References

akusherstvo

Obstetrics, Gynecology and Reproduction

Акушерство, Гинекология и Репродукция

2313-73472500-3194

IRBIS LLC

10.17749/2313-7347/ob.gyn.rep.2024.542

akusherstvo-2167

Research Article

EDITORIAL

РЕДАКЦИОННАЯ СТАТЬЯ

The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients

Концепция тромбовоспаления как основы тромботических осложнений, прогрессии опухоли и метастазирования у онкогинекологических больных

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8 bldg. 2, Trubetskaya Str., Moscow 119991

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8 bldg. 2, Trubetskaya Str., Moscow 119991

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8 bldg. 2, Trubetskaya Str., Moscow 119991

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vikabits@mail.ru

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Солопова

А. Г.

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A. G.

Солопова Антонина Григорьевна - д.м.н., проф.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Scopus Author ID 6505479504; WoS ResearcherID Q-1385-2015

Antonina G. Solopova - MD, Dr Sci Med, Prof.

8 bldg. 2, Trubetskaya Str., Moscow 119991

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Д. Х.

Khizroeva

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Jamilya Kh. Khizroeva - MD, Dr Sci Med, Prof.

8 bldg. 2, Trubetskaya Str., Moscow 119991

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Ашрафян

Л. А.

Ashrafyan

L. A.

Ашрафян Лев Андреевич - д.м.н., проф., академик РАН.

117997 Москва, ул. академика Опарина, д. 4

Scopus Author ID 57194173388

Lev A. Ashrafyan - MD, Dr Sci Med, Prof., Academician of RAS.

4 Academika Oparina Str., Moscow 117997

Scopus Author ID 57194173388

https://orcid.org/0000-0003-2976-7128

Серов

В. Н.

Serov

V. N.

Серов Владимир Николаевич - д.м.н., проф., академик РАН.

117997 Москва, ул. академика Опарина, д. 4

Vladimir N. Serov - MD, Dr Sci Med, Prof., Academician of RAS.

4 Academika Oparina Str., Moscow 117997

https://orcid.org/0000-0003-4761-5793

Войновский

А. Е.

Voynovskiy

A. Е.

Войновский Александр Евгеньевич - д.м.н., проф.

123423 Москва, ул. Саляма Адиля, д. 2/44

WoS ResearcherlD S-6385-2016

Alexander Е. Voynovskiy - MD, Dr Sci Med, Prof.

2/44 Salyama Adilya Str., Moscow 123423

WoS ResearcherlD S-6385-2016

https://orcid.org/0000-0002-3337-4995

Унгиадзе

Д. Ю.

Ungiadze

J. Yu.

Унгиадзе Джумбер Юрьевич - д.м.н., проф.

6010 Автономная Республика Аджария, Батуми, ул. Ниношвили, д. 35

Jumber Yu. Ungiadze - MD, Dr Sci Med, Prof.

35 Ninoshvili Str., Batumi, Autonomous Republic of Adjara 6010

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А. В.

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A. V.

Лазарчук Арина Владимировна.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Arina V. Lazarchuk.

8 bldg. 2, Trubetskaya Str., Moscow 119991

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М. В.

Tretyakova

M. V.

Третьякова Мария Владимировна - к.м.н.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Maria V. Tretyakova - MD, PhD.

8 bldg. 2, Trubetskaya Str., Moscow 119991

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Макацария

Н. А.

Makatsariya

N. A.

Макацария Наталия Александровна - к.м.н.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

WoS ResearcherID F-8406-2017

Nataliya A. Makatsariya - MD, PhD.

8 bldg. 2, Trubetskaya Str., Moscow 119991

WoS ResearcherID F-8406-2017

https://orcid.org/0000-0003-2011-1237

Сальникова

П. В.

Salnikova

P. V.

Сальникова Полина Владимировна.

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Polina V. Salnikova.

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Н. Р.

Gashimova

N. R.

Гашимова Нилуфар Рамиль кызы.

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Nilufar R. Gashimova - MD.

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Kristina N. Grigoreva - MD.

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Закашанский

К. Л.

Zakashansky

K. L.

Закашанский Константин Львович.

10029-6574 Нью-Йорк, ящик 1173, Пятая авеню, 1176

Konstantin L. Zakashansky - MD.

1176 Fifth Avenue, Box 1173, New York 10029-6574

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Элалами

И.

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119991 Москва, ул. Трубецкая, д. 8, стр. 2; Франция, 75006 Париж, Улица медицинского факультета, д. 12; Франция, 75020 Париж, Китайская улица, д. 4

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8 bldg. 2, Trubetskaya Str., Moscow 119991; 12 Rue de Г Ecole de Medecine, Paris 75006, France; 4 Rue de la Chine, Paris 75020, France

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Гри

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Gris

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Гри Жан-Кристоф - д.м.н., проф.

