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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">akusherstvo</journal-id><journal-title-group><journal-title xml:lang="en">Obstetrics, Gynecology and Reproduction</journal-title><trans-title-group xml:lang="ru"><trans-title>Акушерство, Гинекология и Репродукция</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7347</issn><issn pub-type="epub">2500-3194</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2313-7347/ob.gyn.rep.2024.544</article-id><article-id custom-type="elpub" pub-id-type="custom">akusherstvo-2168</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM HISTORY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИЗ ИСТОРИИ</subject></subj-group></article-categories><title-group><article-title>100 years of Moschcowitz disease and thrombotic microangiopathy research: a look into the past and prospects</article-title><trans-title-group xml:lang="ru"><trans-title>100 лет исследования болезни Мошковица и тромботической микроангиопатии: взгляд в прошлое и перспективы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6018-4667</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шатилина</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shatilina</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шатилина Анастасия Юрьевна.</p><p>119991 Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Anastasia Yu. Shatilina.</p><p>8 bldg. 2, Trubetskaya Str., Moscow 119991</p></bio><email xlink:type="simple">shatilina1110@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-5331-7894</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаджиева</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Hajiyeva</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаджиева Айгюн Бахтияр кызы.</p><p>AZ1143 Баку, проспект Гусейна Джавида, д. 33</p></bio><bio xml:lang="en"><p>Aygun B. Hajiyeva.</p><p>33 Huseyn Javid Avenue, Baku, AZ1143</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1733-7502</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Велиханова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Valikhanova</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Велиханова Лала Мехти.</p><p>AZ1143 Баку, проспект Гусейна Джавида, д. 33</p></bio><bio xml:lang="en"><p>Lala M. Valikhanova.</p><p>33 Huseyn Javid Avenue, Baku, AZ1143</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8197-4998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещеряков</surname><given-names>А. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshcheryakov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мещеряков Арсений Александрович.</p><p>127006 Москва, Долгоруковская ул., д. 4</p></bio><bio xml:lang="en"><p>Arseniy A. Meshcheryakov.</p><p>4 Dolgorukovskaya Str., Moscow 127006</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0764-4477</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гашимова</surname><given-names>Н. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gashimova</surname><given-names>N. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гашимова Нилуфар Рамиль кызы.</p><p>119991 Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Nilufar R. Gashimova - MD.</p><p>8 bldg. 2, Trubetskaya Str., Moscow 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7756-8935</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьева</surname><given-names>К. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoreva</surname><given-names>K. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Григорьева Кристина Николаевна.</p><p>119991 Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Kristina N. Grigoreva - MD.</p><p>8 bldg. 2, Trubetskaya Str., Moscow 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4509-9281</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьев Александр Викторович - к.м.н.</p><p>119991 Москва, ул. Трубецкая, д. 8, стр. 2</p><p>Scopus Author ID 57191966265; Wos ResearcherID F-8804-2017</p></bio><bio xml:lang="en"><p>Alexander V. Vorobev - MD, PhD.</p><p>8 bldg. 2, Trubetskaya Str., Moscow 119991</p><p>Scopus Author ID 57191966265; Wos ResearcherID F-8804-2017</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Бакинский филиал ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>Baku Branch of Sechenov University</institution><country>Azerbaijan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine, Health Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>12</day><month>09</month><year>2024</year></pub-date><volume>18</volume><issue>4</issue><fpage>603</fpage><lpage>611</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shatilina A.Y., Hajiyeva A.B., Valikhanova L.M., Meshcheryakov A.A., Gashimova N.R., Grigoreva K.N., Vorobev A.V., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Шатилина А.Ю., Гаджиева А.Б., Велиханова Л.М., Мещеряков А.A., Гашимова Н.Р., Григорьева К.Н., Воробьев А.В.</copyright-holder><copyright-holder xml:lang="en">Shatilina A.Y., Hajiyeva A.B., Valikhanova L.M., Meshcheryakov A.A., Gashimova N.R., Grigoreva K.N., Vorobev A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.gynecology.su/jour/article/view/2168">https://www.gynecology.su/jour/article/view/2168</self-uri><abstract><p>In this article we review the history of the thrombotic microangiopathy (TMA) study over the past 100 years. Important events and discoveries made by scientists across the globe are described, which profoundly contributed to understanding TMA etiology, pathogenesis and treatment. The prospects for current TMA investigation especially in obstetric practice are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматривается история изучения тромботической микроангиопатии (ТМА) за последние 100 лет. Описаны важные события и открытия ученых со всего мира, внесших большой вклад в понимание этиологии, патогенеза и лечения ТМА. Рассматриваются перспективы изучения ТМА в настоящее время, особенно в акушерской практике.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромботическая микроангиопатия</kwd><kwd>ТМА</kwd><kwd>тромботическая тромбоцитопеническая пурпура</kwd><kwd>гемолитико-уремический синдром</kwd><kwd>сверхбольшие мультимеры фактора фон Виллебранда</kwd><kwd>ADAMTS-13</kwd><kwd>Эли Мошковиц</kwd><kwd>Джон Ультманн</kwd><kwd>Эрик Адольф фон Виллебранд</kwd><kwd>Джефферсон Д. Апшоу</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombotic microangiopathy</kwd><kwd>ТМА</kwd><kwd>thrombotic thrombocytopenic purpura</kwd><kwd>hemolytic uremic syndrome</kwd><kwd>ultra-large multimers of von Willebrand factor</kwd><kwd>ADAMTS-13</kwd><kwd>Eli Moschcowitz</kwd><kwd>John Ultmann</kwd><kwd>Erik Adolf von Willebrand</kwd><kwd>Jefferson D. 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