Author ID: 57200200546. 

2/44 Salyama Adilya Str., Moscow 123423;1 Leninskie Gory, Moscow 119234

https://orcid.org/0000-0001-6728-726XКарповН. Ю.KarpovN. Yu.

Карпов Николай Юрьевич

152303 Тутаев, ул. Комсомольская, д. 104

Nikolai Yu. Karpov, MD. 

104 Komsomolskaya Str., Tutaev, Yaroslavl Region 152303

ГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации; ФГБОУ ВО «Ярославский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation; Yaroslavl State Medical University, Health Ministry of Russian FederationRussian FederationГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»РоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentRussian FederationГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»; ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare Department; Lomonosov Moscow State UniversityRussian FederationГБУЗ Ярославской области «Тутаевская центральная районная больница»РоссияTutaev Central District HospitalRussian Federation202407102024185743753Copyright © Karpova A.L., Mostovoi A.V., Avdei O.V., Dudkina E.A., Zagdai S.P., Anikeeva L.A., Khoteeva A.P., Orlova O.E., Karpov N.Y., 20242024Карпова А.Л., Мостовой А.В., Авдей О.В., Дудкина Е.А., Загдай С.П., Аникеева Л.А., Хотеева А.П., Орлова О.Е., Карпов Н.Ю.Karpova A.L., Mostovoi A.V., Avdei O.V., Dudkina E.A., Zagdai S.P., Anikeeva L.A., Khoteeva A.P., Orlova O.E., Karpov N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.gynecology.su/jour/article/view/2196

Early-onset neonatal sepsis (EОNS) is one of the most severe diseases of the neonatal period and is often coupled to extremely unfavorable outcomes. In many ways, the severity of the condition and the results of newborn nursing depend on the etiology of the bacterial process. The major EОNS pathogens are traditionally considered to be Streptococcus group B and E. coli, much less common are other Gram-negative bacteria including casuistic cases caused by caused by Proteus mirabilis (P. mirabilis). The article provides a review on the P. mirabilis role in developing neonatal sepsis with pathogen-specific disease course and outcomes. In addition, we describe a clinical case of P. mirabilis-caused EОNS not only primarily characterized by the rarity of its causative agent, but also that it proceeded with a more favorable brain damage in contrast to similar cases described worldwide and because the neonatal EОNS developed in one of triplets, with two other babies being asymptomatic despite that P. mirabilis was also detected.

Ранний неонатальный сепсис (РНС) является одним из наиболее тяжелых заболеваний периода новорожденности и нередко сопряжен с крайне неблагоприятными исходами. Во многом тяжесть состояния и результаты выхаживания новорожденных детей зависят от этиологии генерализованного бактериального процесса. Основными возбудителями РНС традиционно считаются стрептококк группы В и кишечная палочка, значительно реже встречаются другие грамотрицательные бактерии, среди которых как казуистические описываются случаи развития РНС, вызванные Proteus mirabilis (P. mirabilis). Представляем обзор современной литературы, посвященный роли P. mirabilis в развитии неонатального сепсиса с характерными для данного возбудителя особенностями течения заболевания и исходами, а также клинический случай РНС, вызванного P. mirabilis. Данное клиническое наблюдение эксклюзивно не только редкостью возбудителя заболевания, но и тем, что протекало оно с точки зрения повреждения головного мозга более благоприятно, в отличие от описанных в мировой литературе подобных случаев, а также тем, что новорожденный ребенок с РНС – первый из тройни, а у двух других детей РНС не развился, несмотря на то, что у них тоже был выявлен P. mirabilis.

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The authors declare that there are no conflicts of interest present.