119991 Москва, ул. Трубецкая, д. 8, стр. 2; Франция, 34090 Монпелье, ул. Огюста Бруссоне, д. 163

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Jean-Christophe Gris - MD, Dr Sci Med, Prof.

8 bldg. 2, Trubetskaya Str., Moscow 119991; 163 Rue Auguste Broussonnet, Montpellier 34090, France

Scopus Author ID 7005114260; WoS ResearcherID AAA-2923-2019

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian Federation

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской ФедерацииРоссияKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationRussian Federation

ГБУЗ «Городская клиническая больница № 67 имени Л.А. Ворохобова Департамента здравоохранения города Москвы»РоссияVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentRussian Federation

Батумский государственный университет имени Шота РуставелиГрузияShota Rustaveli Batumi State UniversityGeorgia

Медицинская школа Икан в Маунт-СинайСоединённые Штаты АмерикиIcahn School of Medicine at Mount SinaiUnited States

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Медицинский Университет Сорбонны; Госпиталь ТенонРоссияSechenov University; Medicine Sorbonne University; Hospital TenonRussian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет); Университет МонпельеРоссияSechenov University; University of MontpellierRussian Federation

2024

12092024

184450463

Copyright © Makatsariya A.D., Slukhanchuk E.V., Bitsadze V.O., Solopova A.G., Khizroeva J.K., Ashrafyan L.A., Serov V.N., Voynovskiy A.Е., Ungiadze J.Y., Lazarchuk A.V., Tretyakova M.V., Makatsariya N.A., Salnikova P.V., Gashimova N.R., Grigoreva K.N., Zakashansky K.L., Elalamy I., Gris J., 2024

2024

Макацария А.Д., Слуханчук Е.В., Бицадзе В.О., Солопова А.Г., Хизроева Д.Х., Ашрафян Л.А., Серов В.Н., Войновский А.Е., Унгиадзе Д.Ю., Лазарчук А.В., Третьякова М.В., Макацария Н.А., Сальникова П.В., Гашимова Н.Р., Григорьева К.Н., Закашанский К.Л., Элалами И., Гри Ж.

Makatsariya A.D., Slukhanchuk E.V., Bitsadze V.O., Solopova A.G., Khizroeva J.K., Ashrafyan L.A., Serov V.N., Voynovskiy A.Е., Ungiadze J.Y., Lazarchuk A.V., Tretyakova M.V., Makatsariya N.A., Salnikova P.V., Gashimova N.R., Grigoreva K.N., Zakashansky K.L., Elalamy I., Gris J.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.gynecology.su/jour/article/view/2167

The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During carcinogenesis, tumor cells express proinflammatory cytokines, proangiogenic and procoagulant factors, and also stimulate other cells to express various components promoting emerging thromboinflammation. The discovery of neutrophil extracellular traps (NETs) provides an opportunity to take a new look at biology and a role neutrophils may play in thromboinflammation and tumorigenesis. The close interplay between tumor cells, tumor-associated neutrophils and NETs as well as other players in the tumor microenvironment underlies activation of thromboinflammation in cancer patients not only resulting in thrombus formation, but also promoting tumor growth and dissemination.

Результаты исследований последних лет показывают, что в патогенез тромбоза при раке, а также в прогрессию опухоли, метастазирование и формирование химиорезистентности большой вклад вносят биология опухоли, активация свертывания и воспаления. Рак является независимым предиктором тромбоза. Опухолевые клетки в процессе канцерогенеза экспрессируют провоспалительные цитокины, проангиогенные и прокоагулянтные факторы, а также стимулируют другие клетки к экспрессии различных компонентов, способствуя развитию тромбовоспаления. Открытие внеклеточных ловушек нейтрофилов (англ. neutrophil extracellular traps, NETs) дает возможность по-новому взглянуть на биологию нейтрофилов и их участие в тромбовоспалении и опухолевом процессе. Тесное взаимодействие между опухолевыми клетками, опухоль-ассоциированными нейтрофилами и NETs с участием других игроков микроокружения опухоли лежит в основе активации тромбовоспаления у онкологических пациентов, что не только приводит к тромбообразованию, но и способствует росту и диссеминации опухоли.

тромбовоспалениенетозвнеклеточные ловушки нейтрофиловNETsнейтрофилыхимиорезистентностьтромбоз

thromboinflammationNETosisneutrophil extracellular trapsNETsneutrophilschemoresistancethrombosis

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The authors declare that there are no conflicts of interest present.